after the first dose (12). The other study reported that vaccine efficacy of the mRNA-1273 vaccine 14 days after the second dose was difficult to assess because of the low incidence of laboratory-confirmed COVID-19 in the trial population (4 cases in the placebo group and 0 cases in the mRNA-1273 group) (13). Of note, the geometric mean ratio of neutralizing antibodies in adolescents receiving those vaccines was similar to or greater than that of young adults after receipt of 2 doses (12,13). Behavioral and testing policy factors can potentially affect estimations of vaccine effectiveness. Behaviors that increase exposure to SARS-CoV-2 may be assumed by vaccinated or unvaccinated adolescents for different reasons and are difficult to measure. During the study period, SARS-CoV-2 testing was available in Israel regardless of vaccination status. The recent rise in SARS-CoV-2 cases in Israel raised 2 concerns. The first concern was that BNT162b2 vaccine–elicited immunity was waning. Waning of spike protein antibody levels was detected over time after receipt of a second dose of SARS-CoV-2 vaccines (14). The second concern was that the vaccine was not effective against the SARS-CoV-2 Delta variant. However, our findings indicate that the BNT162b2 vaccine provides adolescents with highly effective short-term protection against the SARS-CoV-2 Delta variant. Dr. Glatman-Freedman is the director of the Infectious Diseases Unit in the Israel Center for Disease Control. She is affiliated academically with the School of Public Health at Tel Aviv University. Her primary research interests are the epidemiology of respiratory viruses, syndromic surveillance, and vaccine effectiveness. Acknowledgment A.G.-F. conceived and designed the study, led data analysis, and wrote the first draft of the manuscript. M.B. oversaw the study design and analysis. Y.H. and R.D. retrieved the data. Y.H. and R.D. performed data analysis. Z.K. performed comparative evaluation with previous data. A.G.-F., Z.K., L.K.-B., and M.B. interpreted the data and edited the final manuscript. All authors revised the manuscript critically for important intellectual content and approved the final version of the manuscript. Abstract Multidrug resistance is a major threat to global elimination of tuberculosis (TB). We performed phenotypic drug-susceptibility testing and whole-genome sequencing for 309 isolates from 342 consecutive patients who were given a diagnosis of TB in Yangon, Myanmar, during July 2016‒June 2018. We identified isolates by using the GeneXpert platform to evaluate drug-resistance profiles. A total of 191 (62%) of 309 isolates had rifampin resistance; 168 (88%) of these rifampin-resistant isolates were not genomically related, indicating the repeated emergence of resistance in the population, rather than extensive local transmission. We did not detect resistance mutations to new oral drugs, including bedaquiline and pretomanid. The current GeneXpert MTB/RIF system needs to be modified by using the newly launched Xpert MTB/XDR cartridge or line-probe assay. Introducing new oral drugs to replace those currently used in treatment regimens for multidrug-resistant TB will also be useful for treating TB in Myanmar. Tuberculosis (TB) is the infectious disease that causes the most deaths worldwide (≈5,000/day) (1). Of major concern is the increasing prevalence of drug resistance worldwide (1). There are different forms of TB drug resistance: pre‒multidrug-resistant TB (pre‒MDR TB, resistant to 1 of 2 first-line drugs: