Palestrante: João Refundini

• Email: luca.refundini@aluno.ufabc.edu.br

• Twitter: @JoaoRefundini

Descrição: Introdução teórica ao tema de discussão do primeiro encontro de 2020 da Liga Acadêmica de Neurociência que será realizada no dia 10/09/20. Nesta apresentação serão abordados os conhecimentos de base necessários para possibilitar a leitura dos artigos científicos bem como acompanhar as discussões durante a Liga. (Tema: Sistema Nervoso e COVID )

Referências bibliográficas

• How to Talk About the Coronavirus: Four ways to help those around you be better informed about the pandemic - https://www.theatlantic.com/ideas/archive/2020/03/how-talk-about-coronavirus/609118/

• COVID-19 Dashboard by the Center for Systems Science and Engineering at Johns Hopkins University - https://www.arcgis.com/apps/opsdashboard/index.html#/bda7594740fd40299423467b48e9ecf6

• How does COVID-19 kill? Uncertainty is hampering doctors’ ability to choose treatments. Doctors are reaching for drugs that dampen the immune response — but these also undermine the body’s own fight against the coronavirus - https://www.arcgis.com/apps/opsdashboard/index.html#/bda7594740fd40299423467b48e9ecf6

• Forty years with coronaviruses - https://rupress.org/jem/article/217/5/e20200537/151597/Forty-years-with-coronavirusesForty-years-with

• Stop the coronavirus stigma now: The pandemic is fuelling deplorable racism and discrimination, especially against Asian people. Education and research will also pay the price - https://www.nature.com/articles/d41586-020-01009-0

• COVID-19: don’t forget deaf people - https://www.nature.com/articles/d41586-020-00782-2

• Trump ‘owes us an apology.’ Chinese scientist at the center of COVID-19 origin theories speaks out - https://www.sciencemag.org/news/2020/07/trump-owes-us-apology-chinese-scientist-center-covid-19-origin-theories-speaks-out

• Covid-19: Infectious coronaviruses 'circulating in bats for decades' - https://www.bbc.com/news/science-environment-53584936?utm_source=Nature+Briefing&utm_campaign=2a2293db4f-briefing-dy-20200730&utm_medium=email&utm_term=0_c9dfd39373-2a2293db4f-44824205

• Did pangolins spread the China coronavirus to people? Genetic sequences of viruses isolated from the scaly animals are 99% similar to that of the circulating virus — but the work is yet to be formally published. - https://www.nature.com/articles/d41586-020-00364-2

• Profile of a killer: the complex biology powering the coronavirus pandemic - Scientists are piecing together how SARS-CoV-2 operates, where it came from and what it might do next — but pressing questions remain about the source of COVID-19. - https://www.nature.com/articles/d41586-020-01315-7

• How to Draw the Coronavirus - https://www.theparisreview.org/blog/2020/05/18/how-to-draw-the-coronavirus/?utm_source=Nature+Briefing&utm_campaign=ce09fd130b-briefing-dy-20200526_COPY_01&utm_medium=email&utm_term=0_c9dfd39373-ce09fd130b-44824205

• The sprint to solve coronavirus protein structures — and disarm them with drugs: Stopping the pandemic could rely on breakneck efforts to visualize SARS-CoV-2 proteins and use them to design drugs and vaccines. - https://www.nature.com/articles/d41586-020-01444-z

• Bad News Wrapped in Protein: Inside the Coronavirus Genome - https://www.nytimes.com/interactive/2020/04/03/science/coronavirus-genome-bad-news-wrapped-in-protein.html?utm_source=Nature+Briefing&utm_campaign=d04639c3df-briefing-dy-20200406&utm_medium=email&utm_term=0_c9dfd39373-d04639c3df-44824205

• Nextstrain SARS-CoV-2 resources - nextstrain.org/sars-cov-2

• How Coronavirus Mutates and Spreads - https://www.nytimes.com/interactive/2020/04/30/science/coronavirus-mutations.html#:~:text=As%20the%20cell%20copies%20that,they%20randomly%20accumulate%20more%20mutations.

• Immune response in COVID-19: addressing a pharmacological challenge by targeting pathways triggered by SARS-CoV-2 -https://www.nature.com/articles/s41392-020-0191-1

• Extrapulmonary manifestations of COVID-19 - https://doi.org/10.1038/s41591-020-0968-3

• SARS-CoV-2 Receptor ACE2 is an Interferon-Stimulated gene in human airway epithelial cells and is detected in specific cell subsets across tissues - https://doi.org/10.1016/j.cell.2020.04.035

• Tissue-specific tolerance in fatal Covid-19 - https://www.medrxiv.org/content/10.1101/2020.07.02.20145003v1

• Pre-existing immunity to SARS-CoV-2: the knowns and unknowns - https://www.nature.com/articles/s41577-020-0389-z?utm_source=Nature+Briefing&utm_campaign=0dde152fa9-briefing-dy-20200710&utm_medium=email&utm_term=0_c9dfd39373-0dde152fa9-44824205

