PUBLICATIONS
1. Tsai HC, Liao HT, Chen WS, Lai CC, Sun YS, Hsu TS*, Chen MH*. Reduced Deltex1 expression in T cells indicates increased disease activity in Sjögren's disease. Clin Exp Rheumatol. 2024 Dec 11. doi: 10.55563/clinexprheumatol/rtj93o. Epub ahead of print. PMID: 39661563. (Corresponding authors)
2. Tzeng YT, Chu PY, Yong SB, Hsu TS, Tseng LM, Hou MF, Sheu JJ, Hsiao JH, Li CJ. Multi-omic profiling of breast tumor microenvironment uncovers a role of mitochondrial calcium gatekeepers. J Cancer. 2024 May 13;15(12):3663-3674. doi: 10.7150/jca.95979. PMID: 38911376; PMCID: PMC11190767.
3. Tzeng YT, Chu PY, Yong SB, Hsu TS, Tseng LM, Hou MF, Sheu JJ, Hsiao JH, Li CJ. Spatial and Single-Cell Investigations Illuminate Theragnostic value and Immune Landscape of Mitochondrial Dynamin-Like GTPase in Breast Cancer. J Cancer. 2024 May 13;15(12):3633-3644. doi: 10.7150/jca.96100. PMID: 38911373; PMCID: PMC11190754.
4. Li CJ, Tzeng YT, Hsiao JH, Tseng LM, Hsu TS, Chu PY. Spatial and single-cell explorations uncover prognostic significance and immunological functions of mitochondrial calcium uniporter in breast cancer. Cancer Cell Int. 2024 Apr 17;24(1):140. doi: 10.1186/s12935-024-03327-z. PMID: 38632642; PMCID: PMC11022417.
5. Su YC, Phan TTT, Wang TW, Chang SH, Lin FH, Hsu TS*, Lin LY*. (2023) Nanoscaled biphasic calcium phosphate modulates osteogenesis and attenuates LPS-induced inflammation. Front. Bioeng. Biotechnol. 11:1236429. (Corresponding authors)
6. Phan TTT, Truong NV, Wu WG, Su YC, Hsu TS*, Lin LY*. (2023) Tumor suppressor p53 mediates interleukin-6 expression to enable cancer cell evasion of genotoxic stress. Cell Death Discov. Sep 11;9(1):340. (Corresponding authors)
7. Truong NV, Phan TTT, Hsu TS, Phu Duc P, Lin LY, Wu WG. (2023) Action mechanism of snake venom l-amino acid oxidase and its double-edged sword effect on cancer treatment: Role of pannexin 1-mediated interleukin-6 expression. Redox Biol. Aug;64:102791.
8. Hsu TS, Lin YL, Wang YA, Mo ST, Chi PY, Lai CY Alan, Pan HY, Chang YJ and Lai MZ. (2020) Hypoxia-inducible factor 2α is indispensable for regulatory T cell function. Nat Commun. Oct 6;11(1):5005.
9. Leu CM, Hsu TS, Kuo YP, Lai MZ, Liu PC, Chen MH, Chang DM, Tsai CY and Chen MH. (2019) Deltex1 suppresses T cell function and is a biomarker for diagnosis and disease activity of systemic lupus erythematosus. Rheumatology (Oxford) Apr 1;58(4):719-728.
10. Hsu TS and Lai MZ. (2018) Hypoxia-inducible factor 1α plays a predominantly negative role in regulatory T cell functions. J Leukoc Biol. Nov;104(5):911-918.
11. Hsieh WC, Hsu TS, Chang YJ, Lai MZ. (2018) IL-6 receptor blockade corrects defects of XIAP-deficient regulatory T cells. Nat Commun. Jan 31;9(1):463.
12. Hsu TS, Mo ST, Hsu PN, Lai MZ. (2018) c-FLIP is targeted by the E3 ligase deltex1 in gastric cancer. Cell Death Dis. Jan 26;9(2):135.
13. Chou TF, Chuang YT, Hsieh WC, Chang PY, Liu HY, Mo ST, Hsu TS, Miaw SC, Chen RH, Kimchi A, Lai MZ (2016) Tumour suppressor death-associated protein kinase targets cytoplasmic HIF-1α for Th17 suppression. Nat Commun. Jun 17; 7:11904.
14. *Hsiao HW, *Hsu TS, Liu WH, Hsieh WC, Chou TF, Wu YJ, Jiang ST, Lai MZ (2015) Deltex1 antagonizes HIF-1α
and sustains the stability of regulatory T cells in vivo. Nat Commun. Feb 19;6:6353. (*Co-first author)
15. Hsu TS, Hsiao HW, Wu PJ, Liu WH, Lai MZ (2014) Deltex1 promotes protein kinase Cθ degradation and sustains
Casitas B-lineage lymphoma expression. J Immunol. Aug 15;193(4):1672-80. (Doctoral dissertation)
16. Tsai CC, Liu HF, Hsu KC, Yang JM, Chen C, Liu KK, Hsu TS, and Chao JI (2011) 7-Chloro-6-piperidin-1-yl-
quinoline-5,8-dione (PT-262), a novel ROCK inhibitor blocks cytoskeleton function and cell migration. Biochem
Pharmacol. Apr 1;81(7):856-65.
