Publications

Selected publications

Visit Google Scholar for Dr. June-Yong Lee's complete publication record.
(* co-first, # co-correspondence)

2023

• Meyer J. Friedman, Haram Lee, June-Yong Lee# and Soohwan Oh#. Transcriptional and Epigenetic Regulation of Context-Dependent Plasticity in T-Helper Lineages. Immune Network. Feb 23;23(1):e5. 2023. Read Paper

2022

• Jason A Hall, Maria Pokrovskii, Lina Kroehling, Bo-Ram Kim, Seung Yong Kim, Lin Wu, June-Yong Lee# and Dan R Littman#. Transcription factor RORα enforces stability of the Th17 cell effector program by binding to a Rorc cis-regulatory element. Immunity. Nov 8;55(11):2027-2043.e9, 2022. Read Paper

• Begum Akuzum and June-Yong Lee. Context-Dependent Regulation of Type17 Immunity by Microbiota at the Intestinal Barrier. Immune Network. Oct;22(5):e46, 2022. Read Paper

• Juli Choi*, Bo-Ram Kim*, Begum Akuzum*, Leechung Chang*, June-Yong Lee# and Ho-Keun Kwon#. TREGking from Gut to brain: the control of regulatory T cells along the Gut-Brain axis. Frontiers in immunology. Jun 30; 13:916066, 2022. Read Paper

• Gi Uk Jeong, Jaemyun Lyu, Kyun-Do Kim, Young Cheul Chung, Gun Young Yoon, Sumin Lee, Insu Hwang, Won-Ho Shin, Junsu Ko, June-Yong Lee and Young-Chan Kwon. SARS-CoV-2 Infection of Microglia Elicits Proinflammatory Activation and Apoptotic Cell Death. Microbiology Spectrum. May 5;10(3):e01091-22, 2022. Read Paper

2021

• Martyna Okuniewska, Victoria Fang, Audrey Baeyens, Varsha Raghavan, June-Yong Lee, Dan R. Littman and Susan R. Schwab. SPNS2 enables Tcell egress from lymph nodes during an immune response. Cell Reports. July 13; 36(2):109368, 2021. Read Paper

2020

• June-Yong Lee*, Jason A. Hall*, Maria Pokrovskii*, Lina Kroehling, Lin Wu and Dan R. Littman.  RORα enforces stability of the T-helper-17 cell effector program. Submitted. Deposited in bioRxiv. Read Paper

• June-Yong Lee*, Jason A. Hall*, Lina Kroehling, Woan-Yu Lin, Stephen T. Yeung, Henry Nguyen, Lin Wu, Hernandez Moura Silva, Tariq Najar, Dayi Li, Ashley Hine, P’ng Loke, Jerome C. Martin, Ephraim Kenigsberg, Miriam Merad, Kamal M. Khanna and Dan R. Littman. Serum amyloid A proteins induce pathogenic Th17 cells and promote inflammatory disease. Cell. Jan 9;180(1):79-91, 2020. Read paper

2019

• Emily R. Miraldi, Maria Pokrovskii, Aaron Watters, Dayanne M. Castro, Nicholas De Veaux, Jason A. Hall, June-Yong Lee, Maria Ciofani, Aviv Madar, Nick Carriero, Dan R. Littman and Richard Bonneau. Leveraging chromatin accessibility for transcriptional regulatory network inference in T Helper 17 Cells. Genome Res. Mar 29(3):449-463, 2019. Read paper

2017

• Lung Cheung, Fan Zhang, Anbalagan Jaganathan, Rajal Sharma, Qiang Zhang, Tsuyoshi Konuma, Tong Shen, June-Yong Lee, Chunyan Ren, Chih-Hung Chen, Geming Lu, Weijia Zhang, Mark H. Kaplan, Dan R. Littman, Martin J. Walsh, Huabao Xiong, Lei Zeng and Ming-Ming Zhou. Distinct Roles of Brd2 and Brd4 in Potentiating the Transcriptional Program for Th17 Cell Differentiation. Mol Cell. Mar 16;65(6):1068-1080, 2017.  Read paper

2016

• Kristin R. Renkema, June-Yong Lee, You Jeong Lee, Sara E. Hamilton, Kristin A. Hogquist and Stephen C. Jameson. IL-4 sensitivity shapes the peripheral CD8+ T cell pool and response to infection. J Exp Med. Jun 27;213(7):1319-29, 2016. Read paper

2015

• Teruyuki Sano, Wendy Huang, Jason A. Hall, Yi Yang, Alessandra Chen, Samuel J. Gavzy, June-Yong Lee, Joshua W. Ziel, Emily R. Miraldi, Ana I. Domingos, Richard Bonneau and Dan R. Littman. An IL-23R/IL-22 Circuit Regulates Epithelial Serum Amyloid A to Promote Local Effector Th17 Responses. Cell. Oct 8;163(2):381-93, 2015. Read paper

• June-Yong Lee, Cara N. Skon, You Jeong Lee, Soohwan Oh, Justin J. Taylor, Deepali Malhotra, Marc K. Jenkins, M. Geoffrey Rosenfeld, Kristin A. Hogquist and Stephen C. Jameson. KLF2 restrains follicular helper CD4+ T cell differentiation. Immunity. Feb 17;42(2):252-64, 2015. Read paper

