Publications

2023

Zhongxiao Fu, Mallikarjunarao Ganesana, Philip Hwang, Xiao Tan, Hong-Ru Chen, Melissa Marie Kinkaid, Emily Bian, Ogochukwu Uweru, Katia Sol-Church, Ukpong B. Eyo, Pankaj Kumar, Francisco J. Quintana, B. Jill Venton, Anne Schaefer, Chia Yi Kuan (2024). Microglia modulate cerebral blood flow and neurovascular coupling through ectonucleotidase CD39. Submmited

Naidi Sun*, Yu-Yo Sun*, Rui Cao, Hong-Ru Chen, Yiming Wang, Elizabeth Fugate, Marchelle R. Smucker, Yi-Min Kuo, P. Ellen Grant, Diana M. Lindquist, Chia-Yi Kuan, Song Hu (2024). Dual-modal metabolic analysis reveals a hypothermia-reversible uncoupling of oxidative phosphorylation in the hypoxic-ischemic neonatal brain. Submmited


Zhenfeng Song*, Kuang-Wei Wang*, Hsiao-Tien Chien Hagar*, Hong-Ru Chen, Chia-Yi Kuan, Kezhong Zhang, and Min-Hao Kuo (2023)

P-tau Inflicts Intracellular Stress Responses That Are Mitigated by Apomorphine. Molecular Neurobiology, DOI: 10.1007/s12035-023-03689-x (IF: 5.686)


Zhenfeng Song*, Kuang-Wei Wang*, Hsiao-Tien Chien Hagar*, Hong-Ru Chen, Chia-Yi Kuan, Kezhong Zhang, and Min-Hao Kuo (2023) Hyperphosphorylated tau Inflicts Intracellular Stress Responses That Are Mitigated by Apomorphine. bioRxiv, doi: https://doi.org/10.1101/2023.05.13.540661.


Hong-Ru Chen, Ton DeGrauw, Chia-Yi Kuan (2023, Feb) (Phospho)creatine: The Reserve and Merry-Go-Round of Brain Energetics. Neural Regeneration Research, 18 (2) 327-328 (IF: 6.058) 


2022

Yu-Yo Sun, Hui-Wen Yao. Hong-Ru Chen, Ching-Wen Chen, Melissa M Kinkaid, Chia-Yi Kuan (2022, Sep) Stroke Propensity in a Mouse Model of b-Thalassemia Intermedia. Neurobiology of Disease, 171, 105802 (IF: 7.046)              

Hong-Ru Chen, Ching-Wen Chen, Yi-Min Kuo, Brandon Chen, Irena S. Kuan, Henry Huang, Jolly Lee, Neil Anthony, Chia-Yi Kuan, Yu-Yo Sun (2022, Jan). Monocytes promote acute neuroinflammation and become pathological microglia in neonatal hypoxic-ischemic brain injury. Theranostics, https://www.thno.org/v12p0512.htm (IF: 11.6) 


2021

Kanchan Bisht1, Kenneth A. Okojie, Kaushik Sharma, Dennis H. Lentferink, Yu-Yo Sun, Hong-Ru Chen, Joseph O. Uweru, Saipranusha Amancherla, Zainab, Calcuttawala, Antony Brayan Campos Salazar, Bruce Corliss, Lara Jabbour, Jordan Benderoth, Bria Friestad, William A. Mills III, Brant Isakson, Marie-Ève Tremblay, Chia-Yi Kuan and Ukpong B. Eyo (2021, Aug). Capillary-associated microglia regulate vascular structure and function. Nature communications, https://doi.org/10.1038/s41467-021-25590-8 (IF: 17.694) 


Hong-Ru Chen, Xiaohui Zhang-Brotzge, Yury M Morozov, Yuancheng Li, Siming Wang, Helen Zhang, Irena S Kuan, Elizabeth M Fugate, Hui Mao, Yu-Yo Sun, Pasko Rakic, Diana M Lindquist, Ton DeGrauw, Chia-Yi Kuan (2021, July). Creatine transporter deficiency impairs stress-adaptation and brain energetics homeostasis. JCI Insight, https://doi.org/10.1172/jci.insight.140173 (IF: 9.484) 


Naidi Sun, Yu-Yo Sun, Rui Cao, Hong-Ru Chen, Yiming Wang, Elizabeth Fugate, Marchelle R Smucker, Yi-Min Kuo, P Ellen Grant, Diana M Lindquist, Chia-Yi Kuan, Song Hu (2021, Jan). Hypothermia Suppresses Uncoupling of Oxidative-Phosphorylation after Neonatal Cerebral Hypoxia-Ischemia. bioRxiv, https://doi.org/10.1101/2021.11.29.470404 


2020

Hong-Ru Chen, Ching-Wen Chen, Nandita Mandhani, Jonah C Short-Miller, Marchelle R Smucker, Yu-Yo Sun, Chia-Yi Kuan (2020, Dec). Monocytic Infiltrates Contribute to Autistic-like Behaviors in a Two-Hit Model of Neurodevelopmental Defects. Journal of Neuroscience, 40 (49) 9386-9400 (IF: 6.709)