17. Chiu SJ, Lee YJ, Hsu TS, Chen WS (2009) Oxaliplatin-induced gamma-H2AX activation via both p53-dependent
and -independent pathways but is not associated with cell cycle arrest in human colorectal cancer cells. Chem Biol Interact. Dec 10;182(2-3):173-82.
18. *Lin MH, *Hsu TS, Yang PM, Tsai MY, Perng TP, Lin LY (2009) Comparison of organic and inorganic germanium
compounds in cellular radiosensitivity and preparation of germanium nanoparticles as a radiosensitizer. Int J Radiat Biol. Mar;85(3):214-26. (*Co-first author)
19. Hsu TS, Yang PM, Tsai JS, Lin LY (2009) Attenuation of cadmium-induced necrotic cell death by necrostatin-1: potential necrostatin-1 acting sites. Toxicol Appl Pharmacol. Mar 1;235(2):153-62.
20. Hsu TS, Chen C, Lee PT, Chiu SJ, Liu HF, and Chao JI* (2008) 7-Chloro-6-piperidin-1-yl-quinoline-5,8-dione (PT-262), a novel synthetic compound induces lung carcinoma cell death associated with inhibiting ERK and CDC2 phosphorylation via a p53-independent pathway. Cancer Chemother Pharmacol. Oct;62(5):809.
21. Chiu SJ, Chao JI, Lin YJ, and Hsu TS (2008) Regulation of gamma-H2AX and securin contribute to apoptosis by oxaliplatin via a p38 mitogen-activated protein kinase-dependent pathway in human colorectal cancer cells. Toxicol Lett. Jun 30;179(2):63-70.
22. Chiu SJ, Hsu TS, and Chao JI (2007) Expression of securin promotes colorectal cancer cell death via a p53-independent pathway after radiation. Chem Biol Interact. Dec 15;170(3):153-61.
23. Chiu SJ, Hsu TS, and Chao JI (2006) Opposing securin and p53 protein expression in the oxaliplatin-induced cytotoxicity of human colorectal cancer cells. Toxicol Lett. Dec 1;167(2):122-30.
24. Chao, JI, Kuo, PC, and Hsu TS (2004) Down-regulation of survivin in nitric oxide-induced cell growth inhibition and apoptosis of the human lung carcinoma cells. J Biol Chem. May 7;279(19):20267-76.
CONFERENCE
1. PM Yang, Hsu TS, SJ Chiu (2006, Mar) Germanium oxide enhances radiosensivity via p53-independent pathways in human colorectal cancercells. Poster presentation at The 21st Joint Annual Conference of Biomedical Sciences, Taipei, Taiwan.
2. Hsu TS, PM Yang, LY Lin (2008, Mar) Necrostatin-1 attenuates necrotic cell death through activation of mitochondrial membrane potential and NF-κB activity. Poster presentation at The 23rd Joint Annual Conference of Biomedical Sciences, Taipei, Taiwan.
3. Hsu TS, Hsiao HW, Wu PJ, Liu WH, Lai MZ (2012, Oct) Ubiquitin E3 ligase deltex1 contributes to PKCθ degradation for full T cell anergy and immune tolerance. Oral presentation at The Chinese Society of Immunology Annual Meeting, Taipei, Taiwan.
4. Hsu TS, Hsiao HW, Wu PJ, Liu WH, Lai MZ (2014, Mar) Deltex1 promotes PKCθ degradation and increases Cbl-b expression. Poster presentation at The Ninth International Congress on Autoimmunity, Nice, France.
5. Hsu TS, Hsiao HW, Lai MZ (2019, Jan) Deltex1 regulates Foxp3 and regulatory T cell stability by antagonizing HIF-1α. Oral presentation at The Third Midwinter Conference (MWC) ‘Advances in Immunobiology’, Seefeld in Tirol, Austria.
PATENTS
1. 趙瑞益、徐子勝、陳清漂、李珮亭、邱淑君。化合物在製備治療肺癌、乳腺癌及子宮頸癌之藥物用途(中華民國專利證書發明第I359018號, 專利權有效期間2012/3/1~2026/7/13)
2. Chao JI, Hsu TS, Chen C, Lee PT, and Chiu SJ. Compound capable of cytoskeleton and induction of cell elongation and process for synthesizing the same. (US Publication No. US 2008/0015221 A1)