Light microscopy
1st prize:
"Oxygen molecules play a game of Catan"
Daan Weits
(UU)
Microscope: Apotome Zeiss
Expression of an oxygen biosensor in a gemma of Marchantia polymorpha, an ancient liverwort species that is a model plant for evolution. The output of the oxygen biosensor is red fluorescence (false color blue) in the presence of oxygen and green fluorescence in hypoxic cells..
2nd prize:
"The Visitor"
Alessandro Corsini
(Hubrecht)
Microscope: Nikon/Andor X1 spinning disk microscope, 30X objective.
A mouse small intestinal organoid that experienced cell division mis-orientation during its growth. Blue is DNA, red is actin, and green is tubulin. During their normal growth, these organoids are rounded and have a well-organized layer of cells surrounding a lumen. Cells maintain this structure by dividing all in the same direction. However, when the orientation of cell division is altered, cells start to aggregate in multiple layers and form multiple lumens, mimicking a tumorigenic process. Organoids now look completely different. In this case, the face of ''a visitor from beyond the stars''..