Founding partners Domingo Roxas and Antonio de Ayala establish Casa Roxas, investing the bulk of its assets in a distillery, which is considered the country's first industry.

El Banco Espanol Filipino de Isabel II, precursor of the Bank of the Philippine Islands, is the first bank in the Philippines.

Tramcars, the country's first public mass transportation system, is introduced and operated by Jacobo Zobel y Zangroniz.

Ayala pioneers in insurance, first by investing in Insular Life then by establishing its own insurance companies.

Joseph McMicking creates the Ayala Master Plan, the blueprint for today's premier Makatı business, commercial and residential district and the inspiration for many integrated communities that came after it. 

Ayala invests in Globe-Mackay Cable and Radio Corporation, the company's first foray into telecommunications Ayala partners with Mitsubishi Corporation of Japan to explore new growth sectors.

Ayala becomes a publicly listed company. 

Ayala ventures into the electronics manufacturing services industry through Integrated Micro-Electronics Inc.

Ayala Land is spun off to grow the real estate business. 

With its partners, Ayala invests in automotive dealerships, beginning with Honda passenger vehicles, followed by Isuzu in 1995. Filipinas Foundation, established by Joseph and Mercedes Zobel McMicking in 1961, is renamed Ayala Foundation, reflecting the Ayala group's commitment to corporate social responsibility. 

AC Energy invests in power generation.

AC Infra, in partnership with the national government, begins to develop transport and highway infrastructure systems AC Education is formed to provide quality, affordable private education.

AC Health is established and begins with an investment in Generika pharmacies and FamilyDOC primary care clinics.

Ayala's automotive and manufacturing investments are consolidated under AC industrials AC Energy surpasses its target of 1,000 megawatts of attributable capacity 

Ayala makes key investments in fintech and e-commerce with tech start-ups like MedGrocer, Mynt and Zalora PH 

AC Industrials enters the solar energy business through the acquisition of a controlling stake in Merlin Solar Technologies It is also appointed by SAIC MAXUS Automotive as the official distributor of Maxus vehicles in the Philippines AC Industrials signs a distributorship agreement with Kia Motors Corporation to distribute the Kia brand in the Philippines 

AC Infrastructure and partner Zalora affiliate Brillant launch Entrego a technology-driven end-to-end logistics and solutions provider 

AC Health invests in pharmaceutical distributor IE Medica and its affiliate Ayala signs a definitive agreement to acquire a 20 percent stake in Myanmar-based Yoma Group for a total consideration of US$237.5 million for the investment. AC Health acquires Healthway Philippines, one of the leading clinic networks in the country.

AC Education acquires a ~96 percent stake in National Teachers College. The Ayala and Yuchengco groups sign definitive agreements for the merger of AC Education and iPeople, resulting in seven educational institutions with a combined student population of ~60,000.

The Ayala group completes the conversion of portions of the World Trade Center into a temporary healthcare facility for COVID 19 patients.

MI introduces the UK-developed UCL Ventura Flow Generator, a non-invasive ventilation system developed to aid COVID-19 patients with breathing difficulties.

AREIT, the country's first REIT, makes its successful IPO in the Philippine Stock Exchange.

Signs an Investment Agreement to acquire a 60%-stake in the AIR21 Group.

First shipment in Southeast Asia of Molnupiravir, an oral anti-viral treatment for mild COVID-19, arrives through MedEthix, AC Health's pharmaceutical importer and distributor.

Ayala commits to achieve net-zero greenhouse gas emissions by 2050.

Ayala Land, Inc. Marks its 30th anniversary as a listed company at the Philippine Stock Exchange.

Ayala Announces leadership transition, with Jaime Augusto Zobel de Ayala to focus on his role as Chairman and Fernando Zobel de Ayala to become President and CEO.

Completes the acquisition of a majority stake in the QualiMed Health Network.

AC Health/Globe Announced the merger of Ayala's healthtech platforms KonsultaMD, HealthNow and AIDE, forming the consolidated KonsultaMD superapp.

AC Health Entered into a partnership with Siemens Healthineers. a leading provider in healthcare systems, for the Healthway Cancer Care Hospital.

BPI Announced a merger with Robinsons Bank Corporation, with BPI as the surviving entity.

Ayala Land/IMI Announced the rollout of more than 20 electric vehicle charging hubs in seven key cities across Luzon.

AC Industrials Announced the 2023 rollout of Kia EV6, the group's first electric vehicle.

Ayala Appointed Cezar P. Consing as Ayala's CEO Mr Consing succeeds Fernando Zobel de Ayala who became Special Advisor to the Board.