2025
Kim A, Jung S, Kim Y, Jung J, Lee S, Lee H, Kim MJ, Park JY, Hwang EM*, Lee J*. Novel function of TREK-1 in regulating adipocyte differentiation and lipid accumulation. Cell Death Dis. 2025 Mar 8;16(1):164.
Afridi R, Bhusal A, Lee SE, Hwang EM, Ryu H, Kim JH, Suk K. A microglial kinase ITK mediating neuroinflammation and behavioral deficits in traumatic brain injury. Mol Cell Neurosci. 2025 Jan 27;132:103994.
2024
Kim A, Bae Y, Gadhe CG, Jung HG, Yang E, Kim H, Lee J, Shim C, Sung YH, Noh J, Kim EJ, Kang D, Pae AN, Hwang EM*, Park JY*. Mice deficient in TWIK-1 are more susceptible to kainic acid-induced seizures. iScience. 2024 Dec 12;28(1):111587.
Bae Y, Lee S, Kim A, Lee S, Kim SS, Park S, Noh J, Ryoo K, Yi GS, Park JY*, Hwang EM*. Astrocytic NHERF-1 Increases Seizure Susceptibility by Inhibiting Surface Expression of TREK-1. Glia. 2024 Nov 14. doi: 10.1002/glia.24644.
Kim S, Chun H, Kim Y, Kim Y, Park U, Chu J, Bhalla M, Choi SH, Yousefian-Jazi A, Kim S, Hyeon SJ, Kim S, Kim Y, Ju YH, Lee SE, Lee H, Lee K, Oh SJ, Hwang EM, Lee J, Lee CJ, Ryu H. Astrocytic autophagy plasticity modulates Aβ clearance and cognitive function in Alzheimer's disease. Mol Neurodegener. 2024 Jul 23;19(1):55.
Bhusal A, Kim JH, Kim SC, Hwang EM, Ryu H, Ali MS, Park SC, Lee WH, Suk K. The microglial innate immune protein PGLYRP1 mediates neuroinflammation and consequent behavioral changes. Cell Rep. 2024 Mar 26;43(3):113813.
2023
Jun S, Kim M, Park H, Hwang EM, Yamamoto Y, Tanaka-Yamamoto K. Organization of Purkinje cell development by neuronal MEGF11 in cerebellar granule cells. Cell Rep. 2023 Sep 26;42(9):113137.
Lee EH, Park JE, Gotina L, Han YE, Viswanath ANI, Yoo S, Moon B, Hwang JY, Park WK, Cho Y, Song C, Min SJ, Hwang EM, Lee H, Pae AN, Roh EJ, Oh SJ. Novel potent blockers for TWIK-1/TREK-1 heterodimers as potential antidepressants. Biomed Pharmacother. 2023 Jul 14;165:115139.
Kim H, Choi M, Han S, Park SY, Jeong M, Kim SR, Hwang EM*, Lee SG*. Expression patterns of AEG-1 in the normal brain. Brain Struct Funct. 2023 Jul 8.
Hwang EM, Lee BH, Byun EH, Lee S, Kang D, Lee DK, Song MS, Hong SG. Monitoring trafficking and expression of hemagglutinin-tagged transient receptor potential melastatin 4 channel in mammalian cells. Korean J Physiol Pharmacol. 2023 Jul 1;27(4):417-426.
Kim SS, Park J, Kim E, Hwang EM*, Park JY. β-COP Suppresses the Surface Expression of the TREK2. Cells. 2023 May 29;12(11):1500.
Cho E, Park J, Hwang EM, Kim HW, Park JY. 14-3-3γ haploinsufficiency leads to altered dopamine pathway and Parkinson's disease-like motor incoordination in mice. Mol Brain. 2023 Jan 5;16(1):2.
2022
Kim SC, Park JY, Hwang EM. Caspase-dependent apoptosis induces reactivation and gliogenesis of astrocytes in adult mice. Front Cell Neurosci. 2022 Nov 30;16:1054956.
