SCI/E papers

Google Scholar 

• V.T.D. Phuc, M.G. Kang, H. Kim, Y.K. Ko, S. Acharya,  E.B. Kim, J.Y. Park, S.H. Chang, H.J. Kim, H.J. Yoon,  and Y. Choi. Induction of Oral Lichen Planus–like Histopathology in Mice. Journal of Dental Research. 2025, Vol. 104(3) 320 –329. [link]

• Youngnim Choi. Animal models to study the pathogenesis and novel therapeutics of oral lichen planus. Front Oral Health. 2024 May 9:5:1405245 [link]

• Belibasakis GN, Senevirantne CJ, Jayasinghe RD, Vo PT, Bostanci N, Choi Y. Bacteriome and mycobiome dysbiosis in oral mucosal dysplasia and oral cancer. Periodontol 2000. 2024 [link] 

• Choi Y. Association of Neutrophil Defects with Oral Ulcers but Undetermined Role of Neutrophils in Recurrent Aphthous Stomatitis. Heliyon 2024:e26740. [link]  

• Ko YK, Kim E, Lee EJ, Nam SJ, Kim Y, Kim S, Choi SY, Kim HY, Choi Y. Enrichment of infection-associated bacteria in the low biomass brain bacteriota of Alzheimer's disease patients. PLoS One. 2024;19(2):e0296307. [link] 

• Kim HY, Lim Y, Jang JS, Ko YK, Choi Y, Kim HH, Choi BK. Extracellular vesicles from periodontal pathogens regulate hepatic steatosis via Toll-like receptor 2 and plasminogen activator inhibitor-1. J Extracell Vesicles. 2024;13(1):e12407. [link] 

• Hong J, Park HK, Chang SH, Byun JM, Shin DY, Koh Y, Yoon SS, Choi Y, Kim I. A randomized phase II study of acyclovir for the prevention of chemotherapy-induced oral mucositis in patients undergoing autologous hematopoietic stem cell transplantation. BMC Oral Health. 2023;23:1008. [link] 

• Acharya S, Lee A, Kim H, Kim HJ, Choi Y. Requirements for anti-aquaporin 5 autoantibody production in a mouse model. Mol Oral Microbiol. 2023;38:442-453. [link] 

• Chang S-H, Choi Y. Gut dysbiosis in autoimmune diseases: Association with mortality. Front Cell Infect Microbiol. 2023;13:1157918. [link] 

• Chang S-H, Park S-H, Cho M-L, Choi Y. Why Should We Consider Potential Roles of Oral Bacteria in the Pathogenesis of Sjögren Syndrome? Immune Netw. 2022;22:e32. [link]

• Ko YK, Hong S, Kim HM, Liu M, Moon E, Kim P, Choi Y. Characterization of junctional structures in the gingival epithelium as barriers against bacterial invasion. J Periodontal Res. 2022 Aug;57(4):799-810. [link]

• Liu M, Choi Y. A murine periodontitis model using coaggregation between human pathogens and a dominant mouse oral commensal. J Periodontal Implant. Sci. 2022 Apr;52(2):141-154. [link]

• Lee A, Yoo DK, Lee Y, Jeon S, Jung S, Noh J, Ju S, Hwang S, Kim HH, Kwon S, Chung J, Choi Y. Induction of anti-aquaporin 5 autoantibody production by immunization with a peptide derived from the aquaporin of Prevotella melaninogenica leads to reduced salivary flow in mice. Immune Netw. 2021;21:e34. [link] 

• Vo PT, Choi SS, Park HR, Lee A, Jeong SH, Choi Y. Gene signatures associated with barrier dysfunction and infection in oral lichen planus identified by analysis of transcriptomic data. PLoS One. 16:e0257356, 2021. [link]

• Yoo YJ, Pernpanayagam H, Choi Y, Gu Y, Chang SW, Baek SH, Zhu Q, Fouad AF, Kum KY. Characterization of Histopathology and Microbiota in Contemporary Regenerative Endodontic Procedures: Still Coming up Short. J Endod. 47:1285-1293, 2021. [link] 

• Min H, Baek K, Lee A, Seok YJ, Choi Y. Genomic characterization of four Escherichia coli strains isolated from oral lichen planus biopsies. J Oral Microbiol.13:1905958, 2021. [link]

