Publications
OUR publications After the birth of JK LAB
We are working hard for the first publication!
PI's publications before the birth of JK LAB
Featured studies
Kim, J., Joshi, A., Frank, L., Ganguly K. (2023) Cortical–hippocampal coupling during manifold exploration in motor cortex. Nature, 613, 103-110. doi: 10.1038/s41586-022-05533-z.
It made an important discovery about the underlying neural basis of system consolidation of motor memory. While there is clear evidence that the hippocampus eventually transfers memories to cortex (i.e., ‘systems consolidation’), very little is known about the time course of transfer and how cortical representations are changed. Our study suggests a clear model that hippocampal sharp-wave ripples are associated with representational exploration in motor cortex during early motor learning and, after completion of exploration, hippocampal activity drops.
Kim, J., Gulati, T., Ganguly, K. (2019) Competing roles of slow oscillations and delta waves on memory consolidation versus forgetting. Cell, 179(2), 514-526. doi: 10.1016/j.cell.2019.08.040 (the cover article).
It provides ground findings that fill a gap between the leading theories about the role of sleep in memory processing, termed the “synaptic homeostasis hypothesis” (SHY) and the “active systems consolidation” concept. I founded the dissociable features of slow waves from the published data (Gulati et al., 2017) and designed and performed real time closed-loop optogenetic experiments in the behaving rats to test the role of two types of slow waves and then analyzed all data.
Kim, J., Guo, L., Hishinuma. A., Lemke, S., Ramanathan, D.S., Won. S., Ganguly, K. (2022) Recovery of consolidation after sleep following stroke – interaction of slow waves, spindles and GABA. Cell Reports, 38, 110426, doi: 10.1016/j.celrep.2022.110426.
It uses a novel distinction of spindle coupling to global slow-oscillations (SO) and local delta-waves (δ) found in my Cell publication (Kim et al., 2019) to show that post-stroke sleep is in a “forget state.” We found that the pathological sleep in forget state after stroke results in poor motor memory consolidation. Exciting part is the use of a pharmacological treatment (α5-GABAA receptor antagonist which reduces tonic inhibition) to alter sleep processing towards a physiological state during the early stroke period.
Kim, H. **, Kim, J.**, Khanna, P., Griffin, S., Novik, L., Robert, J.M., Ganguly K. Rapid switching between bistable states during movement control (in preparation). ** co-first author
Darevsky, D. **, Kim, J.**, Ganguly K. Coupling of slow oscillations in prefrontal and motor cortex predicts onset of spindle trains and persistent memory reactivations (under revision). ** co-first author
Kim, J., Barath, A.S., Rusheen, A.E., Cabrera, J.R., Price, J.B., Shin, H., Jondal, D.E., Jang, D.P., Lee, K.H., Oh, Y. (2021) Automatic and reliable quantification of tonic dopamine concentrations in vivo using a novel probabilistic inference method. ACS Omega, 6, 6607-6613. doi: 10.1021/acsomega.0c05217
Kim, J., Oh, Y., Park, C., Kang, Y.M., Shin, H., Kim, I., Jang, D.P. (2019) Comparison study of partial least squares regression analysis and principal component analysis in fast scan cyclic voltammetry. International Journal of Electrochemical Science, 14, 5924-5937. doi: 10.20964/2019.07.03
Park, C., Oh, Y., Shin, H., Kim, J., Kang, Y., Sim, J., ... Jang, D.P. (2018). Fast cyclic square-wave voltammetry to enhance neurotransmitter selectivity and sensitivity. Analytical Chemistry, 90(22), 13348-13355. doi: 10.1021/acs.analchem.8b02920
Oh, Y., Heien, M.L., Park, C., Kang, Y.M., Kim, J., Boschen, S.L., ... Jang, D.P. (2018). Tracking tonic dopamine levels in vivo using multiple cyclic square wave voltammetry. Biosensors and Bioelectronics, 121, 174-182. doi: 10.1016/j.bios.2018.08.034
Kim, J., Fiorillo, C.D. (2017) Theory of optimal balance predicts and explains the amplitude and decay time of synaptic inhibition. Nature Communications, 8: 14566, doi: 10.1038/ncomms14566.
Fiorillo, C.D., Kim, J., Hong, S.Z. (2014) The meaning of spikes from the Neuron’s point of view: Predictive homeostasis generates the appearance of randomness. Frontiers in Computational Neuroscience, 29: 8-49, doi: 10.3389/fncom.2014.00049