PUBLICATIONS

Structure-Based Analysis of Cefaclor Pharmacokinetic Diversity According to Human Peptide Transporter-1 Genetic Polymorphism

Ji-Hun Jang, Seung-Hyun Jeong

Int. J. Mol. Sci., 25(13), 6880 (2024). https://doi.org/10.3390/ijms25136880

Exploring gender differences in pharmacokinetics of central nervous system related medicines based on a systematic review approach

Seung-Min Lee, Ji-Hun Jang, Seung-Hyun Jeong

Naunyn Schmiedebergs Arch. Pharmacol., In-press (2024). https://doi.org/10.1007/s00210-024-03190-9

Quantitative summary on the human pharmacokinetic properties of cannabidiol to accelerate scientific clinical application of cannabis 

Ji-Hun Jang, Ju-Hwan Jeong, Seung-Hyun Jeong

Naunyn Schmiedebergs Arch. Pharmacol., In-press (2024). https://doi.org/10.1007/s00210-024-03185-6

Development of Hsp90 inhibitor to regulate cytokine storms in excessive delayed- and acute inflammation 

Hyun Bo Sim, Jun Sang Son, Sunil K. Gupta, Seung-Hyun Jeong, Yu-Jeong Choi, Ji Yeon Han, Sonny C. Ramos, Hyeongyeong Kim, Dae-Han Park, Ho Jin Yoo, Young Joo Yoo, Dong-Jo Chang, Seul-Ki Mun, Young Ho Seo, Jong-Jin Kim

Int. Immunopharmacol., 137, 112470 (2024). https://doi.org/10.1016/j.intimp.2024.112470

Pharmacokinetic Analysis of Levodropropizine and Its Potential Therapeutic Advantages Considering Eosinophil Levels and Clinical Indications

Ji-Hun Jang, Young-Jin Cho, Seung-Hyun Jeong

Pharmaceuticals, 17(2), 234 (2024). https://doi.org/10.3390/ph17020234

Is Gender an Important Factor in the Precision Medicine Approach to Levocetirizine?

Seung-Hyun Jeong, Ji-Hun Jang, Yong-Bok Lee

Pharmaceutics, 16(1), 146 (2024). https://doi.org/10.3390/pharmaceutics16010146 

Sex differences in 4-tert-octylphenol toxicokinetics: Exploration of sex as an effective covariate through an in vivo modeling approach

Seung-Hyun Jeong, Ji-Hun Jang, Hea-Young Cho, Yong-Bok Lee

Toxicology, 502, 153733 (2024). https://doi.org/10.1016/j.tox.2024.153733 

Population pharmacokinetic modeling of levodropropizine: Extended application to comparative analysis between commercial formulations and exploration of pharmacokinetic effects of diet 

Seung-Hyun Jeong, Ji-Hun Jang, Yong-Bok Lee

Naunyn Schmiedebergs Arch. Pharmacol., 397, 4403-4418 (2024). https://doi.org/10.1007/s00210-023-02889-5 

Modeling population pharmacokinetics of morniflumate in healthy Korean men: extending pharmacometrics analysis to niflumic acid, its major active metabolite 

Seung-Hyun Jeong, Ji-Hun Jang, Yong-Bok Lee

Naunyn Schmiedebergs Arch. Pharmacol., 397, 843-856 (2024). https://doi.org/10.1007/s00210-023-02640-0 

Exploring Differences in Pharmacometrics of Rabeprazole between Genders via Population Pharmacokinetic–Pharmacodynamic Modeling

Seung-Hyun Jeong, Ji-Hun Jang, Yong-Bok Lee

Biomedicines, 11(11), 3021 (2023). https://doi.org/10.3390/ biomedicines11113021 

A population pharmacokinetic model for individualized regimens of finasteride according to CYP3A5 genotype and liver function

Ji-Hun Jang, Seung-Hyun Jeong, Yong-Bok Lee

J. Pharm. Investig., 53, 857-868 (2023). https://doi.org/10.1007/s40005-023-00638-7 

P-glycoprotein mechanical functional analysis using in silico molecular modeling: Pharmacokinetic variability according to ABCB1 c.2677G > T/A genetic polymorphisms

