Our research advances interdisciplinary innovation in biomedical physics, integrating concepts from physics, materials science, engineering, and biomedicine. We focus on next-generation human–machine interfaces, regenerative medicine platforms, and functional materials, unified by a physics-driven design philosophy. Our mission is to merge advanced manufacturing with biomedical innovation to create devices and systems that seamlessly interface with the human body. To achieve this, we apply core principles of mechanics, electromagnetism, materials physics, and device behavior to address challenges that conventional bioengineering cannot fully resolve. We employ technologies such as extrusion-based 3D printing, origami-inspired self-folding, nanomaterials engineering, and soft magneto-electromechanical systems to build synthetic platforms that reproduce essential features of biological hierarchy—from cellular architecture to tissue-level organization. These engineered environments allow us to probe, direct, and manipulate biological processes with high precision. Through this physics-centered approach, we uncover new design rules and mechanistic insights that enable advances in smart biomedical devices and adaptive, bio-integrated systems. Collectively, our work expands the frontiers of engineered materials, living technologies, and human–machine interfacing.