J Lee, A Saparbayeva, J Kim, D Kwak, H Kim, M Ullah, M.L. Hakim, M Kim, E.H. Lee, I.-S. Yoon, M.-S. Kim, Y. Jung, J.-W. Yoo, Leukocyte esterase-activated nanoconjugates enables precise local therapy of ulcerative colitis via inflamed tissue-selective drug delivery, ACS Applied Materials & Interfaces, 17 (2025), 53168–53179 [link]
J. Lee, D. Kwak, H. Kim, M. Ullah, J. Kim, M. Naeem, S. Hwang, E. Im, I.-S. Yoon, Y. Jung, J.-W. Yoo, Elucidating a tumor-selective nanoparticle delivery mechanism at the colorectal lumen–tumor interface for precise local cancer therapy, Small, 21 (2025) 2409994. [link]
J. Lee, J. Kim, D. Kwak, H. Kim, M. Ullah, M.C. Kim, K. Hyun, E.H. Lee, H. Yun, Y. Jung, On-site sol-gel-sol transition of alginate enables reversible shielding/deshielding of tumor cell-activated nanoconjugates for precise local colorectal cancer therapy, Chemical Engineering Journal, 505 (2025) 158935. [link]
J. Lee, H. Jung, J.-W. Yoo, Recent advances in stimuli-responsive hydrogels for the treatment of infected cutaneous wounds, Yakhak Hoeji, 68 (2024) 303-310. [link]
M. Ullah, J. Lee, N. Hasan, M.L. Hakim, D. Kwak, H. Kim, E. Lee, J. Ahn, B. Mun, E.H. Lee, Clindamycin-loaded polyhydroxyalkanoate nanoparticles for the treatment of methicillin-resistant Staphylococcus aureus-infected wounds, Pharmaceutics, 16 (2024) 1315. [link]
H. Kim, J. Lee, D. Kwak, J. Kim, M. Kwon, K.S. Kim, J.-W. Yoo, Nitric oxide-releasing albumin/chondroitin sulfate bioadhesive dressing for the treatment of MRSA-infected wounds, Journal of Pharmaceutical Investigation, 54 (2024) 845-855. [link]
D. Kwak*, J. Lee*, J. Kim, H. Kim, J.-Y. Lee, D.-D. Kim, J.-W. Yoo, Nitric oxide-releasing albumin nanoclusters facilitate healing of methicillin-resistant Staphylococcus aureus-infected cutaneous wounds, Journal of Pharmaceutical Investigation, 54 (2024) 51-60. [link]
A. Saparbayeva*, J. Lee*, S.P. Hlaing, J. Kim, D. Kwak, H. Kim, E.H. Lee, S. Hwang, M.-S. Kim, H.R. Moon, Ionically bridged dexamethasone sodium phosphate–zinc–PLGA nanocomplex in alginate microgel for the local treatment of ulcerative colitis, Archives of Pharmacal Research, (2023) 1-13. [link]
S. Jeong, Y. Kim, S. Park, D. Lee, J. Lee, S.P. Hlaing, J.-W. Yoo, S.H. Rhee, E. Im, Lactobacillus plantarum metabolites elicit anticancer effects by inhibiting autophagy-related responses, Molecules, 28 (2023) 1890. [link]
J. Lee, J. Bae, D. Kwak, H. Kim, J. Kim, S.P. Hlaing, A. Saparbayeva, E.H. Lee, I.-S. Yoon, M.-S. Kim, 5-Fluorouracil crystal-incorporated, pH-responsive, and release-modulating PLGA/Eudragit FS hybrid microparticles for local colorectal cancer-targeted chemotherapy, International Journal of Pharmaceutics, (2022) 122443. [link]
J. Lee, A. Saparbayeva, S.P. Hlaing, D. Kwak, H. Kim, J. Kim, E.H. Lee, J.-W. Yoo, Cupriavidus necator-produced polyhydroxybutyrate/Eudragit FS hybrid nanoparticles mitigates ulcerative colitis via colon-targeted delivery of cyclosporine A, Pharmaceutics, 14 (2022) 2811. [link]
J. Cao, S.P. Hlaing, J. Lee, J. Kim, E.H. Lee, S.H. Kang, S.W. Hong, I.-S. Yoon, H. Yun, Y. Jung, Bacteria-adhesive nitric oxide-releasing graphene oxide nanoparticles for MRPA-infected wound healing therapy, ACS Applied Materials & Interfaces, 14 (2022) 50507-50519. [link]
C. Kang, S. Jeong, J. Kim, S. Ju, E. Im, G. Heo, S. Park, J.W. Yoo, J. Lee, I.S. Yoon, N‐Acetylserotonin is an oxidation‐responsive activator of Nrf2 ameliorating colitis in rats, Journal of Pineal Research, 74 (2023) e12835. [link]