• Kim HD, Lee CS, Cho HJ, Jeon S, Choi YN, Kim S, Kim D, Lee HJ, Vu H, Jeong HJ, Kim B. Diagnostic Ability of Salivary Matrix Metalloproteinase-9 Lateral-Flow-Test Point-of-Care Test for Periodontitis. J Clin Periodontol. 47(11):1354-1361, 2020. [link]

• Ji S, Choi Y. Microbial and Host Factors That Affect Bacterial Invasion of the Gingiva. J Dent Res. 99: 1013-1020, 2020. [link]

• Lee J, Alam J, Choi E, Ko YK, Lee A, Choi Y. Association of a dysbiotic oral microbiota with the development of focal lymphocytic sialadenitis in IkB-z-deficient mice. NPJ Biofilms Microbiomes. 6(1):1-11, 2020. [link]

• Hong J, Park HK, Park S, Lee A, Lee YH, Shin DY, Koh Y, Choi JY, Yoon SS, Choi Y, Kim I. Strong association between herpes simplex virus-1 and chemotherapy-induced oral mucositis in patients with hematologic malignancies. Korean J Intern Med. 35(5):1188-1198, 2020. [link]

• Lee JY, Choi YY, Choi Y, Jin BH. Efficacy of non-surgical treatment accompanied by professional toothbrushing in the treatment of chronic periodontitis in patients with type 2 diabetes mellitus: a randomized controlled clinical trial. J Periodontal Implant Sci. 50(2):83‐96, 2020. [link]

• Alam J, Lee A, Lee J, Kwon DI, Park HK, Park JH, Jeon S, Baek K, Lee J, Park SH, Choi Y. Dysbiotic oral microbiota and infected salivary glands in Sjögren's syndrome. PLoS One. 15(3):e0230667, 2020. [link]

• Kim HD, Kim S, Jeon S, Kim SJ, Cho HJ, Choi YN. Diagnostic and Prognostic ability of salivary MMP-9 and S100A8 for periodontitis. J Clin Periodontol. 47(10):1191-1200, 2020. [link]

• Lee A, Hong J, Shin DY, Koh Y, Yoon SS, Kim PJ, Kim HG, Kim I, Park HK, Choi Y. Association of HSV-1 and Reduced Oral Bacteriota Diversity with Chemotherapy-Induced Oral Mucositis in Patients Undergoing Autologous Hematopoietic Stem Cell Transplantation. J Clin Med. 9(4):1056, 2020. [link]

• Lee YH, Hong J, Kim I, Choi Y, Park HK. Prospective evaluation of clinical symptoms of chemotherapy-induced oral mucositis in adult patients with acute leukemia: A preliminary study. Clin Exp Dent Res. 6:90-99, 2020. [link]

• Baek K, Lee J, Lee A, Lee J, Yoon HJ, Park HK, Chun J, Choi Y. Characterization of intratissue bacterial communities and isolation of Escherichia coli from oral lichen planus lesions. Sci Rep.10:3495, 2020. [link]

• Liu M, Lee JW, Jung S, Ji S, Choi Y. Ability of S100 proteins and matrix metalloproteinase-9 to identify periodontitis in a ligature-induced periodontitis dog model. J Clin Periodontol. 47:182-192, 2020. [link]

• Jeon S, Lee J, Park SH, Kim HD, Choi Y. Associations of Anti-Aquaporin 5 Autoantibodies with Serologic and Histopathological Features of Sjögren's Syndrome. J Clin Med. 8. pii: E1863, 2019. [link]

• Jang JY, Baek KJ, Choi Y, Ji S. T helper 1 and 2 stimuli induce distinct phenotypes in gingival fibroblasts. Arch Oral Biol. 102:171-178, 2019. [link]

• Choi YS, Baek K, Choi Y. Estrogen reinforces barrier formation and protects against tumor necrosis factor alpha-induced barrier dysfunction in oral epithelial cells. J Periodontal Implant Sci. 48:284-294, 2018. [link]

• Lee A, Kim YC, Baek K, Alam J, Choi YS, Rheu Y, Shin YJ, Kim S, Kim HD, Song YW, Choi Y. Treponema denticola enolase contributes to the production of antibodies against ENO1 but not to the progression of periodontitis. Virulence 9:1263-1272, 2018. [link]

• Baek KJ, Choi Y. The microbiology of oral lichen planus: Is microbial infection the cause of oral lichen planus? Mol Oral Microbiol. 33:22-28, 2018. [link]