Seung-Hyun Jeong, Ji-Hun Jang, Yong-Bok Lee

Int. J. Biol. Macromol., 249, 126777 (2023). https://doi.org/10.1016/j.ijbiomac.2023.126777 

Inter-individual exposure variability interpretation through reflection of biological age algorithm in physiologically based toxicokinetic model: Application to human risk assessment of di-isobutyl-phthalate 

Seung-Hyun Jeong, Ji-Hun Jang, Yong-Bok Lee

Environ. Pollut., 336, 122388 (2023). https://doi.org/10.1016/j.envpol.2023.122388 

Quantitative assessment of the relevance of organic-anion-transporting-polypeptide 1B1 and 2B1 polymorphisms in fexofenadine pharmacokinetic variants via pharmacometrics

Ji-Hun Jang, Seung-Hyun Jeong, Yong-Bok Lee

J. Pharm. Anal., 13(6), 660-672 (2023). https://doi.org/10.1016/j.jpha.2023.04.001 

Establishment of a fexofenadine population pharmacokinetic (PK)–pharmacodynamic (PD) model and exploration of dosing regimens through simulation

Ji-Hun Jang, Seung-Hyun Jeong, Yong-Bok Lee

J. Pharm. Investig., 53, 427-441 (2023). https://doi.org/10.1007/s40005-023-00615-0 

Population Pharmacokinetic Modeling of Zaltoprofen in Healthy Adults: Exploring the Dosage Regimen

Ji-Hun Jang, Seung-Hyun Jeong, Yong-Bok Lee

Pharmaceuticals, 16(2), 161 (2023). https://doi.org/10.3390/ph16020161

Dosage exploration of meloxicam according to CYP2C9 genetic polymorphisms based on a population pharmacokinetic-pharmacodynamic model

Ji-Hun Jang, Seung-Hyun Jeong, Yong-Bok Lee

Pharmacotherapy, 43, 145-157 (2023). https://doi.org/10.1002/phar.2762

Drug delivery to the brain via the nasal route of administration: Exploration of key targets and major consideration factors

Seung-Hyun Jeong, Ji-Hun Jang, Yong-Bok Lee

J. Pharm. Investig., 53, 119-152 (2023). https://doi.org/10.1007/s40005-022-00589-5

Torsemide Pharmacometrics in Healthy Adult Populations Including CYP2C9 Genetic Polymorphisms and Various Patient Groups through Physiologically Based Pharmacokinetic-Pharmacodynamic Modeling 

Seung-Hyun Jeong, Ji-Hun Jang, Yong-Bok Lee

Pharmaceutics, 14(12), 2720 (2022). https://doi.org/10.3390/pharmaceutics14122720

Physiologically based pharmacokinetic (PBPK) modeling of lornoxicam: Exploration of doses for CYP2C9 genotypes and patients with cirrhosis

Seung-Hyun Jeong, Ji-Hun Jang, Yong-Bok Lee

J. Pharm. Sci., 111(11), 3174-3184 (2022). https://doi.org/10.1016/j.xphs.2022.08.035

Development of physiologically-based toxicokinetic-toxicodynamic (PBTK-TD) model for 4-nonylphenol (4-NP) reflecting physiological changes according to age in males: Application as a new risk assessment tool with a focus on toxicodynamics

Seung-Hyun Jeong, Ji-Hun Jang, Yong-Bok Lee

Environ. Pollut., 312, 120041 (2022). https://doi.org/10.1016/j.envpol.2022.120041

Human risk assessment of 4-n-nonylphenol (4-n-NP) using physiologically-based pharmacokinetic (PBPK) modeling: Analysis of gender exposure differences and application to exposure analysis related to large exposure variability in population

Seung-Hyun Jeong, Ji-Hun Jang, Hea-Young Cho, Yong-Bok Lee

Arch. Toxicol., 96(10), 2687-2715 (2022). https://doi.org/10.1007/s00204-022-03328-9

