Publications
Selected publication
(* Co-first, #Co-coresponding)
Multidimensional control of therapeutic human cell function with synthetic gene circuits
Hui-Shan Li*, Divya V Israni*, Keith A Gagnon, Kok Ann Gan, Michael H Raymond, Jeffry D Sander, Kole T Roybal, J Keith Joung, Wilson W Wong, Ahmad S Khalil
Science, 378(6625):1227-1234 (2022)
Commentary in Science by Emanuel Salazar-Cavazos & Grégoire Altan-Bonnet (link);
Nature by Heidi Ledford (link);
The Scientist by Natalia Mesa (link);
El Pais by Daniel Mediavilla (link);
Nature by Heidi Ledford (link)
High-performance multiplex drug-gated CAR circuits
Hui-Shan Li*, Nicole M Wong*, Elliot Tague, John T Ngo, Ahmad S Khalil, Wilson W Wong
Cancer Cell, 40 (11): 1294-1305 (2022)
Commentary in The Brink (Boston University) by Jessica Colarossi (link)
Nature chemical biology by Grant Miura (link)
Cancer Cell by Jiqin Zhang ,Bing Du& Mingyao Liu (link)
Nasal immunization with mannan-decorated mucoadhesive HPMCP microspheres containing ApxIIA toxin induces protective immunity against challenge infection with Actinobacillus pleuropneumoiae in mice
Hui-Shan Li, Min-Kyoung Shin, Bijay Singh, Sushila Maharjan, Tae-Eun Park, Sang-Kee Kang, Han-Sang Yoo, Zhong-Shan Hong, Chong-Su Cho#, Yun-Jaie Choi #
Journal of Controlled Release, 233: 114-125 (2016)
Mannan decorated thiolated Eudragit microspheres for targeting antigen presenting cells via nasal vaccination
Hui-Shan Li, Bijay Singh, Tae-Eun Park, Zhong-Shan Hong, Sang-Kee Kang, Chong-Su Cho#, Yun-Jaie Choi#
European Journal of Pharmaceutical Sciences, 80: 16-25 (2015)
Recombinant interleukin 6 with M cell-targeting moiety produced in Lactococcus lactis IL1403 as a potent mucosal adjuvant for peroral immunization
Hui-Shan Li, Da-Chuan Piao, Tao Jiang, Jin-Duck Bok, Chong-Su Cho, Yoon-Seok Lee, Sang-Kee Kang#, Yun-Jaie Choi#
Vaccine, 33(16): 1959-1967 (2015)
Full publication (by year)
(* Co-first, #Co-coresponding)
18. Li, H.S.*, Israni, D.V.*, Gagnon, K.A., Sander, J., Joung, J.K., Wong, W.W., Khalil, A.S. Multidimensional user control of human cell function with clinically-inspired synthetic gene switches. Science. 2022.
17. Li, H.S.*, Wong, N.M.*, Tague, E, Ngo, J.T., Khalil, A.S., Wong, W.W. High-performance multiplex drug-gated CAR circuits. Cancer Cell. 2022.
16. Islam, M. A., Park, T. E., Firdous, J., Li, H. S., Jimenez, Z., Lim, M., Choi, J.W., Yun, C.H., Cho, C. S. Essential cues of engineered polymeric materials regulating gene transfer pathways. Progress in Material Science. 2022.
15. Yoon, S.Y., Kang, S.K., Lee, H.B., Oh, S.H., Kim, W.S., Li, H.S., Bok, J.D., Cho, C.S. and Choi, Y.J. Enhanced efficacy of immunization with a foot-and-mouth disease multi-epitope subunit vaccine using mannan-decorated inulin microparticles. Tissue Engineering and Regenerative Medicine. 2020.
14. Cui, L.H., Yan, S.G., Li, H.S., Kim, H.S., Hong, L., Kang, S.K., Choi, Y.J., Cho, C.S. A new method of producing a natural antibacterial peptide by encapsulated probiotics internalized with inulin nanoparticles as prebiotics. Journal of Microbiology and Biotechnology. 2018.
13. Jiang, H.L., Xing, L., Luo. C.Q., Zhou, T.J., Li, H.S., Cho, C.S. Chemical modification of chitosan as a gene transporter. Current Organic Chemistry. 2018.