Kim SS, Bae Y, Kwon O, Kwon SH, Seo JB, Hwang EM, Park JY. β-COP Regulates TWIK1/TREK1 Heterodimeric Channel-Mediated Passive Conductance in Astrocytes. Cells. 2022 Oct 21;11(20):3322.
Bhusal A, Nam Y, Seo D, Rahman MH, Hwang EM, Kim SC, Lee WH, Suk K. Cathelicidin-related antimicrobial peptide promotes neuroinflammation through astrocyte-microglia communication in experimental autoimmune encephalomyelitis. Glia. 2022 Jun 7. doi: 10.1002/glia.24227.
Lee YS, Kwon O, Jeong GR, Noh J, Kim SE, Yi GS, Hwang EM, Park JY. Deficiency of TTYH1 Expression Reduces the Migration and Invasion of U2OS Human Osteosarcoma Cells. Life (Basel). 2022 Apr 3;12(4):530.
Yarishkin O, Phuong TTT, Vazquez-Chona F, Bertrand J, van Battenburg-Sherwood J, Redmon SN, Rudzitis CN, Lakk M, Baumann JM, Freichel M, Hwang EM, Overby D, Križaj D. Emergent Temporal Signaling in Human Trabecular Meshwork Cells: Role of TRPV4-TRPM4 Interactions. Front Immunol. 2022 Mar 31;13:805076.
Song JG, Kwon O, Hwang EM, Kim HW, Park JY. Conditional deletion of TMEM16A in cholinergic neurons of the medial habenula induces anhedonic-like behavior in mice. Behav Brain Res. 2022 Mar 12:113841.
Kim JH, Kwon O, Bhusal A, Lee J, Hwang EM, Ryu H, Park JY, Suk K. Neuroinflammation Induced by Transgenic Expression of Lipocalin-2 in Astrocytes. Front Cell Neurosci. 2022 Feb 23;16:839118.
Kim SC, Kim A, Park JY, Hwang EM*. Improved AAV vector system for cell-type-specific RNA interference. J Neurosci Methods. 2022 Feb 15;368:109452.
2021
Kwon O, Yang H, Kim SC, Kim J, Sim J, Lee J, Hwang EM, Shim S, Park JY. TWIK-1 BAC-GFP Transgenic Mice, an Animal Model for TWIK-1 Expression. Cells. 2021 Oct 14;10(10):2751.
Han YM, Kim MS, Jo J, Shin D, Kwon SH, Seo JB, Kang D, Lee BD, Ryu H, Hwang EM, Kim JM, Patel PD, Lyons DM, Schatzberg AF, Her S. Decoding the temporal nature of brain GR activity in the NFκB signal transition leading to depressive-like behavior. Mol Psychiatry. 2021 Sep;26(9):5087-5096.
Hyeon SJ, Park J, Yoo J, Kim SH, Hwang YJ, Kim SC, Liu T, Shim HS, Kim Y, Cho Y, Woo J, Kim KS, Myers RH, Ryu HL, Kowall NW, Song EJ, Hwang EM, Seo H, Lee J, Ryu H. Dysfunction of X-linked inhibitor of apoptosis protein (XIAP) triggers neuropathological processes via altered p53 activity in Huntington's disease. Prog Neurobiol. 2021 Sep;204:102110.
Chung S, Yang J, Kim HJ, Hwang EM, Lee W, Suh K, Choi H, Mook-Jung I. Plexin-A4 mediates amyloid-β-induced tau pathology in Alzheimer's disease animal model. Prog Neurobiol. 2021 Aug;203:102075.
Kim JH, Jung HG, Kim A, Shim HS, Hyeon SJ, Lee YS, Han J, Jung JH, Lee J, Ryu H, Park JY, Hwang EM*, Suk K*. Hevin-calcyon interaction promotes synaptic reorganization after brain injury. Cell Death Differ. 2021 Sep;28(9):2571-2588.