• Baek KJ, Ji S, Choi Y. Complex intra-tissue microbiota forms biofilms in periodontal lesions. J Dental Res. 97:192-200, 2018. [link]

• Chang F, Kim JM, Choi Y, Park K. MTA promotes chemotaxis and chemokinesis of immune cells through distinct calcium-sensing receptor signaling pathways. Biomaterials. 150:14-24, 2018. [link]

• Alam J, Koh JH, Kwok S-K, Park S-H, Park K, Choi Y. Functional epitopes for anti-aquaporin 5 antibodies in Sjögren’s syndrome. J Dental Res. 96:1414-1421, 2017. [link]

• Namkoong E, Lee SW, Kim N, Choi Y, Park K. Effect of anti-muscarinic autoantibodies on leukocyte function in Sjögren's syndrome. Mol Immunol. 90:136-142, 2017. [link]

• Abdi K, Chen T, Klein BA, Tai AK, Coursen J, Liu X, Skinner J, Periasamy S, Choi Y, Kessler BM, Palmer RJ, Gittis A, Matzinger P, Duncan MJ, Singh NJ. Mechanisms by which Porphyromonas gingivalis evades innate immunity. PLoS One. 12:e0182164, 2017. [link]

• Jang JY, Baek KJ, Choi Y, Ji S. Relatively low invasive capacity of Porphyromonas gingivalis strains into human gingival fibroblasts in vitro. Arch Oral Biol. 83, 265-271, 2017. [link]

• Jang JY, Song I-S, Baek KJ, Choi Y, Ji S. Immunologic characteristics of human gingival fibroblasts in response to oral bacteria. J Periodontal Res. 52:447-457, 2017. [link]

• Park J-Y, Chung H, Choi Y, Park J-H. Phenotype and Tissue Residency of Lymphocytes in the Murine Oral Mucosa. Front Immunol. 8:250, 2017. [link]

• Alam J, Choi YS, Koh JH, Kwok SK, Park SH, Song YW, Park K, Choi Y. Detection of Autoantibodies against Aquaporin-1 in the Sera of Patients with Primary Sjögren's Syndrome. Immune Netw. 17:103-109, 2017. [link]

• Baek KJ, Choi YS, Kang CK, Choi Y. The proteolytic activity of Porphyromonas gingivalis is critical in a murine model of periodontitis. J Periodontol. 88:218-224, 2017. [link ]

• Alam J, Koh JH, Kim N, Kwok S-K, Park S-H, Song YW, Park K, Choi Y. Detection of autoantibodies against aquaporin 5 in the sera of patients with primary Sjögren’s syndrome. Immunol Res. 64: 845-856, 2016. [link ]

• Choi YS, Kim YJ, Yoon HJ, Baek KJ, Alam J, Park HK, Choi Y. The presence of bacteria within tissue provides insights into the pathogenesis of oral lichen planus. Scientific Rep. 6:29186, 2016. [link]

• Kim YJ, Choi YS, Baek KJ, Yoon SH, Park HK, Choi Y. Mucosal and salivary microbiota associated with recurrent aphthous stomatitis. BMC Microbiol. 16 Suppl 1:57, 2016. [link]

• Kim YC, Choi YS, Alam J, Kim YJ, Baek KJ, Koh J, Song YW, Chung DH, Choi Y. Induction of proteinase 3-anti-neutrophil cytoplasmic autoantibodies by proteinase 3-homologous bacterial protease in mice. Immunol Res. 64:438-444, 2016. [link]

• Ji S, Choi YS, Choi Y. Bacterial invasion and persistence: critical events in the pathogenesis of periodontitis? J Periodontal Res. 50:570-585, 2015. [link]

• Ji S, Choi Y. Point-of-care diagnosis of periodontitis using saliva: technically feasible but still a challenge. Front Cell Infect Microbiol. 5:65, 2015. [link]

• Lee HK, Ji S, Park SJ, Choung HW, Choi Y, Lee HJ, Park SY, Park JC. Odontogenic ameloblast-associated protein (ODAM) Mediates Junctional Epithelium Attachment to Tooth via Integrin-ODAM-ARHGEF5-RhoA Signaling. J Biol Chem. 290:14740-14753, 2015. [link]

• Choi YS, Kim YC, Baek KJ, Choi Y. In Situ Detection of Bacteria within Paraffin-embedded Tissues Using a Digoxin-labeled DNA Probe Targeting 16S rRNA. J Vis Exp. 99:e52836, 2015. [link ]

