My research in spatial modeling focuses on developing statistically rigorous and computationally efficient methods to analyze complex spatial and spatial-temporal data. Motivated by applications in environmental science and spatial transcriptomics, I work on scalable Bayesian and Gaussian process-based models that capture spatial structure and quantify uncertainty. This includes tools for handling large-scale satellite and sensor data with missingness, as well as statistical frameworks to guide experimental design in high-throughput spatial genomics. A key focus is enabling interpretable and robust inference across diverse spatial domains under real-world constraints.
Biomolecules, 13 (2), 221.
We review power analysis methods for bulk RNA-seq, single-cell RNA-seq, and spatial transcriptomics. While tools exist for bulk and single-cell experiments, spatial transcriptomics lacks formal guidelines. We highlight key factors that influence power and offer practical insights for designing better experiments.
Submitted, 13 (2), 221.
We present spaDesign, a tool for planning spatial transcriptomics experiments. It helps figure out how much sequencing is needed to detect spatial patterns reliably. By simulating realistic scenarios, it supports power analysis across different spatial structures and sequencing depths, with applications to real 10X Visium data.