Kim JH, Afridi R, Han J, Jung HG, Kim SC, Hwang EM, Shim HS, Ryu H, Choe Y, Hoe HS, Suk K. Gamma subunit of complement component 8 is a neuroinflammation inhibitor. Brain. 2021 Mar 3; 144(2)528-552.
Jung HG, Kim A, Kim SC, Park JY*, Hwang EM*. AEG-1 regulates TWIK-1 expression as an RNA-binding protein in astrocytes. Brain Sciences. 2021 Jan 11; 11(1): 85.
2020
Bae Y, Choi JH, Ryoo K, Kim A, Kwon O, Jung HG, Hwang EM*, Park JY*. Spadin Modulates Astrocytic Passive Conductance via Inhibition of TWIK-1/TREK-1 Heterodimeric Channels. Int J Mol Sci. 2020 Dec 17;21(24):9639.
Kim HR, Kim DH, An JY, Kang D, Park JW, Hwang EM, Seo EJ, Jang IH, Ha CM, Lee BJ. NELL2 Function in Axon Development of Hippocampal Neurons. Mol Cells. 2020 Jun 30;43(6):581-589.
Sim KM, Lee YS, Kim HJ, Cho CH, Yi GS, Park MJ, Hwang EM*, Park JY*. Suppression of CaMKIIβ Inhibits ANO1-Mediated Glioblastoma Progression. Cells. 2020 Apr 26;9(5):E1079.
Kim A, Jung HG, Kim SC, Choi M, Park JY, Lee SG, Hwang EM. Astrocytic AEG-1 regulates expression of TREK-1 under acute hypoxia. Cell Biochem Funct. 2020 Mar;38(2):167-175.
Cho CH#, Lee S#, Kim A#, Yarishkin O, Ryoo K, Lee YS, Jung HG, Yang E, Lee DY, Lee B, Kim H, Oh U, Im HI*, Hwang EM*, Park JY*. TMEM16A expression in cholinergic neurons of the medial habenula mediates anxiety-related behaviors. EMBO Rep. 2020 Feb 5;21(2):e48097.
Heo JY, Nam MH, Yoon HH, Kim J, Hwang YJ, Won W, Woo DH, Lee JA, Park HJ, Jo S, Lee MJ, Kim S, Shim JE, Jang DP, Kim KI, Huh SH, Jeong JY, Kowall NW, Lee J, Im H, Park JH, Jang BK, Park KD, Lee HJ, Shin H, Cho IJ, Hwang EM, Kim Y, Kim HY, Oh SJ, Lee SE, Paek SH, Yoon JH, Jin BK, Kweon GR, Shim I, Hwang O, Ryu H, Jeon SR, Lee CJ. Aberrant Tonic Inhibition of Dopaminergic Neuronal Activity Causes Motor Symptoms in Animal Models of Parkinson's Disease. Curr Biol. 2020 Jan 20;30(2):276-291.e9.
2019
Kim A, Jung HG, Kim YE, Kim SC, Park JY, Lee SG, Hwang EM. The Knockdown of TREK-1 in Hippocampal Neurons Attenuate Lipopolysaccharide-Induced Depressive-Like Behavior in Mice. Int J Mol Sci. 2019 Nov 24;20(23). pii: E5902.
Lee B, Hong GS, Lee SH, Kim H, Kim A, Hwang EM, Kim J, Lee MG, Yang JY, Kweon MN, Tse CM, Mark D, Oh U. Anoctamin 1/TMEM16A controls intestinal Cl- secretion induced by carbachol and cholera toxin. Exp Mol Med. 2019 Aug 5;51(8):91.
Ryu J, Kim DG, Lee YS, Bae Y, Kim A, Park N, Hwang EM*, Park JY*. Surface expression of TTYH2 is attenuated by direct interaction with β-COP. BMB Rep. 2019 Jul;52(7):445-450.