2013

• Cara N. Skon, June-Yong Lee, Kristin G. Anderson, David Masopust, Kristin A. Hogquist and Stephen C. Jameson. Transcriptional downregulation of S1PR1 is required for establishment of resident memory CD8+ T cells. Nat Immunol. Dec;14(12):1285-93, 2013. Read paper

• June-Yong Lee, Sara E. Hamilton, Adovi D. Akue, Kristin A. Hogquist and Stephen C. Jameson. Virtual memory CD8 T cells display unique functional properties. PNAS. Aug 13;110 (33):13498-503, 2013. Read paper

2012

• Sun Hwa Lee, Zsolt Toth, Lai-Yee Wong, Kevin Brulois, Jim Nguyen, June-Yong Lee, Ebrahim Zandi and Jae U. Jung. Novel Phosphorylations of IKKγ/NEMO. MBio. Nov 6;3(6):e00411-12, 2012. Read paper

• Zhen Zhao, Soohwan Oh, Dapeng Li, Duojiao Ni, Sara Dolatshahi Pirooz, Joo-Hyung Lee, Shunhua Yang, June-Yong Lee, Irene Ghozalli, Vincenzo Costanzo, Jeremy M. Stark and Chengyu Liang. A Dual Role for UVRAG in Maintaining Chromosomal Stability Independent of Autophagy. Dev Cell. May 15;22(5):1001-16, 2012. Read paper

• Chul-Su Yang, Jong-Soo Lee, Chan-Ki Min, June-Yong Lee, Hee Jin Kim, Kwanghoon Lee, Byungha Oh, Chul-Joong Kim, Ebrahim Zandi, Zhenyu Yue, Joseph H. Jeong, Chengyu Liang and Jae U Jung. Autophagy protein Rubicon mediates phagocytic NADPH oxidase activation in response to microbial infection or TLR stimulation. Cell Host Microbe. Mar 15;11(3):264-76, 2012. Read paper

• Chul-Su Yang, Chan-Ki Min, Mary Rodgers, Jong-Soo Lee, Lara Kingeter, June-Yong Lee, Ambrose Jong, Xin Lin and Jae U Jung. The autophagy regulator Rubicon is a feedback inhibitor of CARD9-mediated host innate immunity. Cell Host Microbe. Mar 15;11(3):277-89, 2012. Read paper

• Adovi D. Akue, June-Yong Lee and Stephen C. Jameson. Derivation and maintenance of virtual memory CD8 T cells. Journal of Immunology. Mar 15;188(6):2516-23, 2012. Read paper

• June-Yong Lee and Stephen C. Jameson. Remembering to be tolerant (Perspective). Science. Feb 10;335(6069):667-8, 2012. Read paper

2011

• Soohwan Oh, Xiaofei E, Duojiao Ni, Sara Dolatshahi Pirooz, June-Yong Lee, Dongwook Lee, Zhen Zhao, Stacy Lee, HyeraLee, Bonsu Ku, Timothy Kowalik, Sue E.Martin, Byung-Ha Oh, Jae U Jung and Chengyu Liang. Downregulation of Autophagy by Bcl-2 Promotes MCF7 Breast Cancer Cell Growth Independent of Its Inhibition of Apoptosis. Cell death & Differentiation. Mar;18(3):452-64. 2011. Read paper

2010

• Jaehyuk Yoo, Jinjoo Kang, Ha Neul Lee, Berenice Aguilar, Darren Kafka, Sunju Lee, Inho Choi, Juneyong Lee, Swapnika Ramu, Juergen Haas, Chester J. Koh, Young-Kwon Hong. Kaposin-B enhances the PROX1 mRNA stability during lymphatic reprogramming of vascular endothelial cells by Kaposi's sarcoma herpes virus. PLoS Pathog. Aug 12;6(8). 2010. Read paper

2009

• Jong-Soo Lee, Qinglin Li, June-Yong Lee, Sun-Hwa Lee, Joseph H. Jeong, Hye-Ra Lee, Heesoon Chang, Fu-Chun Zhou, Shou-Jiang Gao, Chengyu Liang and Jae U. Jung. FLIP-mediated autophagy regulation in cell death control. Nature Cell Biol. 11(11):1355-62. 2009. Read paper

• Sunju Lee, Jinjoo Kang, Jaehyuk Yoo, Sathish K. Ganesan, Sarah C. Cook, Berenice Aguilar, Swapnika Ramu, Juneyong Lee and Young-Kwon Hong.  Prox1 physically and functionally interacts with COUP-TFII to specify lymphatic endothelial cell fate. Blood. 113 (8): 1856-1859. 2009. Read paper

2008

• Seung-Ki Kwok*, June-Yong Lee*, Se-Ho Park, Mi-La Cho, So-Youn Min, Sung-Hwan Park, Ho-Youn Kim and Young-Gyu Cho. Dysfunctional interferon-alpha production by peripheral plasmacytoid dendritic cells upon Toll-like receptor-9 stimulation in patients with systemic lupus erythematosus. Arthritis Res Ther. 10(2):R29. 2008. Read paper

• June-Yong Lee, Yu-Mi Lim, Min-Jung Park, So-Youn Min, Mi-La Cho, Young-Chul Sung, Se-Ho Park, Ho-Youn Kim and Young-Gyu Cho. Murine thymic stromal lymphopoietin promotes the differentiation of regulatory T cells from thymic CD4(+)CD8(-)CD25(-) naïve cells in a dendritic cell-independent manner. Immunol Cell Biol. 86(2):206. 2008. Read paper