12. Jiang, H.L., Islam, M.A., Xing, L., Firdous, J., Cao, W. He, H.Y., Zhu, Y., Cho, K.H., Li, H.S., Cho, C.S. Degradable polyethylenimine-based gene carriers for cancer therapy. Topics in Current Chemistry. 2017.
11. Li, H.S.*, Jiang, T.* Singh, B., Han, G. G., Kang, S.K., Bok, J.D., Kim, D.D., Choi, Y.J.#, Cho, C.S.# Oral delivery of probiotics in poultry using pH-sensitive tablets. Journal of Microbiology and Biotechnology. 2017.
10. Piao. D.C., Shin. D.W., Kim. I.S., Li. H.S., Oh. S.H., Singh. M., Maharjan. S., Lee.Y.S., Bok. J.D., Cho. C.S., Hong. Z.S., Kang. S.K., Choi, Y.J. Trigger factor assisted soluble expression of recombinant spike protein of porcine epidemic diarrhea virus in Escherichia coli. BMC biotechnology. 2016.
9. Li, H.S., Shin, M.K., Singh, B., Maharjan, S., Yoo, H.S., Kang, S.K., Hong, Z.S., Cho, C.S., Choi, Y.J. Nasal immunization with mucoadhesive and mannan decorated HPMCP microsphere containing ApxIIA toxin induces protective immunity against challenge infection with Actinobacillus pleuropneumoiae in mice. Journal of controlled release. 2016.
8. Maharjan, S., Singh, B., Jiang, T., Yoon, S.Y., Li, H.S., Kim G., Gu, M.J., Kim, S.J., Park, O.J., Han, S.H., Kang, S.K., Yun, C.H., Choi, Y.J., Cho, C.S. Systemic administration of RANKL overcomes the bottleneck of oral vaccine delivery through microfold cells in ileum. Biomaterials. 2016.
7. Kim, J.I., Park, T.E., Maharjan, S., Li, H.S., Lee, H.B., Kim, I.S., Piao, D.C., Lee, J. Y., Cho, C.S., Bok, J.D., Hong, Z.S., Kang, S.K., Choi, Y.J Soluble RANKL expression in Lactococcus lactis and investigation for its potential as an oral vaccine adjuvant, BMC immunology. 2015.
6. Li, H.S., Singh, B, Park, T.E, Hong, Z.S., Kang, S.K., Cho, C.S.*, Choi, Y.J.* Mannan decorated thiolated Eudragit microspheres for targeting antigen presenting cells via nasal vaccination.European journal of pharmaceutical science. 2015.
5. Lee, J.Y., Kang, S.K., Li, H.S., Choi, C.Y., Park, T.E., Bok, J.D., Lee, S.H., Cho, C.S., Choi, Y.J. Production of recombinant human growth hormone conjugated with a transcytotic peptide in Pichia pastoris for effective oral protein delivery. Molecular Biotechnology. 2015.
4. Li, H.S., Piao, D.C., Jiang, T., Bok, J.D., Cho, C.S., Lee, Y.S., Kang, S.K.*, Choi, Y.J.* Recombinant interleukin 6 with M cell-targeting moiety produced in Lactococcus lactis IL1403 as a potent mucosal adjuvant for peroral immunization. Vaccine. 2015.
3. Park, T.E., Singh, B., Li, H.S., Lee, J.Y., Kang, S.K., Choi, Y.J., Cho, C.S.* Enhanced BBB permeability of osmotically active poly (mannitol-co-PEI) modified with rabies virus glycoprotein via selective stimulation of caveolar endocytosis for RNAi therapeutics in Alzheimer’s disease. Biomaterials. 2015.
2. Jiang, T., Singh, B., Maharjan, S., Li, H.S., Kang, S.K., Bok, J.D., Cho, C.S. *, Choi, Y.J. * Oral delivery of probiotic expressing M cell homing peptide conjugated BmpB vaccine encapsulated into alginate/chitosan/alginate microcapsules. European journal of pharmaceutics and biopharmaceutics. 2014.
1. Jiang, T., Singh, B., Li, H.S., Kim, Y.K., Kang, S.K., Nah, J.W., Choi, Y.J., Cho, C.S. Targeted oral delivery of BmpB vaccine using porous PLGA microparticles coated with M cell homing peptide-coupled chitosan. Biomaterials. 2014.