Hong GS, Lee SH, Lee B, Choi JH, Oh SJ, Jang Y, Hwang EM, Kim H, Jung J, Kim IB, Oh U. ANO1/TMEM16A regulates process maturation in radial glial cells in the developing brain. Proc Natl Acad Sci U S A. 2019 Jun 18;116(25):12494-12499.
Bae Y#, Kim A#, Cho CH, Kim D, Jung HG, Kim SS, Yoo J, Park JY and Hwang EM. TTYH1 and TTYH2 Serve as LRRC8A-Independent Volume-Regulated Anion Channels in Cancer Cells. Cells. 2019 Jun 9;8(6). pii: E562.
Park M#, Jung HG#, Kweon HJ#, Kim YE, Park JY*, Hwang EM*. The E3 ubiquitin ligase, NEDD4L (NEDD4-2) regulates bestrophin-1 (BEST1) by ubiquitin-dependent proteolysis. Biochem Biophys Res Commun. 2019 June;514(1):344-350.
Park SM, Park SH, Ryu KJ, Kim IK, Han H, Kim HJ, Kim SH, Hong KS, Kim H, Kim M, Cho BI, Heo JD, Kim NH, Hwang EM, Park JY, Yook JI, Cho HJ, Hwangbo C, Kim KD, Song H, Yoo J. Downregulation of CHIP promotes ovarian cancer metastasis by inducing Snail-mediated epithelial-mesenchymal transition. Mol Oncol. 2019 May;13(5):1280-1295.
Han YE, Kwon J, Won J, An H, Jang MW, Woo J, Lee JS, Park MG, Yoon BE, Lee SE, Hwang EM, Jung JY, Park H, Oh SJ, Lee CJ. Tweety-homolog (Ttyh) Family Encodes the Pore-forming Subunits of the Swelling-dependent Volume-regulated Anion Channel (VRACswell) in the Brain. Exp Neurobiol. 2019 Apr;28(2):183-215.
Kim DE, Cho CH, Sim KM, Kwon O, Hwang EM, Kim HW, Park JY. 14-3-3γ Haploinsufficient Mice Display Hyperactive and Stress-sensitive Behaviors. Exp Neurobiol. 2019 Feb;28(1):43-53.
2018
Choi JH, Yarishkin O, Kim E, Bae Y, Kim A, Kim SC, Ryoo K, Cho CH, Hwang EM*, Park JY*. TWIK-1/TASK-3 heterodimeric channels contribute to the neurotensin-mediated excitation of hippocampal dentate gyrus granule cells. Exp Mol Med. 2018 Nov 12;50(11):145.
Woo DH, Bae JY, Nam MH, An H, Ju YH, Won J, Choi JH, Hwang EM, Han KS, Bae YC, Lee CJ. Activation of Astrocytic μ-opioid Receptor Elicits Fast Glutamate Release Through TREK-1-Containing K2P Channel in Hippocampal Astrocytes. Front Cell Neurosci. 2018 Sep 27;12:319.
Shim HG, Jang SS, Kim SH, Hwang EM, Min JO, Kim HY, Kim YS, Ryu C, Chung G, Kim Y, Yoon BE, Kim SJ. TNF-α increases the intrinsic excitability of cerebellar Purkinje cells through elevating glutamate release in Bergmann Glia. Sci Rep. 2018 Aug 2;8(1):11589.
Lee DK, Park JY, Yoo JC, Byun EH, Bae YJ, Lee YS, Park N, Kang D, Han J, Park JY, Hwang EM, Hong SG. PTPN6 regulates the cell-surface expression of TRPM4 channels in HEK293 cells. Pflugers Arch. 2018 Jun 21.
Nam MH, Han KS, Lee J, Bae JY, An H, Park S, Oh SJ, Kim E, Hwang EM, Bae YC, Lee CJ. Expression of µ-Opioid Receptor in CA1 Hippocampal Astrocytes. Exp Neurobiol. 2018 Apr;27(2):120-128.
