James Goydos, M.D., F.A.C.S - Publications

• Randomized controlled trial of the mySmartSkin web-based intervention to promote skin self-examination and sun protection behaviors among individuals diagnosed with melanoma: study design and baseline characteristics

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• Supplementary Material 1

• Facebook Intervention for Young-Onset Melanoma Patients and Their Family Members: Pilot and Feasibility Study

• Participation of xCT in melanoma cell proliferation in vitro and tumorigenesis in vivo

• A phase II trial of riluzole, an antagonist of metabotropic glutamate receptor 1 (GRM1) signaling, in patients with advanced melanoma

• Exosomes released by metabotropic glutamate receptor 1 (GRM1) expressing melanoma cells increase cell migration and invasiveness

• Parent and Child Characteristics Associated with Child Sunburn and Sun Protection Among U.S. Hispanics

• The transcription factor RUNX2 regulates receptor tyrosine kinase expression in melanoma

• Final Results of the Sunbelt Melanoma Trial: A Multi-Institutional Prospective Randomized Phase III Study Evaluating the Role of Adjuvant High-Dose Interferon Alfa-2b and Completion Lymph Node Dissection for Patients Staged by Sentinel Lymph Node Biopsy

• Receptivity to Internet-Delivered Interventions to Promote Skin Self-examination and Sun Protection Behaviors in Patients With Melanoma

• Skin self-examination behaviors among individuals diagnosed with melanoma

• Targeting Glutamatergic Signaling and the PI3 Kinase Pathway to Halt Melanoma Progression 1 2

• Riluzole is a Radio-Sensitizing Agent in an in vivo Model of Brain Metastasis Derived from GRM1 Expressing Human Melanoma Cells

• Interdigitating Dendritic Cell Sarcoma Presenting in the Skin: Diagnosis and the Role of Surgical Resection, Chemotherapy and Radiotherapy in Management

• Methods and compositions for treating cancer

• Supplementary Material

• Epac1 increases migration of endothelial cells and melanoma cells via FGF2-mediated paracrine signaling

• RUNX2 is overexpressed in melanoma cells and mediates their migration and invasion

• Metabotropic glutamate receptor 1 (mGluR1) mediates melanocyte transformation via transactivation of IGF-1 Receptor

• Store-Operated Ca2+ Entry (SOCE) Regulates Melanoma Proliferation and Cell Migration

• Psychosocial Correlates of Sun Protection Behaviors among U.S. Hispanic Adults

• Activation of the Glutamate Receptor GRM1 Enhances Angiogenic Signaling to Drive Melanoma Progression

• Metabotropic Glutamate Receptor-1 Contributes to Progression in Triple Negative Breast Cancer

• Disruption of GRM1-mediated signalling using riluzole results in DNA damage in melanoma cells

• Linguistic Acculturation and Skin Cancer-Related Behaviors Among Hispanics in the Southern and Western United States

• Skin Cancer Surveillance Behaviors among U.S. Hispanic Adults

• Sun protection and exposure behaviors among Hispanic adults in the United States: differences according to acculturation and among Hispanic subgroups

• Non-Canonical Smads Phosphorylation Induced by the Glutamate Release Inhibitor, Riluzole, through GSK3 Activation in Melanoma

• Plant Lectin Can Target Receptors Containing Sialic Acid, Exemplified by Podoplanin, to Inhibit Transformed Cell Growth and Migration

• MDM4 is a key therapeutic target in cutaneous melanoma

• Functional Effects of GRM1 Suppression in Human Melanoma Cells

• Skin Cancer Screening Among Hispanic Adults in the United States: Results From the 2010 National Health Interview Survey

• A phase I trial of riluzole and sorafenib in patients with advanced solid tumors and melanoma.

• Glutamatergic Pathway Targeting in Melanoma: Single-Agent and Combinatorial Therapies

• Understanding Melanocyte Transformation A Work in Progress

• Gβγ subunits inhibit Epac-induced melanoma cell migration

• Constitutive Smad linker phosphorylation in melanoma: A mechanism of resistance to Transforming Growth Factor-β-mediated growth inhibition

• Epac1 promotes melanoma metastasis via modification of heparan sulfate

• Riluzole Enhances Ionizing Radiation-Induced Cytotoxicity in Human Melanoma Cells that Ectopically Express Metabotropic Glutamate Receptor 1 In Vitro and In Vivo

• Abstract 5321: Molecular analysis of melanoma-induced sentinel lymph node immune dysfunction

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• The Regulation of miRNA-211 Expression and Its Role in Melanoma Cell Invasiveness

• The EphB4 receptor promotes the growth of melanoma cells expressing the ephrin-B2 ligand

• Surveillance after surgical treatment of melanoma: Futility of routine chest radiography

• The Glutamate Release Inhibitor Riluzole Decreases Migration, Invasion, and Proliferation of Melanoma Cells

• Role of the G Protein-Coupled Receptor, mGlu1, in Melanoma Development

• GLI2-Mediated Melanoma Invasion and Metastasis

• Exchange Protein Directly Activated by Cyclic AMP Increases Melanoma Cell Migration by a Ca2+-Dependent Mechanism