• Baek KJ, Ji S, Kim YC, Choi Y. Association of the invasion ability of Porphyromonas gingivalis with the severity of periodontitis. Virulence 6:274-281, 2015. [link]

• Alam J, Baek KJ, Choi YS, Kim YC, Choi Y. N-acetylcysteine and the human serum components that inhibit bacterial invasion of gingival epithelial cells prevent experimental periodontitis in mice. J Periodontal Implant Sci. 44: 266-273, 2014. [link] 

• Choi YS, Kim YC, Ji S, Choi Y. Increased Bacterial Invasion and Differential Expression of Tight Junction Proteins, Growth Factors, and Growth Factor Receptors in Periodontal Lesions. J Periodontol. 85: e312-e322, 2014. [link]

• Jo A, Baek KJ, Shin JE, Choi Y. Mechanisms of IL-8 suppression by Treponema denticola in gingival epithelial cells. Immunol Cell Biol. 92:139-147, 2014. [link]

• Baek KJ, Choi Y, Ji S. Gingival fibroblasts from periodontitis patients exhibit inflammatory characteristics in vitro. Arch Oral Biol. 58:1282-1292, 2013. [link]

• Shin JE, Baek KJ, Choi YS, Choi Y. A periodontal pathogen Treponema denticola hijacks the Fusobacterium nucleatum-driven host response. Immunol Cell Biol. 91:503-510, 2013. [link]

• Choi YS, Kim YC, Jo AR, Ji S, Koo K-T, Ko Y, Choi Y. Porphyromonas gingivalis and dextran sulfate sodium induce periodontitis through the disruption of physical barriers in mice. European J Inflamm. 11:419-431, 2013. [link]

• Ji S, Choi Y. Innate immune response to oral bacteria and the immune evasive characteristics of periodontal pathogens. J Periodontal Implant Sci. 43: 3-11, 2013. [link]

• Shin J, Kho S-A, Choi YS, Kim YC, Rhyu I-C, Choi Y. Antibody and T Cell Responses to Fusobacterium nucleatum and Treponema denticola in Health and Chronic Periodontitis. PLoS One. 8:e53703, 2013. [link]

• Shin J, Choi Y. The fate of Treponema denticola within human gingival epithelial cells. Mol Oral Microbiol. 27:471-482, 2012. [link]

• Kim Y, Jo A, Jang DH, Cho Y-J, Chun J, Min B-M, Choi Y. Toll-like receptor 9 mediates oral bacteria-induced IL-8 expression in gingival epithelial cells. Immunol Cell Biol. 90:655-663, 2012. [link]

• Punwani D, Simon K, Choi Y, Dutra A, Gonzalez-Espinosa D, Pak E, Naradikian M, Song CH, Zhang J, Bodine DM, Puck JM. Transcription Factor Zinc Finger and BTB Domain 1 Is Essential for Lymphocyte Development. J Immunol. 189:1253-1264, 2012. [link]

• Kim YC, Shin JE, Lee SH, Chung WJ, Lee YS, Choi BK, Choi Y. Membrane-bound proteinase 3 and PAR2 mediate phagocytosis of non-opsonized bacteria in human neutrophils. Mol Immunol. 48:1966-1974, 2011. [link]

• Ji S, Shin JE, Kim YC, Choi Y. Intracellular degradation of Fusobacterium nucleatum in human gingival epithelial cells. Mol Cells. 30:519-526, 2010. [link]

• Kim YC, Ko Y, Hong S-D, Kim KY, Lee YH, Chae C, Choi Y. Presence of Porphyromonas gingivalis and Plasma Cell Dominance in Gingival Tissues with Periodontitis. Oral Dis. 16: 375-381, 2010. [link]

• Shin JE, Choi Y. Treponema denticola suppresses expression of human beta-defensin-2 in gingival epithelial cells through inhibition of TNFa production and TLR2 activation. Mol Cells. 29: 407-412, 2010. [link ]

• Chun J, Kim KY, Lee J-H, Choi Y. The analysis of oral microbial communities of wild-type and toll-like receptor 2-deficient mice using a 454 GS FLX Titanium pyrosequencer. BMC Microbiol. 10: 101, 2010. [link]

• Shin JE, Kim YS, Oh J-E, Min B-M, Choi Y. Treponema denticola suppresses expression of human beta-defensin-3 in gingival epithelial cells through inhibition of TLR2 activation axis. Infect Immun. 78: 672-679, 2010. [link]

