Mechanical stretch is a very basic stimulus that can influence every peripheral tissue. Our laboratory is interested in how it is sensed at the periphery and how it interacts with tissue-resident immune cells to regulate biological functions under various perturbed conditions.

The cells in our body communicate with each other at all times. Since our body is composed of various types of cell, such as immune cells, stromal cells and neurons, understanding their 'language' is critical to interpreting how this communication manifests as biological function. Our lab focuses on how these cells communicate with each other and the consequences of these conversations in the context of biological function.

Pregnancy is a biological event accompanied by systemic hormonal changes. During pregnancy maternal endocrine and immune environments are dynamically altered, and these systemic changes may perturb the central nervous system through vascular, choroid plexus, and CSF-associated interfaces. Our research focuses on how pregnancy-induced CNS perturbation reshapes neuroimmune communication, particularly the interaction between ILC2s and microglia.