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In-situ drug repository and on-demand drug release from the localized tissue environment
In-situ drug repository and on-demand drug release from the localized tissue environment
Research on in-situ drug repositories and on-demand drug release from the localized tissue environment presents a promising avenue for advancing drug delivery strategies. This approach involves the development of implantable or injectable devices capable of storing and releasing therapeutic agents directly at the site of action within the body. By harnessing this technology, researchers aim to overcome the limitations of conventional drug delivery systems, such as systemic administration and poor tissue penetration, while maximizing therapeutic efficacy and minimizing adverse effects. These in-situ drug repositories offer the potential for sustained and controlled release of therapeutics, allowing for precise modulation of drug concentrations at the target site over extended periods. Moreover, the ability to trigger drug release on demand in response to specific physiological cues or external stimuli further enhances the versatility and applicability of these systems. This enables drug delivery regimens tailored to individual patient needs, improving treatment outcomes and patient compliance. Additionally, in-situ drug repositories hold promise for a wide range of clinical applications, including localized treatment of cancer, chronic pain management, regenerative medicine, and wound healing. By harnessing the capabilities of these innovative drug delivery systems, researchers can unlock new opportunities for personalized medicine and targeted therapies, ultimately improving patient care and quality of life..
Understanding the fate of nanoparticle-based nanomedicines inside the cellular environment
Understanding the fate of nanoparticle-based nanomedicines inside the cellular environment
Research focused on understanding the fate of nanoparticle-based nanomedicines within the cellular environment holds immense potential for revolutionizing healthcare. By unraveling the intricate pathways through which these nanoparticles interact with cells, researchers can gain crucial insights into their biodistribution, cellular uptake mechanisms, intracellular trafficking, and eventual fate. This knowledge can pave the way for developing more effective and targeted drug delivery systems, enabling precise delivery of therapeutics to specific cellular targets while minimizing off-target effects and systemic toxicity. Additionally, understanding the cellular fate of nanoparticle-based nanomedicines can aid in optimizing their pharmacokinetic profiles, enhancing their therapeutic efficacy, and improving patient outcomes. Moreover, insights gained from this research can inform the design of next-generation nanomedicines with enhanced biocompatibility, stability, and functionality, opening up new possibilities for personalized medicine and targeted therapies. Ultimately, by deciphering the fate of nanoparticle-based nanomedicines within the cellular milieu, researchers can accelerate the translation of innovative nanotechnologies from the laboratory to the clinic, ushering in a new era of precision medicine and improved patient care.
Nanomaterials in biosensing and continuous monitoring systems
Nanomaterials in biosensing and continuous monitoring systems
Learning from the pandemic, we have witnessed the efficient utilization of the nanomaterials in fabricating point-of-care lateral flow detection systems against the CoVID-19 antigen. More recently, nanocomposites made from hydrogels and polymeric matrix incorporating catalytic nanomaterials and enzymes have been used for sensitive non-invasive or minimal invasive blood pressure, cardiac disease and glucose monitoring systems. Polymeric nanomaterials such as thin, flexible films and microneedle fabrication technologies have met significant goals in this area. Further, several innovative strategies have incorporated metal oxide, metal halides and carbon-based materials for in vitro sensing of the biomarkers by exploiting the nanomaterial’s robustness and environmental favorability. It is seen that the redox property and catalytic traits of the nanomaterials largely govern the fate of the biosensors, thus leaving sufficient room for alteration of these bio-material reactions that may improve their sensitivity.
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