• c-Jun Regulates Phosphoinositide-dependent Kinase 1 Transcription

• Factors Associated with False-Negative Sentinel Lymph Node Biopsy in Melanoma Patients

• C-JUN regulates PDK1 transcription: implication for AKT and PKC activities and melanoma tumorigenesis

• c-Jun regulates phosphoinositide-dependent kinase 1 transcription: implication for Akt and protein kinase C activities and melanoma tumorigenesis

• AKT2 is a downstream target of metabotropic glutamate receptor 1 (Grm1)

• A Phase 0 Trial of Riluzole in Patients with Resectable Stage III and IV Melanoma

• GLI2, A TGF-beta-inducible target, antagonizes M-MITF and promotes melanoma aggressiveness

• Phase II Trial of 17-Allylamino-17-Demethoxygeldanamycin in Patients with Metastatic Melanoma

• The ubiquitin ligase Siah2 regulates tumorigenesis and metastasis by HIF-dependent and -independent pathways

• Effect of multiple-nodal basin drainage on melanoma

• Final results of the Sunbelt Melanoma Trial

• Abstract LB-244: A phase 0 trial of riluzole in patients with resectable stage III or IV melanoma.

• Factors Associated With Improved Survival Among Young Adult Melanoma Patients Despite a Greater Incidence of Sentinel Lymph Node Metastasis

• Rewired ERK-JNK signaling pathways in melanoma

• Metabotropic Glutamate Receptor 1 and Glutamate Signaling in Human Melanoma

• Aberrant expression of metabotropic glutamate receptor 1 (GRM1) in human melanoma

• Melanoma Patients with Positive Sentinel Nodes Who Did Not Undergo Completion Lymphadenectomy: A Multi-Institutional Study

• Prospective Multi-Institutional Study of Reverse Transcriptase Polymerase Chain Reaction for Molecular Staging of Melanoma

• Gender-Related Differences in Outcome for Melanoma Patients

• Metabotropic glutamate receptor 1 activates the mitogen activated protein kinase (MAPK) pathway in breast cancer and melanoma

• Elevated metabotropic glutamate receptor expression: A novel finding in invasive breast cancer

• Tumor cell and circulating markers in melanoma: Diagnosis, prognosis, and management

• Detection of B-RAF and N-RAS mutations in human melanoma

• Lessons learned from the Sunbelt Melanoma Trial

• Extracellular cAMP-dependent protein kinase (ECPKA) in melanoma

• Multivariate prognostic model for patients with thick cutaneous melanoma: Results of a large multi-institutional study

• Detection of Mutations in the Mitogen-Activated Protein Kinase Pathway in Human Melanoma

• Vascular Endothelial Growth Factor C mRNA Expression Correlates with Stage of Progression in Patients with Melanoma

• Differential expression of vascular endothelial growth factor-A isoforms at different stages of melanoma progression

• The frequency of MAPK mutations differs by level of progression in melanoma

• Melanoma mouse model implicates metabotropic glutamate signaling in melanocytic neoplasia

• Patterns of recurrence in patients with melanoma and histologically negative but RT-PCR-positive sentinel lymph nodes

• Patterns of recurrence in patients with melanoma and histologically negative but RT-PCR-positive sentinel lymph nodes - Invited commentary - Reply

• NY-ESO-1 and CTp11 Expression May Correlate with Stage of Progression in Melanoma

• A Molecular Technique Useful in the Detection of Occult Metastases in Patients with Melanoma: RT-PCR Analysis of Sentinel Lymph Nodes and Peripheral Blood

• Prevention and early diagnosis of cutaneous melanoma

• Dynamic lymphoscintigraphy in 125 patients with cutaneous melanoma: Technical considerations employing filtered Tc-99m-sulfur colloid and correlation with sentinel lymphadenectomy.

• Use of lymphoscintigraphy in malignant melanoma

• Dynamic Lymphoscintigraphy in Intermediate Thickness Melanoma: Results of our First 100 Patients

• Use of sentinel node lymphoscintigraphy in malignant melanoma

• Minimally invasive staging of patients with melanoma: Sentinel lymphadenectomy and detection of the melanoma-specific proteins MART-1 and tyrosinase by reverse transcriptase polymerase chain reaction

• Sentinel Lymph Node Mapping in Melanoma of the Ear

• Goydos JS, Brumfield AM, Frezza E, Booth A, Lotze MT, Carty SE.Marked elevation of serum interleukin-6 in patients with cholangiocarcinoma: validation of utility as a clinical marker. Ann Surg 227: 398-404

• A phase I trial of a synthetic mucin peptide vaccine. Induction of specific immune reactivity in patients with adenocarcinoma.

• Supplemental Data Rewired ERK-JNK Signaling Pathways in Melanoma

In addition to his publications in peer-reviewed journals, Dr. James Goydos is regularly published across a myriad of platforms on topics pertaining for skin cancer, healthcare, medical technology, and more. You will find James Goydos' work featured on Medika Life, The Good Men Project, Newsbreak, Hubpages, Medium, Reedsy, Tumblr, Blogspot, Wordpress, and can subscribe to his social media channels on Facebook, Twitter, Instagram, Myspace, Refind, Goodreads, Pinterest, Reddit, Kaggle, Github, LinkedIn, Crunchbase, and Flipboard.