Huisuk Yang, 2021

Education

• Ph.D in Department of Biotechnology Sep.2011 - Feb.2018

Yonsei University, Republic of Korea

Advisor: Prof. Hyungil Jung

• B.S. in Mechanical Engineering

B.S. in Bioengineering & Biotechnology Mar.2006 - Aug.2011

Yonsei University, Republic of Korea

• Visiting Student Program Jun.2008 - Jul.2008

University of California Los Angeles, U.S.A.

Experiences

• JUVIC Inc. Oct.2015 - Present

CEO

Developement of micrnoeedle-based drug delivery systems

Establishment of pharmaceutical micrnoeedle manufacturing GMP site

homepage: http://juvicbio.com/

• Raphas Co. Ltd. Sep.2011 - Mar.2012

Internship

Develeopement of cosmetic microneedle patches

Clinical trials of cosmetic microneedle products

Patented technical transfer

homepage: http://www.raphas.com/

Publications

• H. Yang, G. Kang, M. Jang, D. J. Um, J. Shin, H. Kim, J. Hong, H. Jung, H. Ahn, S. Gong, C. Lee, U. Jung, H. Jung*, "Development of Lidocaine-Loaded Dissolving Microneedle for Rapid and Ecient Local Anesthesia", Pharmaceutics, 2020, 12, 1067

• M. Jang, S. Baek, G. Kang, H. Yang, S. Kim,H. Jung*, "Dissolving Microneedle with High Molecular Weight Hyaluronic Acid to improve skin wrinkles, dermal density and elasticity", International Journal of Cosmetic Science, 2020, 42, 302

• S. Kim, H. Yang, J. Eum, Y. Ma, S. F. Lahiji, H. Jung*, "Implantable Powder-carrying Microneedles for Transdermal Delivery of High-Dose Insulin with Enhanced Activity", Biomaterials, 2020, 232, 119733

• S. Kim, J. Eum, H. Yang, H. Jung*, "Transdermal Finasteride Delivery via Powder-carrying Microneedles with Diffusion Enhancer for the Treatment of Androgenetic Alopecia", Journal of Controlled Release, 2019, 316, 1

• G. Kang, S. Kim, H. Yang, M. Jang, L. Chiang, J. H. Baek, J. H. Ryu, G. W. Choi, H. Jung*, "Combinatorial application of dissolving microneedle patch and cream for improvement of skin wrinkles, dermal density, elasticity, and hydration", Journal of Cosmetic Dermatology, 2019, 1, 1083

• H. Yang, S. Kim, M. Jang, H. Kim, S. Lee, Y. Kim, Y. A. Eom, G. Kang, L. Chiang, J. H. Baek, J. H. Ryu, Y. E. Lee, J. Koh, H. Jung*, "Two‐phase delivery using a horse oil and adenosine‐loaded dissolving microneedle patch for skin barrier restoration, moisturization, and wrinkle improvement", Journal of Cosmetic Dermatology, 2019, 18, 936

• C. Lee, H. Kim, S. Kim, S. F. Lahiji, N. Ha, H. Yang, G. Kang, H. Y. T. Nguyen, Y. Kim, M. Choi, N. Cho*, H. Jung*, "Comparative Study of Two Droplet-based Dissolving Microneedle Fabrication Methods for Skin Vaccination", Advanced Healthcare Materials, 2018, 7, 1701381

• G. Kang, T. N. T. Tu, S. Kim, H. Yang, M. Jang, D. Jo, J. Rye, J. Baek, H. Jung*, "Adenosine-loaded dissolving microneedle patches to improve skin wrinkles, dermal density, elasticity and hydration", International Journal of Cosmetic Science, 2018, 40, 199

• C. Lee, Y. A. Eom, H. Yang, M. Jang, S. U. Jung, Y. O. Park, S. E. Lee, H. Jung*, "Skin Barrier Restoration and Moisturization using Horse Oil-loaded Dissolving Microneedle Patches Short title: Skin Barrier Restoration using Dissolving Microneedles", Skin Pharmacology and Physiology, 2018, 31, 163

