Exposure to endocrine disrupting compounds (EDCs) generates growing and significant health and environmental concerns. Despite considerable progress on this matter during the last decades, there remain many challenges to overcome. Significant efforts are still required for the identification of EDCs, elucidating their precise mechanisms of action, understanding their effects and conducting appropriate/satisfactory risk assessments. In this context, a major goal of this international summer school is to contribute to this general effort by training young researchers in the field of endocrine disruption and providing them with the sufficient background needed to apprehend the whole extent of the issue. This will be accomplished through lectures, theoretical courses and tutorials given by world renown experts in their field and covering subjects ranging from European regulation and health risk assessment to key neuroendocrine systems such as the thyroid, reproductive and metabolic system. This summer school will also address exposure measurement methods, critical periods of exposure sensitivity, cohort analyses, and a societal component including studies estimating the burden and costs of endocrine disruption-related diseases. Innovative strategies for improved detection of low dose effects of EDCs, and their modes/mechanisms of action in model organisms such as insects, aquatic vertebrates and mammals will also be introduced. One of the originalities of this initiative is to combine theoretical and practical knowledge centered on the disruption of neuroendocrine systems.