Population Pharmacokinetic (Pop-PK) Analysis of Torsemide in Healthy Korean Males Considering CYP2C9 and OATP1B1 Genetic Polymorphisms

Seung-Hyun Jeong, Ji-Hun Jang, Hea-Young Cho, Yong-Bok Lee

Pharmaceutics, 14(4), 771 (2022). https://doi.org/10.3390/pharmaceutics14040771

Population pharmacokinetic analysis of lornoxicam in healthy Korean males considering creatinine clearance and CYP2C9 genetic polymorphism

Seung-Hyun Jeong, Ji-Hun Jang, Yong-Bok Lee

J. Pharm. Investig., 52(1), 109-127 (2022). https://doi.org/10.1007/s40005-021-00550-y

Toxicokinetic studies of di-isobutyl phthalate focusing on the exploration of gender differences in rats

Seung-Hyun Jeong, Ji-Hun Jang, Hea-Young Cho, Yong-Bok Lee

Chemosphere, 286(Part1), 131706 (2022). https://doi.org/10.1016/j.chemosphere.2021.131706

Toxicokinetics of di-isodecyl phthalate and its major metabolites in rats through the application of a developed and validated UHPLC-ESI-MS/MS method

Seung-Hyun Jeong, Ji-Hun Jang, Hea-Young Cho, Yong-Bok Lee

Arch. Toxicol., 95(11), 3515-3537 (2021). https://doi.org/10.1007/s00204-021-03153-6

Oral and Lymphatic Delivery of Paclitaxel via Lipid Nanocapsules

Phuong Tran, Ji-Hun Jang, Seung-Hyun Jeong, Yong-Bok Lee

Yakhak Hoeji, 65(5), 375-385 (2021). https://doi.org/10.17480/psk.2021.65.5.375

Pharmacokinetic Comparison between Methotrexate-Loaded Nanoparticles and Nanoemulsions as Hard- and Soft-Type Nanoformulations: A Population Pharmacokinetic Modeling Approach

Seung-Hyun Jeong, Ji-Hun Jang, Yong-Bok Lee

Pharmaceutics, 13(7), 1050 (2021). https://doi.org/10.3390/pharmaceutics13071050

Oral delivery of topotecan in polymeric nanoparticles: Lymphatic distribution and pharmacokinetics

Seung-Hyun Jeong, Ji-Hun Jang, Yong-Bok Lee

J. Control. Release, 335, 86-102 (2021). https://doi.org/10.1016/j.jconrel.2021.05.017

Human risk assessment of di-isobutyl phthalate through the application of a developed physiologically based pharmacokinetic model of di-isobutyl phthalate and its major metabolite mono-isobutyl phthalate

Seung-Hyun Jeong, Ji-Hun Jang, Hea-Young Cho, Yong-Bok Lee

Arch. Toxicol., 95(7), 2385-2402 (2021). https://doi.org/10.1007/s00204-021-03057-5

Simultaneous determination of fourteen components of Gumiganghwal-tang tablet in human plasma by UPLC-ESI-MS/MS and its application to pharmacokinetic study

Seung-Hyun Jeong, Ji-Hun Jang, Guk-Yeo Lee, Seung-Jung Yang, Hea-Young Cho, Yong-Bok Lee

J. Pharm. Anal., 11(4), 444-457 (2021). https://doi.org/10.1016/j.jpha.2020.08.003

Pharmacokinetic comparison with different assays for simultaneous determination of cis-, trans-cefprozil diastereomers in human plasma

Seung-Hyun Jeong, Ji-Hun Jang, Hea-Young Cho, Yong-Bok Lee

J. Pharm. Anal., 11(3), 351-363 (2021). https://doi.org/10.1016/j.jpha.2020.07.001

Population Pharmacokinetic Analysis of Cefaclor in Healthy Korean Subjects

Seung-Hyun Jeong, Ji-Hun Jang, Hea-Young Cho, Yong-Bok Lee

Pharmaceutics, 13(5), 754 (2021). https://doi.org/10.3390/pharmaceutics13050754

Pharmacokinetic Changes According to Single or Multiple Oral Administrations of Socheongryong-Tang to Rats: Presented as a Typical Example of Changes in the Pharmacokinetics Following Multiple Exposures to Herbal Medicines

