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The overall evidence in this review is graded as low and can only be interpreted as a indication that early compared to late tracheostomy may be recommended to shorten the duration of MV in critically-ill COVID-19 patients and to reduce all-cause mortality.

Conclusions: Following proning, there was significant improvement in oxygenation. Cycles lasted for 16 h consistent with current ARDS guidelines [2]. Although the results suggest a diminishing response in those proned at later times, the PF ratio was still significant. Overall, this suggests a beneficial effect on oxygenation. However, findings cannot be translated into survival benefit. Further research including randomised controlled trials is recommended.

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Introduction: European guidelines recommend ceftriaxone or amoxicillin/clavulanate (AAC) as equally effective first-line antibiotic therapy for community-acquired pneumonia (CAP). This study aims to identify factors, including patients' clinical characteristics, that may influence the choice of beta-lactam empirical therapy for CAP and to relate this with patients' prognosis.

Introduction: In the ICU, the infection-related mortality is high (30%) and beta-lactam target non-attainment (TNA) occurs in 37% of ICU patients [1, 2]. The recommended pharmacodynamic target for beta-lactam antibiotics is 100% of the time above the minimal inhibitory concentration [1]. Antibiotic dose optimization can be performed with therapeutic drug monitoring (TDM). In this study we therefore developed prediction models for TNA in ICU patients receiving beta-lactams.

Conclusions: The findings of this study showed that the critically ill patients Bayesian dose-optimizing program using peak and trough produce estimated AUC more accurate and with less bias. These results give an empirical basis to support the recommendations of current clinical guidelines.

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