2017
Cho CH, Hwang EM*, Park JY*. Emerging Roles of TWIK-1 Heterodimerization in the Brain. Int J Mol Sci. 2017 Dec 24;19(1). pii: E51.
Oh SJ, Woo J, Lee YS, Cho M, Kim E, Cho NC, Park JY, Pae AN, Justin Lee C, Hwang EM. Direct interaction with 14-3-3γ promotes surface expression of Best1 channel in astrocyte. Mol Brain. 2017 Nov 9;10(1):51.
Yoo JC, Park N, Lee B, Nashed A, Lee YS, Kim TH, Lee DY, Kim A, Hwang EM, Yi GS, Park JY. 14-3-3γ regulates Copine1-mediated neuronal differentiation in HiB5 hippocampal progenitor cells. Exp Cell Res. 2017 Jul 1;356(1):85-92.
Seo JS, Lee S, Shin JY, Hwang YJ, Cho H, Yoo SK, Kim Y, Lim S, Kim YK, Hwang EM, Kim SH, Kim CH, Hyeon SJ, Yun JY, Kim J, Kim Y, Alvarez VE, Stein TD, Lee J, Kim DJ, Kim JI, Kowall NW, Ryu H, McKee AC. Transcriptome analyses of chronic traumatic encephalopathy show alterations in protein phosphatase expression associated with tauopathy. Exp Mol Med. 2017 May 19;49(5):e333.
Hwangbo C, Lee HW, Kang H, Ju H, Wiley DS, Papangeli I, Han J, Kim JD, Dunworth WP, Hu X, Lee S, El-Hely O, Sofer A, Pak B, Peterson L, Comhair S, Hwang EM, Park JY, Thomas JL, Bautch VL, Erzurum SC, Chun HJ, Jin SW. Modulation of Endothelial BMPR2 Activity by VEGFR3 in Pulmonary Arterial Hypertension. Circulation. 2017 Mar 29.
Jo M, Kim JH, Song GJ, Seo M, Hwang EM, Suk K. Astrocytic Orosomucoid-2 Modulates Microglial Activation and Neuroinflammation. J Neurosci. 2017 Mar 15;37(11):2878-2894.
2016
Ha GE, Lee J, Kwak H, Song K, Kwon J, Jung SY, Hong J, Chang GE, Hwang EM, Shin HS, Lee CJ, Cheong E. The Ca2+-activated chloride channel anoctamin-2 mediates spike-frequency adaptation and regulates sensory transmission in thalamocortical neurons. Nat Commun. 2016 Dec 19;7:13791.
Viswanath AN, Jung SY, Hwang EM, Park KD, Lim SM, Min SJ, Cho YS, Pae AN. Identification of the first in silico-designed TREK1 antagonists that block channel currents dose dependently. Chem Biol Drug Des. 2016 Dec; 88(6):807-819.
Jung JY, Lee SE, Hwang EM, Lee CJ. Neuronal expression of cell-type specific gene-silencing of BEST1 in thalamic reticular nucleus neurons using pSico-Red system. Exp Neurobiol. 2016 Jun:25(3):120-9.
Lee YS, Bae Y, Park N, Yoo JC, Cho CH, Ryoo K, Hwang EM*, Park JY*. Surface expression of the anoctamin-1(ANO1) channel is suppressed by protein-protein interactions with beta-COP. Biochem Biophys Res Commun. 2016 Jun 24; 475(2):216-22. (*Co-correspondence)
Lee YS, Lee JK, Bae Y, Lee BS, Kim E, Cho CH, Ryoo K, Yoo J, Kim CH, Yi GS, Lee SG, Lee CJ, Kang SS, Hwang EM*, Park JY*. Suppression of 14-3-3 γ –mediated surface expression of ANO1 inhibits cancer projression of glioblastoma cells. Sci Rep. 2016 May 23; 6:26413. (*Co-correspondence)
Yoon HH, Min J, Hwang EM, Lee CJ, Suh JKF, Hwang O, Jeon SR. Optogenetic inhibition of the subthalamic nucleus reduces levodopa-induced dyskinesias in a rat model of parkinson’s disease. Stereotact Funct Neurosurg. 2016; 94(1):41-53.