Seung-Hyun Jeong, Ji-Hun Jang, Da-Hwa Jung, Guk-Yeo Lee, Yong-Bok Lee

Pharmaceutics, 13(4), 478 (2021). https://doi.org/10.3390/pharmaceutics13040478

Simultaneous determination of asarinin, β-eudesmol, and wogonin in rats using ultraperformance liquid chromatography–tandem mass spectrometry and its application to pharmacokinetic studies following administration of standards and Gumiganghwal-tang

Seung-Hyun Jeong, Ji-Hun Jang, Hea-Young Cho, Yong-Bok Lee

Biomed. Chromatogr., 35(4), e5021 (2021). https://doi.org/10.1002/bmc.5021

In vivo and in vitro studies of Banhahoobak-tang tablets using UPLC-ESI-MS/MS with polarity switching

Seung-Hyun Jeong, Ji-Hun Jang, Guk-Yeo Lee, Seung-Jung Yang, Hea-Young Cho, Yong-Bok Lee

J. Pharm. Biomed. Anal., 196, 113911 (2021). https://doi.org/10.1016/j.jpba.2021.113931

Simultaneous determination of three iridoid glycosides of Rehmannia glutinosa in rat biological samples using a validated hydrophilic interaction-UHPLC-MS/MS method in pharmacokinetic and in vitro studies

Seung-Hyun Jeong, Ji-Hun Jang, Hea-Young Cho, Yong-Bok Lee

J. Sep. Sci., 43(22), 4148-4161 (2020). https://doi.org/10.1002/jssc.202000809

Enhanced lymphatic delivery of methotrexate using W/O/W nanoemulsion: In vitro characterization and pharmacokinetic study

Ji-Hun Jang, Seung-Hyun Jeong, Yong-Bok Lee

Pharmaceutics, 12(10), 978 (2020). https://doi.org/10.3390/pharmaceutics12100978

Toxicokinetics of diisobutyl phthalate and its major metabolite, monoisobutyl phthalate, in rats: UPLC-ESI-MS/MS method development for the simultaneous determination of diisobutyl phthalate and its major metabolite, monoisobutyl phthalate, in rat plasma, urine, feces, and 11 various tissues collected from a toxicokinetic study

Seung-Hyun Jeong, Ji-Hun Jang, Hea-Young Cho, Yong-Bok Lee

Food Chem. Toxicol., 145, 111747 (2020). https://doi.org/10.1016/j.fct.2020.111747

Pharmacokinetic Comparison of Three Different Administration Routes for Topotecan Hydrochloride in Rats

Seung-Hyun Jeong, Ji-Hun Jang, Yong-Bok Lee

Pharmaceuticals, 13(9), 231 (2020). https://doi.org/10.3390/ph13090231

Simultaneous measurement of epinastine and its metabolite, 9,13b-dehydroepinastine, in human plasma by a newly developed ultra-performance liquid chromatography–tandem mass spectrometry and its application to pharmacokinetic studies

Seung-Hyun Jeong, Ji-Hun Jang, Hea-Young Cho, Yong-Bok Lee

Biomed. Chromatogr., 34(9), e4848 (2020). https://doi.org/10.1002/bmc.4848

Risk assessment for humans using physiologically based pharmacokinetic model of diethyl phthalate and its major metabolite, monoethyl phthalate

Seung-Hyun Jeong, Ji-Hun Jang, Hea-Young Cho, Yong-Bok Lee

Arch. Toxicol., 94(7), 2377-2400 (2020). https://doi.org/10.1007/s00204-020-02748-9

Population Pharmacokinetic Analysis of Tiropramide in Healthy Korean Subjects

Seung-Hyun Jeong, Ji-Hun Jang, Hea-Young Cho, Yong-Bok Lee

Pharmaceutics, 12(4), 374 (2020). https://doi.org/10.3390/pharmaceutics12040374

A sensitive UPLC–ESI–MS/MS method for the quantification of cinnamic acid in vivo and in vitro: application to pharmacokinetic and protein binding study in human plasma

