Jingyan Fu Lab

Research Interest

Centrosome is a highly conserved organelle that serves as the main microtubule-organizing center in most animal cells. Its core component, the centriole, also provides a template for cilium assembly, a major signaling center during vertebrate development. Centrosome amplification is a hallmark of cancer; moreover, mutations in centrosome proteins are found in a wide range of human genetic diseases including microcephaly and ciliopathies that affect kidney, eye, liver and brain.

Our major goal is to assemble a dynamic 3D landscape of the centrosome pinpointing the spatial-temporal organization of its individual structural components in dividing and differentiating cells. We use both Drosophila and human cells as our model systems, and various super-resolution microscopy and biochemical approaches to paint the distribution and orientation of proteins and analyze the protein-protein interactions. We also study proteins that interact with centrosomes to promote specific functions during the cell cycle. Knowledge of where, when and how centrosomal proteins are pieced together provides us the clues to manipulate the centrosomal pathways and study how the defective centrosomes might compromise the cellular activities, developmental events and tissue homeostasis. This will illuminate our understanding on the molecular mechanism of the centrosome-related diseases.

Jingyan Fu, Ph.D.

Professor

College of Biological Sciences

China Agricultural University

Beijing 100193

China

Tel (lab): +86-10-62734755

Tel (office): +86-10-62734756

E-mail: jingyanfu@cau.edu.cn

University website: http://cbs.cau.edu.cn/art/2018/9/14/art_31829_585934.html

Current Lab Members

Selected Publications

(*Corresponding author; #Co-first author)

Tian Y#, Yan Y#, Fu J* (2022) Nine-fold symmetry of centriole: the joint efforts of its core proteins. Bioessays 44(3): e2100262.
Tian Y, Wei C, He J, Yan Y, Pang N, Fang X, Liang X, Fu J* (2021) Superresolution characterization of core centriole architecture. The Journal of Cell Biology 220(4): e202005103.
Fu J* and Zhang CM* (2019) Super-resolution microscopy: successful applications in centrosome study and beyond. Biophysics Reports 5(5-6): 235–243.
Fu J* and Glover DM (2016) How the newborn centriole becomes a mother. Cell Cycle 15(12): 1521-1522.
Fu J*, Lipinszki Z, Rangone H, Min M, Mykura C, Chao-Chu J, Schneider S, Dzhindzhev N, Gottardo M, Riparbelli M, Callaini G and Glover DM (2016) Conserved molecular interactions in centriole-to-centrosome conversion. Nature Cell Biology 18(1): 87-99. Commented in: Nature Reviews Molecular Cell Biology 17(1): 4.
Fu J#, Bian M#, Xin G, Deng Z, Luo J, Guo X, Chen H, Wang Y, Jiang Q and Zhang CM* (2015) TPX2 phosphorylation maintains metaphase spindle length by regulating microtubule flux. The Journal of Cell Biology 210(3): 373-383.
Fu J, Hagan IM and Glover DM* (2015) The centrosome and its duplication cycle. Cold Spring Harbor Perspectives in Biology 7(2): a015800.
Fu J* and Glover DM (2012) Structured illumination of the interface between centriole and peri-centriolar material. Open Biology 2(8): 120104. (Cover story) Commented in: ScienceAAAS News ScienceShots, 21 Aug 2012; Nature Reviews Molecular Cell Biology 13(12): 749; Nature Cell Biology 14(11): 1126–1128.
Fu J, Jiang Q and Zhang CM* (2010) Coordination of Cell Cycle Events by Ran GTPase. Nature Education 3(9):32.
Fu J, Jiang Q and Zhang CM* (2010) Collaboration of Mitotic Kinases in Cell Cycle Control. Nature Education 3(9):82.
Fu J, Bian M, Liu J, Jiang Q and Zhang CM* (2009) A single amino acid change converts Aurora-A into Aurora-B-like kinase in terms of partner specificity and cellular function. Proceedings of the National Academy of Sciences of the United States of America 106(17): 6939-6944.
Fu J, Bian M, Jiang Q* and Zhang CM* (2007) Roles of Aurora kinases in mitosis and tumorigenesis. Molecular Cancer Research 5(1): 1-10.

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