2015
Yarishkin O, Lee J, Jo S, Hwang EM, Lee CJ. Disinhibitory action of astrocytic GABA at the perforant path to dentate gyrus granule neuron synapse reverses to inhibitory in Alzheimer’s disease model. Exp Neurobiol. 2015 Sep; 24(3):211-8.
Cho JH, Lee YS, Kim E, Hwang EM, Park JY. Physiological functions of the TRPM4 channels via protein interactions. BMB Rep. 2015. Jan; 48(1)1-5.
2014
Oleg Y, Lee DY, Kim EJ, Cho JH, Choi JH, C. Justin Lee, Park JY, Hwang EM. TWIK-1 contributes to the intrinsic excitability of dentate granule cells in mouse hippocampus. Mol. Brain 2014. Nov 19; 7:80.
Lee DY, Kim E, Lee YS, Ryu H, Park JY, Hwang EM. The cytosolic splicing variant of NELL2 inhibits PKCbeta1 in glial cells. Biochem Biophys Res Commun 2014. Oct 29;454(3):459-464.
Park N, Yoo JC, Lee YS, Choi HY, Hong SG, Hwang EM, Park JY. Copine1 C2 domains have a critical calcium-independent role in the neuronal differentiation of hippocampal progenitor HiB5 cells. Biochem Biophys Res Commun 2014. Nov 7; 454(1):228-33.
Cho JH, Kim E, Lee YS, Yoo JC, Park JY, Hong SG, Hwang EM. Trafficking of TRPM4b on the plasma membrane mediate neuronal cell death via direct binding with 14-3-3γ. Mol. Brain 2014 Aug 21; 7(1):52.
Cho B, Cho HM, Kim HJ, Jeong J, Park SK, Hwang EM, Park JY, Kim WR, Kim HK, Sun W. CDK5-dependent inhibitory phosphorylation of Drp1 during neuronal maturation. Exp Mol Med 2014 Jul 11; 46:e105.
Jo SM, Oleg Y, Hwang YJ, Chun YE, Park M, Woo DH, Bae JY, Kim T, Lee J, Chun H, Park HJ, Lee DY, Hong J, Oh SJ, Park SJ, Lee H, Yoon BE, Jeong Y, Shin IS, Bae YC, Cho JW, Kowall N, Ryu H, Hwang EM, Kim DS, C. Justin Lee. GABA from reactive astrocytes impairs memory in Alzheimer’s diasese. Nature Medicine 2014. June 29; 20:886-96.
Kim DG, Yoo JC, Kim E, Lee YS, Yarishkin O, Lee DY, Lee KH, Hong SG, Hwang EM, Park JY. A novel cytosolic isoform of mitochondrial trans-2-enoyl-coA reductase enhances peroxisome proliferator-activated receptor alpha activity. Endocrinol Metab. 2014. June; 29(2):185-94.
Chang KY, Woo D, Jung H, Lee S, Kim S, Won J, Kyung T, Park H, Kim N, Yang HW, Park JY, Hwang EM, Kim D, Heo WD. Light-inducible receptor tyrosine kinases that regulate neurotrophin signaling. Nature Comm. 2014 June 4; 5:4057.
Paydar A, Lee B, Gangadharan G, Lee S, Hwang EM, Shin HS. Extrasynaptic GABAA receptors in mediodorsal thalamic nucleus modulate fear extinction learning. Mol. Brain 2014. May 29; 7(1):39
Yoon HH, Park JH, Kim YH, Min J, Hwang EM, Lee CJ, Francis Suh JK, Hwang O, Jeon SR. Optogenetic inactivation of the subthalamic nucleus improves forelimb akinesia in a rat model of Parkinson’s disease. Neurosurgery. 2014 May; 74(5):533-40.
