Research Interests

The human immune system varies widely across individuals and populations, shaped by genetic background, age, sex, environment, and immune exposure. We investigate how immune-cell composition, functional states, and T- and B-cell receptor repertoires differ between people, with the aim of defining the biological diversity underlying immune responses, disease susceptibility, and treatment outcomes. 

Immune-mediated diseases are not defined by a single uniform immune response. Patients with the same diagnosis may show distinct immune-cell profile, activation states, and receptor repertoires, while different diseases may share common inflammatory pathways. We investigate immune heterogeneity both within and across diseases to identify shared mechanisms, disease-specific features, and biologically meaningful patient subgroups. 

Neuroinflammation arises through diverse immune mechanisms across autoimmune, infectious, and neurodegenerative diseases. We investigate immune cells and molecular programs in paired cerebrospinal fluid and peripheral blood to understand how systemic immunity relates to compartment-specific responses within the central nervous system. By comparing shared and distinct patterns across diseases, we aim to identify mechanisms of intrathecal inflammation, immune-cell trafficking, and auto-antigen detection.