Immunology Yoo Lab
Immunology Yoo Lab
- Immune Mechanisms in Disease
The Immunology Lab of Dr. Yoo focuses on investigating the pathophysiology of autoimmune diseases at the molecular and cellular levels, with the aim of identifying novel therapeutic targets.
Our research places particular emphasis on rheumatoid arthritis, investigating the pathological activation of synoviocytes and their interactions with immune cells. We explore how growth factors, transcription factors, and immunoregulatory proteins contribute to inflammation and tissue destruction.
In recent years, we have also been actively studying the impact of microplastics on the immune system, employing diverse animal models to replicate disease-relevant conditions and better understand immune dysfunction in vivo.
Our goal is to advance the understanding of immune-mediated diseases and to contribute to the development of new therapeutic strategies, while also conducting leading research to uncover the connections between environmental factors and immune regulation.
๐๏ธKey Publicationsย
Placental growth factor regulates the generation of TH 17 cells
to link angiogenesis with autoimmunity
nature immunology (2019)
Role of high-temperature requirement serine protease A 2
in rheumatoid inflammation
arthritis research & therapy (2023)
ย โCore Experimental Techniquesย
Primary cell / Cell line culture
animal model
molecular and immunological techniques (e.g., qRT-PCR, Western blot, ELISA)ย
ย