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Many people have become pregnant after receiving a COVID-19 vaccine, including some who got vaccinated during COVID-19 vaccine clinical trials.6-8 In addition, a recent report using the COVID-19 vaccine pregnancy safety monitoring system data showed that 4,804 people had a positive pregnancy test after receiving the first dose of an mRNA COVID-19 vaccine. Another report using data from eight U.S. healthcare systems documented more than 1,000 people who completed COVID-19 vaccination (with any COVID-19 vaccine) before becoming pregnant.

COVID-19 vaccines are undergoing the most intense safety monitoring in U.S. history. Data continue to accumulate and show that COVID-19 vaccines are safe and effective for use before and during pregnancy.

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Fever, for any reason, has been associated with adverse pregnancy outcomes. Fever in pregnancy may be treated with acetaminophen as needed, and in consultation with a healthcare provider. It is not recommended you take these medicines before vaccination to try to prevent side effects. Learn about other ways to relieve side effects.

However, anyone who is trying to or expecting to become pregnant should avoid alcohol, as it can affect fetal development. Drinking during early pregnancy can increase the risk of miscarriage, premature birth, and low birth weight.

HCG can rise as a result of some types of cancer. These are transitional cell carcinoma of the bladder and urinary tract, prostate cancer, renal cancer, and cancers of the gastrointestinal system. A pregnancy test may be used to assess for these.

Pregnancy tests are available at drugstores, pharmacies, and some convenience stores. Home pregnancy tests can be purchased for as little as a dollar, and some health centers offer them free of charge.

A progesterone test measures the level of progesterone in a sample of your blood. Progesterone is a hormone that's made mainly by the ovaries, which are two glands in the female reproductive system that contain eggs.

Each month, progesterone prepares your uterus for pregnancy. During a normal menstrual cycle, an ovary releases an egg and your progesterone levels begin to rise. Progesterone makes the lining of your uterus grow thicker so that a fertilized egg can attach (implant) inside of the uterus and grow into a baby.

If you become pregnant, progesterone levels will continue to rise to about 10 times higher than usual to support the pregnancy. High levels of progesterone prevent the uterus from contracting (squeezing) and causing pre-term labor. Much of the progesterone you need for a healthy pregnancy is made by the placenta. The placenta is the organ that grows in the uterus to provide nutrients and oxygen to the unborn baby.

A progesterone test can help show whether low progesterone levels are causing female infertility (problems getting pregnant after a year of trying) or problems during pregnancy. The test may also help diagnose certain problems with the adrenal glands that may cause high levels of progesterone in both females and males.

A health care professional will take a blood sample from a vein in your arm, using a small needle. After the needle is inserted, a small amount of blood will be collected into a test tube or vial. You may feel a little sting when the needle goes in or out. This usually takes less than five minutes.

You usually don't need any other preparations for a progesterone test. In certain cases, you may need to know the first day of your last menstrual period. Your provider will tell you if you need to stop taking any medicines before the test. But never stop taking medicine unless your provider tells you.

High progesterone levels may also be a sign of a molar pregnancy, which is an abnormal growth of tissue in the uterus. It's caused by a fertilized egg with such severe genetic problems that it cannot become a baby. The growth can turn into cancer and must be removed.

If you do not want to continue with the pregnancy you may decide to have an abortion. If you are unsure and want to talk about it more, you can make an appointment with your local sexual health clinic or your GP.

We still think Clearblue Digital is the best choice if you prefer a digital wand test. And we now recommend test strips from MomMed, which are nearly as sensitive as First Response Early Result wands, but they cost far less per test.

For this guide, we interviewed Dr. Brindha Bavan, an obstetrician-gynecologist, reproductive endocrinologist, and fertility specialist at Stanford Medicine; Dina Greene, PhD, a clinical associate professor of chemistry at the University of Washington who has co-authored several published studies on hCG testing in clinical settings; and David Grenache, PhD, chief scientific officer at a diagnostic testing company and a clinical professor of pathology at the University of New Mexico who has studied hCG for more than 15 years.

Once the body begins producing more hCG, its amount in the blood and urine roughly doubles every two or three days for the first eight to nine weeks of pregnancy. After implantation, someone might have anywhere from 5 to 50 mIU/mL of hCG in their pee (mlU/mL means milli-International Units per milliliter, a standardized unit).