• Kurokawa K, Lee H, Roh KB, Asanuma M, Kim YS, Nakyama H, Shiratsuchi A, Choi Y, Takeuchi O, Kang HJ, Dohmae N, Nakanishi Y, Akira S, Sekimizu K, Lee BL. The triacylated ATP binding cluster transporter substrate-binding lipoprotein of Staphylococcus aureus functions as a native ligand for the toll-like receptor 2. J Biol Chem. 284: 8406-8411, 2009. [link]

•  Ji S, Shin JE, Kim YS, Oh J-E, Min B-M, Choi Y. TLR2 and NALP2 mediate induction of human beta-defensins by Fusobacterium nucleatum in gingival epithelial cells.  Infect Immun. 77: 1044-1052, 2009. [link]

• Park O-J, Shin S-Y, Choi Y, Kim M-H, Chung C-P, Ku Y, Kim K-K. The Association of Osteoprotegerin Gene Polymorphisms with Periodontitis. Oral Dis.14: 440-444, 2008. [link]

• Yang  J, Park OJ, Lee YJ, Jung H-M, Woo KM, Choi Y. 4-1BB ligand and 4-1BB expressed on osteoclast precursors enhance RANKL-induced osteoclastogenesis via bi-directional signaling. Eur J Immunol. 38: 1598-1609, 2008. [link]

• Shin JE, Ji S, Choi Y. Ability of Oral Bacteria to Induce Tissue-destructive Molecules from Human Neutrophils. Oral Dis. 14: 327-334, 2008. [link]

• Chang S, Choi Y, Hwang H-J, Jung D-S, Shin J, Yang J-H, Ko S-Y, Kim S-W, Kim J-K. Anti-inflammatory effects of BT-201, an n-butanol extract of Panax notoginseng, observed in vitro and in a collagen-induced arthritis model. Clin Nutr. 26: 785-791, 2007. [link]

• Ji S, Kim YS, Min B-M, Han SH, Choi Y. Innate Immune Responses of Gingival Epithelial Cells to Non-periodontopathic and Periodontopathic Bacteria. J Periodontal Res. 42: 503-510, 2007. [link]

• Ji S, Hyun J, Park E, Lee B-L, Kim K-K, Choi Y. Susceptibility of Various Oral Bacteria to Antimicrobial Peptides and to Phagocytosis by Neutrophils. J Periodontal Res. 42: 410-419, 2007. [link]

• Kim HA, Kim S, Chang SH, Hwang HJ, Choi Y. Anti-arthritic effect of ginsenoside Rb1 on collagen induced arthritis in mice. Int Immunopharmacol. 7: 1286-1291, 2007. [link]

• Park H, Park O-J, Shin J, Choi Y. Receptor activator of NF-kB ligand enhances the activity of macrophages as antigen presenting cells. Exp Mol Med. 37: 524-532, 2005. [link]

• Park H, Jung Y-K, Park O-J, Lee YJ, Choi J-Y, Choi Y. Interaction of Fas ligand (FasL) and Fas expressed on osteoclast precursors increases osteoclastogenesis. J Immunol. 175: 7193-7201, 2005. [link]

• Chang S-H, Sung H-C, Choi Y, Ko S-Y, Lee B-E, Back D-H, Kim S-W, Kim J-K. Suppressive Effect of AIF, a water extract of three herb, on collagen-induced arthritis in mice. Int Immunopharmacol. 5:1365-1372, 2005. [link] 

• Choi Y Kim JJ. B cells activated in the presence of Th1 cytokines inhibit osteoclastogenesis. Exp Mol Med. 35: 385-392, 2003. [link] 

• Woo KM, Choi Y, Ko S-H, Ko JS, Oh K-O, Kim KK. Osteoprotegerin is present on the membrane of osteoclasts isolated from mouse long bones. Exp Mol Med. 34: 347-352, 2002. [link]

• Choi Y, Simon-Stoos K, Puck JM. Hypo-active variant of IL-2 and associated decreased T-cell activation contribute to impaired apoptosis in autoimmune prone MRL mice. Eur J Immunol. 32: 677-684, 2002. [link] 

• Choi Y, Woo KM, Ko S-H, Lee YJ, Park S-J, Kim H-M, Kwon BS. Osteoclastogenesis is enhanced by activated B cells but suppressed by activated CD8+ T cells. Eur J Immunol. 31: 2179-2188, 2001.[link]