• S. F. Lahiji, S. H. Seo, S. Kim, M. Dangol, J. Shim, C. G. Li, Y. Ma, C. Lee, G. Kang, H. Yang, K. Choi, H. Jung*, "Transcutaneous implantation of valproic acid-encapsulated dissolving microneedles induces hair regrowth", Biomaterials, 2018, 167, 69

• S. F. Lahiji, Y. Jang, Y. Ma, M. Dangol, H. Yang, M. Jang, H. Jung*, "Effects of dissolving microneedle fabrication parameters on the activity of encapsulated lysozyme", European Journal of Pharmaceutical Sciences, 2018, 117, 290

• S. F. Lahiji, Y. Jang, I. Huh, H. Yang, M. Jang, H. Jung*, "Exendin-4-encapsulated dissolving microneedles arrays for efficient treatment of type 2 diabetes", Scientific Reports, 2018, 8, 1170

• I. Huh, S. Kim, H. Yang, M. Jang, G. Kang, H. Jung*, "Effects of two droplet-based dissolving microneedle manufacturing methods on the activity of encapsulated epidermal growth factor and ascrobic acid", European Journal of Pharmaceutical Sciences, 2018, 114, 285

• S. Kim, J. Lee, S. F. Lahiji, S. Kim, I. Huh, Y. Ma, H. Yang, G. Kang, H. Jung*, "Physicochemical study of ascorbic acid 2-glucoside loaded hyaluronic acid dissolving microneedles irradiated by electron beam and gamma ray", Carbohydrate Polymers, 2018, 180, 297

• H. Yang, S. Kim, G. Kang, S. F. Lahiji, M. Jang, Y. M. Kim, J. Kim, S. Cho, H. Jung*, "Centrifugal Lithography: Self-Shaping of Polymer Microstructures Encapsulating Biopharmaceutics by Centrifuging Polymer Drops", Advanced Healthcare Materials, 2017, 6, 1700326

• S. Kim, M. Dangol, G. Kang, S. F. Lahiji, H. Yang, M. Jang, Y. Ma, C. Li, S. G. Lee, C. H. Kim, Y. W. Choi, S. J. Kim, J. H. Ryu, J. H. Baek, J. Koh, H. Jung*, "Enhanced transdermal delivery by combined application of dissolving microneedle patch on serum treated skin", Molecular Pharmaceutics, 2017, 14, 2024

• S. Kim, M. Park, H. Yang, M. Dangol, S. F. Lahiji, I. Huh, M. Kim, J. Lee, J. Son*, H. Jung*, “Development of a quantitative method for active epidermal growth factor extracted from dissolving microneedle by solid phase extraction and liquid chromatography electrospray ionization mass spectrometry”, Journal of Pharmaceutical and Biomedical Analysis, 2016, 131, 297

• H. Yang, C. Lee, S. Kim, M. Kim, H. Kang, N. Kim, S. An, J. Koh, H. Jung*, “Evaluation of the anti-wrinkle effect of an ascorbic acid-loaded dissolving microneedle patch via a double-blind, placebo-controlled clinical study”, International Journal of Cosmetic Science, 2016, 38, 375

• M. Dangol, H. Yang, C. G. Li, S. F. Lahiji, S. Kim, Y. Ma, H. Jung*, “Innovative polymeric system (IPS) for solvent-free lipophilic drug transdermal delivery via dissolving microneedles”, Journal of Controlled Release, 2016, 223, 118

• M. Kim, H. Yang, S. Kim, C. Lee, H. Jung*, “The Troy Microneedle: A Rapidly Separating, Dissolving Microneedle Formed by Cyclic Contact and Drying on the Pillar (CCDP)”, PLoS ONE, 2015, 10, 8