It is also possible to get a false negative result after using a test on a day the box says it should be 99% accurate. This is because of how different the levels of urine hCG are from person to person, and even how much they can change throughout the day in the same person. Your hCG may be on the low end, or your pee may be very dilute.

So how do the tests actually detect hCG? Most of the action takes place along a narrow strip of a special absorbent type of paper. Each strip is pre-loaded with molecules needed to detect hCG and create a colored band and a control band. As urine containing hCG gets wicked up the paper, it passes areas where those molecules have been deposited.

We chose 26 tests to try based on their popularity and availability, as well as their ratings at online retailers. We also walked into pharmacy chains and big-box retailers to see what someone in need of a test ASAP might find on the shelves. We then looked at the following:

I compared the time it took for each test to develop with the time claimed on the packaging, and I then examined the readability of the control line and took note of any faulty tests or false positives. Leigh Krietsch Boerner, who was pregnant while assessing tests for an earlier version of this review, compared positive lines and looked out for any false negatives. She also used urine diluted by 1,000 times in water to see what a faintly positive line looked like on several tests.

In addition, in our own (unscientific) testing, this test gave the clearest positive reading to a very dilute solution of pregnancy pee. As you can see in the photo, the First Response wand (at bottom) showed a very clear positive response with a strong fuchsia line, while the other pregnancy tests barely registered faint blue marks.

In addition, its ultra-high sensitivity makes the First Response Early Result test more likely to detect chemical pregnancies, which Dr. Bavan said could cause false hope and then letdown for people who are trying to conceive, as well as unnecessary stress for people hoping for a negative result.

There are other rare situations where a more sensitive test could be more likely to give false positive results. For example, hCG can increase during perimenopause. One study found that 1.3% of home pregnancy tests taken by women ages 41 to 55 would be false positives. The manufacturer reported to the FDA a similar rate of false positives for this age group.

Similar to First Response Early Result, Clearblue Early Detection can detect pregnancy five days before an expected period 71% of the time (that goes up to 94% four days before, 98% three and two days before, and 99% a day before an expected period). Unlike other Clearblue pregnancy tests, this wand test also uses pink lines rather than blue, which some people find easier to read.

As with all digital wand tests, this one costs more than traditional (non-digital) wand tests, and it makes for additional electronic waste. The instructions that accompany the Clearblue Digital instruct you to dispose of the test (which, like all digital tests, includes a battery) according to local regulations.

MomMed Pregnancy Test strips are as well vetted as all the other tests we recommend, and they meet the requirements to detect 25 mIU/mL of hCG in urine. The manufacturer, Co-Innovation, tested for the hook effect and variant hook effect up to the same levels as the manufacturer of First Response tests has. Like all test strips, these can only be used with the dip method, and they are intended to be used the day after a missed period at the earliest.

If you can wait longer to test and want something inexpensive that you can get at a store quickly: We like the Equate First Signal One Step test (currently 88) from Walmart. This simple and effective test produces a clear, dark pink control band, and its results are easy to read. Like test strips, this cassette-style test requires you to pee into a cup. (Unlike test strips, this test has you use a supplied dropper to add urine to the test strip.) Walmart gets these from a medical device company that has shown the test can detect 25 mIU/ml hCG. The Equate cassette is not useful for detecting very low amounts of hCG, and some customer reviewers have reported false negative results when using this test.

EPT claims its test to be 99% accurate from the day of an expected period. It has really skinny handles that feel top-heavy. In our experience, the plastic film covering the test window sometimes got stuck to the strip inside, creating a vertical line that could easily be confused for a positive result, as some customer reviewers have reported.

The Modern Fertility wand test has a high claimed sensitivity and is easy to read. However, the wand is small and dainty compared with our picks and most store-brand tests, including the similarly priced Target (Up & Up) Advanced Early Result (you could fit an individually wrapped wand in your pocket, making it a good, discrete option if you prefer wand tests to strips). Modern Fertility wand tests use the same strips as Easy@Home (Wondfo), but the company says they have a higher sensitivity (10 mIU/mL) and accuracy (68% five days before an expected period, 89% at four days, 97% at three days, 98% at two days, and 99% the day of). We have not tested the accompanying app. 2351a5e196