Hwang EM, Kim E, Yarishkin O, Woo DH, Han KS, Park N, Bae Y, Woo J, Kim D, Park M, Lee CJ, Park JY. A disulphide-linked heterodimer of TWIK-1 and TREK-1 mediates passive conductance in astrocytes. Nature Comm. 2014 Feb 5; 5:3227.
Shin HW, Soh JS, Kim HZ, Hong J, Woo DH, Heo JY, Hwang EM, Park JY, Lee CJ. The inhibitory effects of bupivacaine, levobupivacaine, and ropivacaine on K2P (two-pore domain potassium) channel TREK-1. J Anesth. 2014 Feb; 28(1):81-6.
2013
Ha CM*, Hwang EM*, Kim E, Lee DY, Chang S, Lee BJ, Hong SG, Park JY. The molecular mechanism of NELL2 movement and secretion in hippocampal progenitor HiB5 cells. Mol Cells 2013 Dec; 36(6):527-33. (*Co-first)
Kim TW, Cho HM, Choi SY, Suguira Y, Hayasaka T, Setou M, Koh HC, Hwang EM, Park JY, Kang SJ, Kim HS, Kim H, Sun W. (ADP-ribose) polymerase 1 and AMP-activated protein kinase mediate progressive dopaminergic neuronal degeneration in a mouse model for Parkinson’s disease. Cell Death Dis. 2013 Nov 14; 4, e919.
Bae YJ, Yoo JC, Park N, Kang D, Han J, Hwang EM, Park JY, Hong SG. Acute hypoxia activates an EnaC-like channel in rat pheochromocytoma (PC12) cells. Korean J Physiol Pharmacol. 2013 Feb;17(1):57-64.
2012
Park N, Yoo JC, Ryu J, Hong SG, Hwang EM#, Park JY#. Copine1 enhances neuronal differentiation of the hippocampal progenitor HiB5 cells. Mol Cells 2012 Dec;34(6):549-54. (#Co-correspondence)
Kim YH, Park SY, Park J, Kim YS, Hwang EM, Park JY, Roh GS, Kim HJ, Kang SS, Cho GJ, Choi WS. Reduction of experimental diabetic vascular leakage and pericyte apoptosis in mice by delivery of αA-crystallin with a recombinant adenovirus. Diabetologia 2012 Oct;55(10):2835-44.
Woo DH, Han KS, Shim JW, Yoon BE, Kim E, Bae JY, Oh SJ, Hwang EM, Marmorstein AD, Bae YC, Park JY, Lee CJ. TREK-1 and Best1 Channels Mediate Fast and Slow Glutamate Release in Astrocytes upon GPCR Activation. Cell 2012 Sep 28;151(1):25-40.
Ha CM, Park D, Han JK, Jang JI, Park JY, Hwang EM, Seok H, Chang S. Calcyon forms a novel ternary complex with dopamine D1 receptor through PSD-95 and plays a role in dopamine receptor internalization. J Biol Chem. 2012 Sep 14;287(38):31813-22.
Jeong K, Kwon H, Lee J, Jang D, Hwang EM, Park JY, Pak Y. Rab6-Mediated Retrograde Transport Regulates Inner Nuclear Membrane Targeting of Caveolin-2 in Response to Insulin. Traffic 2012 Sep;13(9):1218-33.
Kim N, Yoo JC, Han JY, Hwang EM, Kim YS, Jeong EY, Sun CH, Yi GS, Roh GS, Kim HJ, Kang SS, Cho GJ, Park JY, Choi WS. Human nuclear clusterin mediates apoptosis by interacting with Bcl-XL through C-terminal coiled coil domain. J Cell Physiol. 2012 Mar;227(3):1157-67.
