An insult is an expression, statement, or behavior that is often deliberately disrespectful, offensive, scornful, or derogatory towards an individual or a group. Insults can be intentional or unintentional, and they often aim to belittle, offend, or humiliate the target. While intentional insults can sometimes include factual information, they are typically presented in a pejorative manner, intended to provoke a negative emotional response or have a harmful reaction effect when used harmfully. Insults can also be made unintentionally or in a playful way but could in some cases also have negative impacts and effects even when they were not intended to insult.

In ancient Rome, political speeches and debates were known to include strong harshness and personal attacks. Historians suggest that insults and verbal attacks were common in the political discourse of the time. This practice reflected the highly confrontational nature of political engagement in ancient Rome.[1]


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In addition to political contexts, history also reveals unusual instances of insults. The Cadaver Synod, was an event where Pope Stephen VI held a posthumous trial for Pope Formosus in 897 AD. Stephen became the Pope after Pope Formosus and had his body dug up, dressed, and placed on a throne to stand trial even after his death.[5]

An example of an unintentional insult may be not tasting a dessert made by a host.[6] Comments made carelessly can also become unintentional insults. Another example could include comments made carelessly about facial features, personality traits, personal taste (e.g. in music), underestimating personal abilities or interests, asking about involvement in something potentially creating stereotypes,[7] jokes, or even walking away from someone outside are among some things that may cause offence accidentally.[8]

A backhanded (or left-handed) compliment, or asteism, is an insult that is disguised as, or accompanied by, a compliment, especially in situations where the belittling or condescension is intentional.[12]

Negging is a type of backhanded compliment used for emotional manipulation or as a seduction method. The term was coined and prescribed by pickup artists.[14] Negging is often viewed as a straightforward insult rather than as a pick-up line,[15] in spite of the fact that proponents of the technique traditionally stress it is not an insult.

Insults in poetic form is practiced through out history, more often as entertainment rather than maliciousness. Flyting is a contest consisting of the exchange of insults between two parties, often conducted in verse and became public entertainment in Scotland in the 15th and 16th centuries.[21] Senna is a form of Old Norse Eddic poetry consisting of an exchange of insults between participants.[22]

Elizabethans took great interest in such analyses, distinguishing out, for example, the "fleering frump ... when we give a mock with a scornful countenance as in some smiling sort looking aside or by drawing the lip awry, or shrinking up the nose".[26] Shakespeare humorously set up an insult-hierarchy of seven-fold "degrees. The first, the Retort Courteous; the second, the Quip Modest; the third, the Reply Churlish; the fourth, the Reproof Valiant; the fifth, the Countercheck Quarrelsome; the sixth, the Lie with Circumstance; the seventh, the Lie Direct".[27]

What qualifies as an insult is also determined both by the individual social situation and by changing social mores. Thus on one hand the insulting "obscene invitations of a man to a strange girl can be the spicy endearments of a husband to his wife".[28]

Plasticity is an intrinsic property of the central nervous system, reflecting its capacity to respond in a dynamic manner to the environment and experience via modification of neural circuitry. In the context of healthy development, plasticity is considered beneficial, facilitating adaptive change in response to environmental stimuli and enrichment, with research documenting establishment of new neural connections and modification to the mapping between neural activity and behaviour. Less is known about the impact of this plasticity in the context of the young, injured brain. This review seeks to explore plasticity processes in the context of early brain insult, taking into account historical perspectives and building on recent advances in knowledge regarding ongoing development and recovery following early brain insult, with a major emphasis on neurobehavioural domains. We were particularly interested to explore the way in which plasticity processes respond to early brain insult, the implications for functional recovery and how this literature contributes to the debate between localization of brain function and neural network models. To this end we have provided an overview of normal brain development, followed by a description of the biological mechanisms associated with the most common childhood brain insults, in order to explore an evidence base for considering the competing theoretical perspectives of early plasticity and early vulnerability. We then detail these theories and the way in which they contribute to our understanding of the consequences of early brain insult. Finally, we examine evidence that considers key factors (e.g. insult severity, age at insult, environment) that may act, either independently or synergistically, to influence recovery processes and ultimate outcome. We conclude that neither plasticity nor vulnerability theories are able to explain the range of functional outcomes from early brain insult. Rather, they represent extremes along a 'recovery continuum'. Where a child's outcome falls along this continuum depends on injury factors (severity, nature, age) and environmental influences (family, sociodemographic factors, interventions).

