Peer-Reviewed

2025

Isoxazole-based molecules restore NK cell immune surveillance in hepatocarcinogenesis by targeting TM4SF5 and SLAMF7 linkage

JE Kim†, HS Kim†, W Kim†, EH Lee, S Kim, T Kim, E-A Shin, K-h Pyo, H Lee, SH Jin, J-H Lee, S-M Byeon, DJ Kim, SJ Yu, S Kim, JY Yoo, S-C Lee, Y-G Suh*, JW Lee*. (Co-first author, IF = 52.7)

Signal Transduction & Targeted Therapy. 2025. 10(1):15. 

PMID: 39828766

Hepatocyte TM4SF5 stabilizes cytosolic NCOA3 and supports macropinocytosis for albumin uptake and bioenergetics during hepatocellular carcinoma progression

HS Lee, JE Kim, E-A Shin, YD Pinanga, K-h Pyo, EH Lee, W Kim, S Kim, JW Lee. 

Experimental & Molecular Medicine, 2025. 57(4):836-855.

PMID: 40186033

2024

Mitochondria reprogramming by cholesterol export at TM4SF5-enriched mitochondrialysosome contact sites

JE Kim, S-Y Park, C Kwak, Y Lee, D-G Song, JW Jung, H Lee, E-A Shin, Y Pinanga, Kh Pyo, EH Lee, W Kim, S-Y Kim, C-D Jun, S Choi, H-W Rhee, K Liu*, JW Lee*. (First author, IF = 24.9)

Cancer Communications. 2024. 44: 47-75.

PMID: 38133457

Association between hepatocyte TM4SF5 expression and gut microbiome dysbiosis during non-alcoholic fatty liver disease development

YD Pinanga#, K-h Pyo#, E-A Shin, H Lee, EH Lee, W Kim, S Kim, JE Kim, S Kim, JW Lee

Life Sciences. 2024. 358: 123164. 

PMID: 39454995

2023

Differential ligand binding/trafficking for distinct CTLA-4 fates; Is an expandable mechanism?

JE Kim*, E Kim*, JW Lee. (Co-first author, IF = 22.096)

Cellular & Molecular Immunology. 2023. 20(1):1-2. 

PMID: 36357521.

TM4SF5-mediated abnormal food-intake behavior and apelin expression facilitate non-alcoholic fatty liver disease features

YD Pinanga, HA Lee, E-A Shin, H Lee, K-H Pyo, JE Kim, EH Lee, W Kim, S Kim, HY Kim, JW Lee.

iScience, 2023. 26(9):107625.

PMID: 37670786

2022

Liver-originated small extracellular vesicles with TM4SF5 target brown adipose tissue for homeostatic glucose clearance

JW Jung*, JE Kim*, E Kim*, H Lee, H Lee, E-A Shin, JW Lee. (Co-first author, IF = 14.5)

Journal of Extracellular Vesicles. 2022. 11(9):12262.

PMID: 36063136

Crosstalk between TM4SF5 and GLUT8 regulates fructose metabolism in hepatic steatosis

HJ Lee*, E Kim*, E-A Shin*, JC Shon, HS Sun, JE Kim, JW Jung, H Lee, Y Pinanga, DG Song, K-H Liu, JW Lee.

Molecular Metabolism. 2022. 58:101451.

PMID: 35123128

TM4SF5-mediated regulation of hepatocyte transporters during metabolic liver diseases

JE Kim*, E Kim*, JW Lee. (Co-first author, IF = 5.7)

International Journal of Molecular Sciences. 2022. 23: 8387.

PMID: 35955521

2021

N-terminus-independent activation of c-Src via binding to a tetraspan(in) TM4SF5 in hepatocellular carcinoma is abolished by the TM4SF5 C-terminal peptide application

HE Song*, Y Lee*, E Kim*, CY Cho, O Jung, D Lee, EG Lee, SH Nam, M Kang, S JY Macalino, JE Kim, JW Jung, SW Kwon, S Choi, Lee JW.

Theranostics. 2021. 11(16):8092-8111.

PMID: 34335982

TM4SF5-dependent crosstalk between hepatocytes and macrophages to reprogram the inflammatory environment

E Kim*, H Um*, J Park*, JW Jung, JE Kim, H Lee, E-A Shin, Y Pinanga, H Lee, SH Nam, Lee JW.

Cell Reports. 2021. 37(7):110018

PMID: 34788612

2020

Amino acid transporters as tetraspanins TM4SF5 binding partners

Jung JW*, Kim JE*, Kim EM*, Lee JW. (Co-first author, IF = 12.9)

Exp Mol Med. 2020. Jan;52(1):7-14

PMID: 31956272

2019

TM4SF5-mediated CD44v8-10 splicing variant promotes survival of type II alveolar epithelial cells during idiopathic pulmonary fibrosis

JE Kim, H-J Kim, JW Jung, D-G Song, D Park, H Lee, H Um, J Park, SH Nam, M Cho, Lee JW. (First author, IF = 9.6)

Cell Death & Disease. 2019. 10(9):645.

PMID:31501417

Transmembrane 4 L Six Family Member 5 Senses Arginine for mTORC1 Signaling

Jung JW, Macalino SJY, Cui MH, Kim JE, Kim HJ, Song DG, Nam SH, Kim S, Choi S, Lee JW.

Cell Metabolism. 2019 Jun 4;29(6):1306-1319.e7.

PMID: 30956113

Glutamyl-prolyl-tRNA synthetase induces fibrotic extracellular matrix via both transcriptional and translational mechanisms

Song DG, Kim D, Jung JW, Nam SH, Kim JE, Kim HJ, Kim JH, Lee SJ, Pan CH, Kim S, Lee JW

FASEB J. 2019 Mar;33(3):4341-4354.

PMID: 30592630

2018

Lysyl-tRNA synthetase-expressing colon spheroids induce M2 macrophage polarization to promote metastasis

Nam SH, Kim D, Lee D, Lee HM, Song DG, Jung JW, Kim JE, Kim HJ, Kwon NH, Jo EK, Kim S, Lee JW.

J Clin Invest. 2018 Nov 1;128(11):5034-5055.

PMID: 30188867

 Preprinted

2024

Direct mitochondrial import of lactate supports resilient carbohydrate oxidation

AA Cluntun, JR Visker, JN Velasco-Silva, MJ Lang, L Cedeno-Rosario, TS Shankar, R Hamouche, J Ling, JE Kim, AG Toshniwal, HK Low, CN Cunningham, J Carrington, JL Catrow, Q Pearce, M-Y Jeoung, AJ Bott, AJ Narbona-Perez, CE Stanley, Q Li, DR Eberhardt, JT Morgan, T Yadav, CE Wells, DKA Ramadurai, WI Swiatek, D Chaudhuri, JD Rothstein, DM Muoio, JA Paulo, SP Gygi, SA Baker, S Navankasattusas, JE Cox, K Funai, SG Drakos, J Rutter, GS Ducker.

bioRxiv, 2024.10.07.617073