Lee J, Kim T, Hong J, Woo J, Min H, Hwang EM, Lee SJ, Lee CJ. Imiquimod enhances excitability of dorsal root ganglion neurons by inhibiting background (K(2P)) and voltage-gated (K(v)1.1 and K(v)1.2) potassium channels. Mol Pain 2012 Jan 11, 8(2).
2011
Jo S, Lee H, Kim S, Hwang EM, Park JY, Kang SS, Chung H. Inhibition of PCGF2 enhances granulocytic differentiation of acute promyelocytic leukemia cell line HL-60 via induction of HOXA7. Biochem Biophys Res Commun. 2011 Dec 9;416(1-2):86-91.
Baik JS, Sohn JT, Ok SH, Kim JG, Sung HJ, Park SS, Park JY, Hwang EM, Chung YK. Levobupivacaine-induced contraction of isolated rat aorta is calcium dependent. Can J Physiol Pharmacol. 2011 Jul;89(7):467-76.
Kwon H, Jeong K, Hwang EM, Park JY, Pak Y. A novel domain of caveolin-2 that controls nuclear targeting: regulation of insulin-specific ERK activation and nuclear translocation by caveolin-2. J. Cell. Mol. Med. 2011 Apr;15(4):888-908.
Ku BM, Lee YK, Ryu J, Jeong JY, Choi J, Eun KM, Shin HY, Kim DG, Hwang EM, Yoo JC, Park JY, Roh GS, Kim HJ, Cho GJ, Choi WS, Paek SH, Kang SS. CHI3L1 (YKL-40) is expressed in human gliomas and regulates the invasion, growth, and survival of glioma cells. Int. J. Cancer. 2011 Mar;128(6):1316-26.
2010
Cho HJ, Park SM, Hwang EM, Baek KE, Kim IK, Nam IK, Im MJ, Park SH, Bae S, Park JY, Yoo J. Gadd45b mediates Fas-induced apoptosis by enhancing the interaction between p38 and retinoblastoma tumor suppressor. J Biol Chem. 2010 Aug 13;285(33):25500-5.
Kim E*, Hwang EM*, Yarishkin O, Yoo JC, Kim D, Park N, Cho M, Lee YS, Sun CH, Yi GS, Yoo J, Kang D, Han J, Hong SG, Park JY. Enhancement of TREK1 channel surface expression by protein-protein interaction with beta-COP. Biochem Biophys Res Commun. 2010 Apr 30;395(2):244-50. (*Co-first)
Kang SS, Han KS, Ku BM, Lee YK, Hong J, Shin HY, Almonte AG, Woo DH, Brat DJ, Hwang EM, Yoo SH, Chung CK, Park SH, Paek SH, Roh EJ, Lee SJ, Park JY, Traynelis SF, Lee CJ. Caffeine-mediated inhibition of calcium release channel inositol 1,4,5-trisphosphate receptor subtype 3 blocks glioblastoma invasion and extends survival. Cancer Res. 2010 Feb 1;70(3):1173-83.
Choi YS, Jeong YS, Ok SH, Shin IW, Lee SH, Park JY, Hwang EM, Hah YS, Sohn JT. The Direct Effect of Levobupivacaine in Isolated Rat Aorta Involves Lipoxygenase Pathway Activation and Endothelial Nitric Oxide Release. Anesth Analg. 2010 Feb 1;110(2):341-9.
Yoo JC, Yarishkin OV, Hwang EM, Kim E, Kim DG, Park N, Hong SG, Park JY. Cloning and characterization of rat transient receptor potential-melastatin 4 (TRPM4). Biochem Biophys Res Commun. 2010 Jan 1;391(1):806–11.
Kim DG*, Hwang EM*, Yoo JC, Kim E, Park N, Rhee S, Ha CM, Hong SG, Park JY. Identification and characterization of a truncated isoform of NELL2. Biochem Biophys Res Commun. 2010 Jan 1;391(1):529–34. (*Co-first)