• S. Kim, H. Yang, M. Kim, J. H. Baek, S. J. Kim, S. M. An, J. S. Koh, H. Jung*, “4-n-butylresorcinol dissolving microneedle patch for skin depigmentation: a randomized, double-blind, placebo-controlled trial”, Journal of Cosmetic Dermatology, 2015,15, 16

• H. Yang, S. Kim, I. Huh, S. Kim, S. F. Lahiji, M. Kim, H. Jung*, “Rapid implantation of dissolving microneedles on an electrospun pillar array”, Biomaterials, 2015, 64, 70

• M. Kim, H. Yang, H. Kim, H. Jung, H. Jung*, “Novel cosmetic patches for wrinkle improvement: retinyl retinoate- and ascorbic acid-loaded dissolving microneedles”, International Journal of Cosmetic Science, 2014, 36, 207

• S. G. Lee, J. H. Jeong, K. M. Lee, K. H. Jeong, H. Yang, M. Kim, H. Jung*, S. Lee, Y. W. Choi*, “Nanostructured lipid carrirer-loaded hyaluronic acid microneedles for controlled dermal delivery of a lipophilic molecule”, International Journal of Nanomedicine, 2013, 9, 289

• J. D. Kim, M. Kim, H. Yang, K. Lee, H. Jung*, “Droplet-born air blowing: Novel dissolving microneedle fabrication”, Journal of Controlled Release, 2013, 170, 430

Issued Patents

• KR 10-2198437, Shooting microstructures and applicator for the same, 2020

• KR 10-2186163, Microstructures patch for multi-function, 2020

• KR 10-2175312, Microstructure for transdermal delivery, 2020

• KR 10-2175310, Shooting microstructures and Applicator for the same , 2020

• CN ZL201780023330.4, Rotation assembler and centrifugal separator having the same, 2020

• KR 10-2174568, Stamp type microstructure applicator, 2019

• KR 10-2038751, Microneedle array with complex formulation and method for manufacturing the same, 2019

• EP 2995342, Method for manufacturinf mircostructure using centrifugal force and microstructure manufactured by same, 2019

• US 10441545, Microcellular microstructure and method for manufacturing same, 2019

• JP 6626221, Rotation assembler and centrifugal separator having the same, 2019

• JP 6622818, Microcellular microstructure and method for manufacturing same, 2019

• KR 10-1935378, Rotation assembler and apparatus for manufacturing microstructure having the same, 2018

• KR 10-1853308, Micro-room microstructure and method for fabricating thereof, 2018

• KR 10-1827739, Micro-room microstructure and method for fabricating thereof, 2018

• US 9943674, Microstructure-based drug delivery system comprising microporous structure, 2018

• US 9974936, Method for manufacturing microstructure using negative pressure and microstructure manufactured thereor, 2018

• CN ZL201480025446.8, Method for manufacturinf mircostructure using centrifugal force and microstructure manufactured by same, 2018

• US 10245423, Method for manufacturinf mircostructure using centrifugal force and microstructure manufactured by same, 2018

• KR 10-1703312, Microstructure-based drug delivery systems comprising microporous Structure , 2017

• KR 10-1754309, Methods for preparing microstructures using centrifugal force and microstructures prepared by the same, 2017

• KR 10-1808066, Microstructure and method for fabricatinf thereof using liquefaction of solid, 2017

• JP 6110562, Method for manufacturinf mircostructure using centrifugal force and microstructure manufactured by same, 2017

• KR 10-1590172, Methods for preparing microstructures using centrifugal force and microstructures prepared by the same, 2016

• KR 10-1488397, process for preparing microstructures by negative pressure and microstructures prepared by the same, 2015

Awards

• Excellent Poster Presentation Award, 2017 The Korean Society for Biotechnology and Bioengineering

• Best Research Award, 2017 Yonsei Brain Korea 21 PLUS

• Best Research Award, 2016 Yonsei Brain Korea 21 PLUS

• Excellent Prototype Award, 2015 Yonsei Tech Fair

• Excellent Technology Transfer and Industrialization Technology Development Award, 2015 Yonsei Brain Korea 21 PLUS