J. Lee, M.A. Oshi, D. Kwak, H. Kim, J. Kim, S.P. Hlaing, A. Saparbayeva, S. Hwang, Y. Jung, J.-W. Yoo, On-demand reconstitutable hyaluronic acid-doped azathioprine microcrystals effectively ameliorate ulcerative colitis via selective accumulation in inflamed tissues, Biomaterials Science, 10 (2022) 6500-6509. [link]
S.P. Hlaing, J. Cao, J. Lee, J. Kim, A. Saparbayeva, D. Kwak, H. Kim, S. Hwang, H. Yun, H.R. Moon, Hyaluronic acid-conjugated PLGA nanoparticles alleviate ulcerative colitis via CD44-mediated dual targeting to inflamed colitis tissue and macrophages, Pharmaceutics, 14 (2022) 2118. [link]
N. Hasan, J. Lee, H.-J. Ahn, W.R. Hwang, M.A. Bahar, H. Habibie, M.N. Amir, S. Lallo, H.-J. Son, J.-W. Yoo, Nitric oxide-releasing bacterial cellulose/chitosan crosslinked hydrogels for the treatment of polymicrobial wound infections, Pharmaceutics, 14 (2021) 22. [link]
J. Kim, S.P. Hlaing, J. Lee, A. Saparbayeva, S. Kim, D.S. Hwang, E.H. Lee, I.-S. Yoon, H. Yun, M.-S. Kim, Exfoliated bentonite/alginate nanocomposite hydrogel enhances intestinal delivery of probiotics by resistance to gastric pH and on-demand disintegration, Carbohydrate Polymers, 272 (2021) 118462. [link]
W.-B. Seung, S.H. Cha, H.J. Kim, S.H. Choi, J. Lee, D. Kwak, H. Kim, J.-W. Yoo, Y.-W. Kim, S.K. Kim, Triolein emulsion enhances temozolomide brain delivery: an experimental study in rats, Drug Delivery, 28 (2021) 2373-2382. [link]
N. Hasan, J. Lee, D. Kwak, H. Kim, A. Saparbayeva, H.-J. Ahn, I.-S. Yoon, M.-S. Kim, Y. Jung, J.-W. Yoo, Diethylenetriamine/NONOate-doped alginate hydrogel with sustained nitric oxide release and minimal toxicity to accelerate healing of MRSA-infected wounds, Carbohydrate Polymers, 270 (2021) 118387. [link]
M.A. Oshi*, J. Lee*, J. Kim, N. Hasan, E. Im, Y. Jung, J.-W. Yoo, pH-responsive alginate-based microparticles for colon-targeted delivery of pure cyclosporine A crystals to treat ulcerative colitis, Pharmaceutics, 13 (2021) 1412. [link]
N. Hasan, J. Cao, J. Lee, H. Kim, J.-W. Yoo, Development of clindamycin-loaded alginate/pectin/hyaluronic acid composite hydrogel film for the treatment of MRSA-infected wounds, Journal of Pharmaceutical Investigation, 51 (2021) 597-610. [link]
J. Lee, S.P. Hlaing, N. Hasan, D. Kwak, H. Kim, J. Cao, I.-S. Yoon, H. Yun, Y. Jung, J.-W. Yoo, Tumor-penetrable nitric oxide-releasing nanoparticles potentiate local antimelanoma therapy, ACS Applied Materials & Interfaces, 13 (2021) 30383-30396. [link]
M. Naeem, J. Lee, M.A. Oshi, J. Cao, S.P. Hlaing, E. Im, Y. Jung, J.-W. Yoo, Colitis-targeted hybrid nanoparticles-in-microparticles system for the treatment of ulcerative colitis, Acta Biomaterialia, 116 (2020) 368-382. [link]
J. Cao, M. Su, N. Hasan, J. Lee, D. Kwak, D.Y. Kim, K. Kim, E.H. Lee, J.H. Jung, J.-W. Yoo, Nitric oxide-releasing thermoresponsive pluronic F127/alginate hydrogel for enhanced antibacterial activity and accelerated healing of infected wounds, Pharmaceutics, 12 (2020) 926. [link]
S.P. Hlaing, J. Kim, J. Lee, D. Kwak, H. Kim, J.-W. Yoo, Enhanced viability of probiotics against gastric acid by one-step coating process with poly-L-lysine: in vitro and in vivo evaluation, Pharmaceutics, 12 (2020) 662. [link]
J. Lee, D. Kwak, H. Kim, J. Kim, S.P. Hlaing, N. Hasan, J. Cao, J.-W. Yoo, Nitric oxide-releasing S-nitrosoglutathione-conjugated poly (lactic-co-glycolic acid) nanoparticles for the treatment of MRSA-infected cutaneous wounds, Pharmaceutics, 12 (2020) 618. [link]
M.A. Oshi, J. Lee, M. Naeem, N. Hasan, J. Kim, H.J. Kim, E.H. Lee, Y. Jung, J.-W. Yoo, Curcumin nanocrystal/pH-responsive polyelectrolyte multilayer core–shell nanoparticles for inflammation-targeted alleviation of ulcerative colitis, Biomacromolecules, 21 (2020) 3571-3581. [link]
J. Lee, S.P. Hlaing, J. Cao, N. Hasan, J.-W. Yoo, In vitro and in vivo evaluation of a novel nitric oxide-releasing ointment for the treatment of methicillin-resistant Staphylococcus aureus-infected wounds, Journal of Pharmaceutical Investigation, 50 (2020) 505-512. [link]
M. Choi, N. Hasan, J. Cao, J. Lee, S.P. Hlaing, J.-W. Yoo, Chitosan-based nitric oxide-releasing dressing for anti-biofilm and in vivo healing activities in MRSA biofilm-infected wounds, International Journal of Biological Macromolecules, 142 (2019) 680-692. [link]
M. Naeem, U.A. Awan, F. Subhan, J. Cao, S.P. Hlaing, J. Lee, E. Im, Y. Jung, J.-W. Yoo, Advances in colon-targeted nano-drug delivery systems: challenges and solutions, Archives of pharmacal research, 43 (2020) 153-169. [link]
N. Hasan, J. Cao, J. Lee, M. Naeem, S.P. Hlaing, J. Kim, Y. Jung, B.-L. Lee, J.-W. Yoo, PEI/NONOates-doped PLGA nanoparticles for eradicating methicillin-resistant Staphylococcus aureus biofilm in diabetic wounds via binding to the biofilm matrix, Materials Science and Engineering: C, 103 (2019) 109741. [link]
J. Lee, S.P. Hlaing, J. Cao, N. Hasan, H.-J. Ahn, K.-W. Song, J.-W. Yoo, In situ hydrogel-forming/nitric oxide-releasing wound dressing for enhanced antibacterial activity and healing in mice with infected wounds, Pharmaceutics, 11 (2019) 496. [link]
N. Hasan, J. Cao, J. Lee, S.P. Hlaing, M.A. Oshi, M. Naeem, M.-H. Ki, B.L. Lee, Y. Jung, J.-W. Yoo, Bacteria-targeted clindamycin loaded polymeric nanoparticles: Effect of surface charge on nanoparticle adhesion to MRSA, antibacterial activity, and wound healing, Pharmaceutics, 11 (2019) 236. [link]
J. Cao, J.-S. Choi, M.A. Oshi, J. Lee, N. Hasan, J. Kim, J.-W. Yoo, Development of PLGA micro-and nanorods with high capacity of surface ligand conjugation for enhanced targeted delivery, Asian Journal of Pharmaceutical Sciences, 14 (2019) 86-94. [link]
H. Banna, N. Hasan, J. Lee, J. Kim, J. Cao, E.H. Lee, H.R. Moon, H.Y. Chung, J.-W. Yoo, In vitro and in vivo evaluation of MHY908-loaded nanostructured lipid carriers for the topical treatment of hyperpigmentation, Journal of Drug Delivery Science and Technology, 48 (2018) 457-465. [link]
S.P. Hlaing, J. Kim, J. Lee, N. Hasan, J. Cao, M. Naeem, E.H. Lee, J.H. Shin, Y. Jung, B.-L. Lee, S-Nitrosoglutathione loaded poly (lactic-co-glycolic acid) microparticles for prolonged nitric oxide release and enhanced healing of methicillin-resistant Staphylococcus aureus-infected wounds, European Journal of Pharmaceutics and Biopharmaceutics, 132 (2018) 94-102. [link]
M.A. Oshi, M. Naeem, J. Bae, J. Kim, J. Lee, N. Hasan, W. Kim, E. Im, Y. Jung, J.-W. Yoo, Colon-targeted dexamethasone microcrystals with pH-sensitive chitosan/alginate/Eudragit S multilayers for the treatment of inflammatory bowel disease, Carbohydrate polymers, 198 (2018) 434-442. [link]
M. Naeem, M.A. Oshi, J. Kim, J. Lee, J. Cao, H. Nurhasni, E. Im, Y. Jung, J.-W. Yoo, pH-triggered surface charge-reversal nanoparticles alleviate experimental murine colitis via selective accumulation in inflamed colon regions, Nanomedicine: Nanotechnology, Biology and Medicine, 14 (2018) 823-834. [link]