Research

Our mission

We are developing a new nanotechnology for biomedical and bioengineering applications. Last few decades, nanomaterials have been developed their own excellent physical, chemical, and photophysical properties. These properties allow the nanomaterials to be applied in various preclinical and clinical approaches. To fully utilize the nanomaterials as a powerful tool in biomedical applications, we need to understand better the interaction between nanomaterials and biological systems and design their interface to be sensitive and/or unresponsive. We focused on how we can make a bridge to apply the nanotechnology in clinical approaches. Functional groups, size, shape, surface charges, and composition of core nanomaterials should be individually and precisely tailored for the certain purpose in biomedical applications. Unique physical, chemical, and biological properties of a next-generation of nanomedicine and nanomaterials should be investigated.

Nanomedicine

ref. https://drinkhrw.com/blog/, Park et al., ACS Nano, 2015, 9, 6511-6521

Nanomedicine is a nanotechnology that have been applied in biomedical applications, biological nanosensors, contrast agents, and theragnosis probes. Biological stimuli sensitive nanomedicine can be achieved by tailoring their surface chemistry, size, circulation time in vivo, and compositions. Nanomaterial-doped implantable devices can be an alternative diagnostic tool for many diseases.

Nanomaterials

ref. Park et al., Nat Commun., 2020, 5748

Unique physical and chemical properties of nanomaterials allow us to utilize them as a novel theragnostic tool in biomedical applications. Photophysical properties of metal and metal chalcogenides nanomaterials have been extensively investigated for last decades. Magnetic properties of metal oxide nanoparticles also have been delicately optimized. We focus on how these properties of nanomaterials can translate and interpret the biological phenomena, such as intracellular signaling, membrane potential propagation, hypoxia, inflammatory environments, necrosis, and transient emission of reactive oxygen and nitrogen species.

Nano-Bio Interface

Ref. Park et al., ACS Nano, 2013, 7, 9416-9427

Studying the interaction between nanomaterials and biological systems are very important to properly interpret and amplify the biological signals. Surface functionalization of nanoparticles should be further improved for enhancing sensitivity and minimizing the false-positive signals. We develop a next-generation theragnostic methodology by studying various composition of nanomaterials, biological stimuli sensitive nanomaterials, photophysical phenomena of nanomaterials, and integrated nanobiomaterials for genomics and proteomics.

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