The laboratory is working on understanding the molecular mechanisms by which leukemia and ovarian cancer cells survive extensive chemotherapy. We are engaged in several projects using a combination of genetic, bioinformatics, and biochemical tools to analyze the functions of specific target proteins and their role in pathogenesis. The goal of our research is to uncover the underlying mechanisms of therapy resistance and to develop less toxic, highly effective molecularly-targeted therapies. One of our major focuses includes childhood leukemia as this group of patients suffers from long-term side effects of the current therapies.

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