Seung-Hyun Jeong, Ji-Hun Jang, Hea-Young Cho, In-Joon Oh, Yong-Bok Lee

J. Pharm. Investig., 50(2), 159-172 (2020). https://doi.org/10.1007/s40005-019-00444-0

Pharmacokinetic Comparison of Epinastine Using Developed Human Plasma Assays

Seung-Hyun Jeong, Ji-Hun Jang, Hea-Young Cho, Yong-Bok Lee

Molecules, 25(1), 209 (2020). https://doi.org/10.3390/molecules25010209

Gender differences in pharmacokinetics and tissue distribution of 4-n-nonylphenol in rats

Seung-Hyun Jeong, Ji-Hun Jang, Hea-Young Cho, Yong-Bok Lee

Arch. Toxicol., 93(11), 3121-3139 (2019). https://doi.org/10.1007/s00204-019-02581-9

Population Pharmacokinetics of Cis-, Trans-, and Total Cefprozil in Healthy Male Koreans

Ji-Hun Jang, Seung-Hyun Jeong, Hea-Young Cho, Yong-Bok Lee

Pharmaceutics, 11(10), 531 (2019). https://doi.org/10.3390/pharmaceutics11100531

Simultaneous determination of fourteen main active components in Gumiganghwal-tang tablet by using a newly developed UPLC-ESI-MS/MS method

Seung-Hyun Jeong, Ji-Hun Jang, Guk-Yeo Lee, Seung-Jung Yang, Hea-Young Cho, Yong-Bok Lee

J. Chromatogr. B, 1126-1127, 121743 (2019). https://doi.org/10.1016/j.jchromb.2019.121743

A novel and sensitive UPLC–MS/MS method to determine mequitazine in rat plasma and urine: Validation and its application to pharmacokinetic studies

Seung-Hyun Jeong, Ji-Hun Jang, Yong-Bok Lee

Biomed. Chromatogr., 33(10), e4627 (2019). https://doi.org/10.1002/bmc.4627

Simultaneous determination of diethyl phthalate and its major metabolite, monoethyl phthalate, in rat plasma, urine, and various tissues collected from a toxicokinetic study by ultrahigh performance liquid chromatography-tandem mass spectrometry

Seung-Hyun Jeong, Ji-Hun Jang, Hea-Young Cho, Yong-Bok Lee

J. Pharm. Biomed. Anal., 173, 108-119 (2019). https://doi.org/10.1016/j.jpba.2019.05.027

Preparation and in vitro/in vivo characterization of polymeric nanoparticles containing methotrexate to improve lymphatic delivery

Ji-Hun Jang, Seung-Hyun Jeong, Yong-Bok Lee

Int. J. Mol. Sci., 20(13), 3312 (2019). https://doi.org/10.3390/ijms20133312

Comparison of UPLC-MS/MS and HPLC-UV methods for the determination of zaltoprofen in human plasma

Ji-Hun Jang, Seung-Hyun Jeong, Hea-Young Cho, Yong-Bok Lee

J. Pharm. Investig., 49(6), 613-624 (2019). https://doi.org/10.1007/s40005-018-00416-w

Simultaneous UPLC-MS/MS determination of four components of Socheongryong-tang tablet in human plasma: Application to pharmacokinetic study

Seung-Hyun Jeong, Ji-Hun Jang, Seong-Ho Ham, Seung-Jung Yang, Hea-Young Cho, Yong-Bok Lee

J. Chromatogr. B, 1095, 214-225 (2018). https://doi.org/10.1016/j.jchromb.2018.07.043

Soft- and hard-lipid nanoparticles: a novel approach to lymphatic drug delivery

Seung-Hyun Jeong, Ji-Hun Jang, Hea-Young Cho, Yong-Bok Lee

Arch. Pharm. Res., 41(8), 797-814 (2018). https://doi.org/10.1007/s12272-018-1060-0