But what's hard to demonstrate to the ABIM is that [this learning] is already happening. I think we can do it if we submit our records of CME credits that we formally accrue. The reason this is such an almost insult to oncologists in practice is because it is a necessary part of our day-to-day existence to keep apprised of developments so we can apply them to patient care.

Moreover, in the case of mental illness-related insults, it perpetuates a cruel stigma, hurting millions of people who suffer from mental illnesses. The stigma is also a barrier to help-seeking for people in need.

Lebanese authorities and powerful individuals, including political, judicial, religious and security figures, are weaponizing the criminal insult, slander and libel laws to harass, intimidate and silence people who criticize them or try to expose their misconduct or alleged corruption. These problematic provisions in the Penal Code, Publications Law, and the Military Code of Justice, which carry sentences of up to three years in prison, fail to meet international standards and unduly restrict the right to freedom of expression.

Plasmodium falciparum infections can cause severe malaria, but not every infected person develops life-threatening complications. In particular, carriers of the structural haemoglobinopathies S and C and infants are protected from severe disease. Protection is associated with impaired parasite-induced host actin reorganization, required for vesicular trafficking of parasite-encoded adhesins, and reduced cytoadherence of parasitized erythrocytes in the microvasculature. Here we show that aberrant host actin remodelling and the ensuing reduced cytoadherence result from a redox imbalance inherent to haemoglobinopathic and fetal erythrocytes. We further show that a transient oxidative insult to wild-type erythrocytes before infection with P. falciparum induces the phenotypic features associated with the protective trait of haemoglobinopathic and fetal erythrocytes. Moreover, pretreatment of mice with the pro-oxidative nutritional supplement menadione mitigate the development of experimental cerebral malaria. Our results identify redox imbalance as a causative principle of protection from severe malaria, which might inspire host-directed intervention strategies.

How to cite this article: Cyrklaff, M. et al. Oxidative insult can induce malaria-protective trait of sickle and fetal erythrocytes. Nat. Commun. 7, 13401 doi: 10.1038/ncomms13401 (2016).

R. What are coma and persistent vegetative state, and how do we evaluate them under 11.20? Coma is a state of unconsciousness in which a person does not exhibit a sleep/wake cycle, and is unable to perceive or respond to external stimuli. People who do not fully emerge from coma may progress into a persistent vegetative state (PVS). PVS is a condition of partial arousal in which a person may have a low level of consciousness but is still unable to react to external stimuli. In contrast to coma, a person in a PVS retains sleep/wake cycles and may exhibit some key lower brain functions, such as spontaneous movement, opening and moving eyes, and grimacing. Coma or PVS may result from TBI, a nontraumatic insult to the brain (such as a vascular insult, infection, or brain tumor), or a neurodegenerative or metabolic disorder. Medically induced comas are not considered under 11.20 and should be considered under the section pertaining to the underlying reason the coma was medically induced and not under this section.

B. Disorganization of motor function in two extremities (see 11.00D1), resulting in an extreme limitation (see 11.00D2) in the ability to stand up from a seated position, balance while standing or walking, or use the upper extremities, persisting for at least 3 consecutive months after the insult.

While Rushdie's First Amendment freedoms are important, we have tended to promote him and his book with little acknowledgment that it is a direct insult to those millions of Moslems whose sacred beliefs have been violated and are suffering in restrained silence the added embarrassment of the Ayatollah's irresponsibility.

This is the kind of intercultural wound that is difficult to heal. Western leaders should make it clear that in protecting Rushdie's life and civil rights, there is no endorsement of an insult to the sacred beliefs of our Moslem friends. e24fc04721

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