• SARS-CoV-2-reactive T cells in healthy donors and patients with COVID-19 - https://www.nature.com/articles/s41586-020-2598-9.epdf?sharing_token=7CsiyG4FJd0wdlqBz_2IRNRgN0jAjWel9jnR3ZoTv0PgJfv008O2hne4vflEmSmaqW9EbxQZJ50JQ8h6h3PPbNEh49WJB2_2gDzVUbt89WQDFeMyIVHZFVGSFDe7KN-Ii_He3kdOpvY0dM8qMlCEGYWtOzs9xxff4gD1Hg8LIyE%3D

• Humoral immune response and prolonged PCR positivity in a cohort of 1343 SARS-CoV 2 patients in the New York City region - https://www.medrxiv.org/content/10.1101/2020.04.30.20085613v1

• Beyond the Spike: identification of viral targets of the antibody response to SARS-CoV-2 in COVID-19 patients - https://www.medrxiv.org/content/10.1101/2020.04.30.20085670v1

• SARS-CoV-2 infection protects against rechallenge in rhesus macaques - https://science.sciencemag.org/content/369/6505/812#:~:text=Immunity%20from%20reinfection&text=generated%20rhesus%20macaque%20models%20of,protected%20against%20a%20second%20infection.

• Who is getting sick, and how sick? A breakdown of coronavirus risk by demographic factors - https://www.statnews.com/2020/03/03/who-is-getting-sick-and-how-sick-a-breakdown-of-coronavirus-risk-by-demographic-factors/?utm_source=Nature+Briefing&utm_campaign=0ebb957e06-briefing-dy-20200304&utm_medium=email&utm_term=0_c9dfd39373-0ebb957e06-44824205

• The coronavirus is most deadly if you are older and male — new data reveal the risks: A slew of detailed studies has now quantified the increased risk the virus poses to older people, men, and other groups. - https://www.nature.com/articles/d41586-020-02483-2

• How sick will the coronavirus make you? The answer may be in your genes - https://www.sciencemag.org/news/2020/03/how-sick-will-coronavirus-make-you-answer-may-be-your-genes

• Extrapulmonary manifestations of COVID-19. - https://doi.org/10.1038/s41591-020-0968-3

• Detection of Severe Acute Respiratory Syndrome Coronavirus in the Brain: Potential Role of the Chemokine Mig in Pathogenesis - https://academic.oup.com/cid/article/41/8/1089/377612

• Severe Acute Respiratory Syndrome Coronavirus Infection Causes Neuronal Death in the Absence of Encephalitis in Mice Transgenic for Human ACE2 - https://jvi.asm.org/content/82/15/7264

• Middle East Respiratory Syndrome Coronavirus Causes Multiple Organ Damage and Lethal Disease in Mice Transgenic for Human Dipeptidyl Peptidase 4 - https://academic.oup.com/jid/article/213/5/712/2459340

• The neuroinvasive potential of SARS‐CoV2 may play a role in the respiratory failure of COVID‐19 patients - https://onlinelibrary.wiley.com/doi/full/10.1002/jmv.25728

• Lifting the mask on neurological manifestations of COVID-19. - https://doi.org/10.1038/s41582-020-0398-3

• Lung innervation in the eye of a cytokine storm: neuroimmune interactions and COVID-19. -https://doi.org/10.1038/s41582-020-0402-y

• COVID-19 and possible links with Parkinson’s disease and parkinsonism: from bench to bedside. -https://doi.org/10.1038/s41531-020-00123-0

• Coronavirus vaccines: five key questions as trials begin -Some experts warn that accelerated testing will involve some risky trade-offs. - https://www.nature.com/articles/d41586-020-00798-8

• The race for coronavirus vaccines: a graphical guide - Eight ways in which scientists hope to provide immunity to SARS-CoV-2 - https://www.nature.com/articles/d41586-020-01221-y

• Evolution of the COVID-19 vaccine development landscape - https://www.nature.com/articles/d41573-020-00151-8?utm_source=Nature+Briefing&utm_campaign=3425a858d5-briefing-dy-20200904&utm_medium=email&utm_term=0_c9dfd39373-3425a858d5-44824205

• ChAdOx1 nCoV-19 vaccination prevents SARS-CoV-2 pneumonia in rhesus macaques - https://www.biorxiv.org/content/10.1101/2020.05.13.093195v1

• The line is forming for a COVID-19 vaccine. Who should be at the front? - https://www.sciencemag.org/news/2020/06/line-forming-covid-19-vaccine-who-should-be-front

• Antibody therapies could be a bridge to a coronavirus vaccine — but will the world benefit? - Monoclonal antibodies are complex and expensive to produce, meaning poor countries might be priced out. - https://www.nature.com/articles/d41586-020-02360-y

• Hopes rise for coronavirus drug remdesivir - Despite conflicting studies, results from largest trial yet show the antiviral speeds up recovery, putting it on track to become a standard of care in the United States. - https://www.nature.com/articles/d41586-020-01295-8

• Coronavirus breakthrough: dexamethasone is first drug shown to save lives - In a large trial, a cheap and widely available steroid cut deaths by one-third among patients critically ill with COVID-19. - https://www.nature.com/articles/d41586-020-01824-5