The major factors driving the internationalization of business include: market opportunities in new regions, increased global competition, reduced trade barriers due to globalization, technological advancements enabling easier cross-border communication, cost advantages from operating in different locations, and government policies promoting international trade.

Alternative strategies for developing global businesses include: market research, standardization strategy, multidomestic strategy, transnational strategy, strategic alliances, franchising, joint ventures, exporting, licensing, adapting marketing strategies to local cultures, building local partnerships, supply chain management, and considering entry mode strategies depending on the specific market and business needs.

Global information systems present challenges like cultural differences, language barriers, varying legal regulations, disparate local systems, data quality issues, and cybersecurity concerns.

When developing international information systems, key issues to consider include: differing time zones, language barriers, cultural variations, data privacy regulations, currency fluctuations, network infrastructure disparities, and varying levels of technological adoption across regions; while technical alternatives to address these challenges include: standardized data formats, multilingual interfaces, localized content delivery, cloud-based systems, data encryption, distributed databases, and robust network architectures with redundancy features.