Hyperpolarized Carbon-13 MRI

What is Hyperpolarized (HP) imaging?

New medical imaging technique for probing metabolism and perfusion using injected substrates
It utilizes dynamic nuclear polarization techniques for dramatic enhancement of the polarization of carbon-13 containing molecules
It allows a real-time monitoring of metabolic activity in living systems

Relevance of HP C-13 MRI

Malignant cells frequently have up-regulated lactate dehydrogenase A (LDHA), which is an enzyme that regulates pyruvate-to-lactate reaction
HP C-13 MRI has potentials for monitoring tumor growth and assessing response to therapy in cancer

Pyruvate metabolism

Polarization of [1-13C]pyruvate and subsequent injection can be used to monitor its distribution and conversions to lactate, alanine and bicarbonate in living systems

Investigating the Feasibility of In Vivo Perfusion Imaging Methods for Spinal Cord Using Hyperpolarized [13C]t-Butanol and [13C,15N2]Urea

(Lee SJ, et al. Mol Imaging Biol. 2022)

Differentiating Radiation Necrosis from Brain Tumor Using Hyperpolarized Carbon-13 MR Metabolic Imaging

(Park I, et al. Mol Imaging Biol. 2021)

Application of HP C-13 MRI in pre-clinical models

(Park I, et al. Cancer Res. 2014)

Example of a control and a treated glioma-bearing rat, showing its T1 post-gadolinium images, 13C spectra zoomed-in around brain and the ratio of lactate to pyruvate (Lac/Pyr) overlay map at baseline, one day and two days after chemotherapy. In the control group, the lactate peak continued to increase relative to the pyruvate peak after the treatment, resulting in a steep increase in Lac/Pyr. In contrast, the lactate peak decreased shortly after the treatment in the treated group, resulting in a drastic drop in Lac/Pyr

Application of HP C-13 MRI in clinical study

(Park I, et al. Magn Reson Med. 2018)

Color overlays of the ratio of lactate to pyruvate (lac/pyr) and bicarbonate to pyruvate (bicarb/pyr) maps interpolated and superimposed on post-gadolinium T1-weighted images and arrays of summed spectra from a patient with glioblastoma that was progressing. The bicarb/pyr was visible in regions of normal appearing brain but was not detected in the T2 lesion

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