Chia-Yi Kuan, Hong-Ru Chen, Ning Gao, Yi-Min Kuo, Ching-Wen Chen, Dianer Yang, Melissa M Kinkaid, Erding Hu, Yu-Yo Sun (2020, Nov). Brain targeted hypoxia-inducible factor stabilization reduces neonatal hypoxic ischemic brain injury. Neurobiology of Disease, 148:105200 (IF: 7.046)


Hong-Ru Chen, Yu-Yo Sun, Ching-Wen Chen, Yi-Min Kuo, Irena S Kuan, Zheng-Rong Tiger Li, Jonah C Short-Miller, Marchelle R Smucker, Chia-Yi Kuan (2020, Aug). Fate mapping via CCR2-CreER mice reveals monocyte-to microglia transition in development and neonatal stroke. Science Advances, DOI:10.1126/sciadv.abb2119 (IF: 14.980) 


Yu-Yo Sun*, Yi-Min Kuo*, Hong-Ru Chen, Jonah C Short-Miller, Marchelle R Smucker, Chia-Yi Kuan (2020, Apr). A murine photothrombotic stroke model with an increased fibrin content and improved responses to tPA-lytic treatment. Blood Advances, 4(7): 1222–1231 (IF: 7.642) 


2017

Hong-Ru Chen, Hsien-Chia Juan, Yu-Hui Wong, Jin-Wu Tsai, Ming-Ji Fann (2017, Mar). Cdk12 Regulates Neurogenesis and Late-Arising Neuronal Migration in the Developing Cerebral Cortex. Cerebral Cortex, 27(3): 2289–2302 (IF: 5.357) 


2016

Hsien-Chia Juan, Yong Lin, Hong-Ru Chen, Ming-Ji Fann (2016, Jun). Cdk12 is essential for embryonic development and the maintenance of genomic stability. Cell Death and Differentiation, 23, 1038–1048 (IF: 12.073)


2014

Hong-Ru Chen, Guan-Ting Lin, Chun-Kai Huang, Ming-Ji Fann (2014, Nov). Cdk12 and Cdk13 regulate axonal elongation through a common signaling pathway that modulates Cdk5 expression. Experimental Neurology, 261: 10-21 (IF: 5.620) 


2011

Hong-Ru Chen, Hung-Chi Yang, Dennis Jine-Yuan Hsieh, Zijuan Liu, Kan-Jen Tsai (2011, Feb). Zebrafish sod1 and sp1 expression are modulated by the copper ATPase gene atp7a in response to intracellular copper status. Chemico-Biological Interactions, 189 (3) 192-197 (IF: 5.168) 

Conference Presentations


2022 

Chen, H. R., Zhang-Brotzge, X., Morozov, Y. M., Li, Y., Wang, S., Zhang, H. H., Kuan, I. S. , Fugate, E. M., Mao, H., Sun, Y. Y., Rakic, P., Lindquist, D. M., DeGrauw, T., Kuan, C. Y. Creatine transporter deficiency impairs stress adaptation and brain energetics homeostasis. (CCDS Symposium, featured speaker, Utah, USA, 2022)


Chen, H. R., Zhang-Brotzge, X., Morozov, Y. M., Li, Y., Wang, S., Zhang, H. H., Kuan, I. S. , Fugate, E. M., Mao, H., Sun, Y. Y., Rakic, P., Lindquist, D. M., DeGrauw, T., Kuan, C. Y. Creatine transporter deficiency impairs stress adaptation and brain energetics homeostasis. (Gastro-Hepato Congress, distinguished speaker, Paris, France, 2022)


Li, R.C., Medernach, J., Etter, E., Borish, L., Chen, H. R., Wilson, J., Barnes, B., Platts-Mills, T., Sauer, B., McGowan, E. Co-localization of Immunoglobulin G4 (IgG4) and milk proteins is associated with EoE disease activity (American Academy of Allergy, Asthma & Immunology, USA, 2022)


2020     

Chen, H. R., Chen, C. W., Sun, Y. Y., Kuan, C. Y. Monocyte-to-microglia transition in development and neonatal stroke revealed by CCR2CreER mice (CSHL Glia in Health & Disease, poster, #236, USA, 2020)


2019

Chen, H. R., Sun, Y. Y., Kuan, C. Y. CCR2CreER mice for fate mapping monocytes during brain development and after ischemic stroke (The 49th Annual Conference of Neuroscience, poster, USA, 2019)


Chen, H. R., Sun, Y. Y., Kuan, C. Y. CCR2CreER mice for fate mapping monocytes during brain development and after ischemic stroke (Angiogenesis Gordon Research Conference, oral presentation and poster, USA, 2019)


Chen, H. R., Zhang-Brotzge, X. Z., DeGrauw, T. J., I., Lindquist, D., Wang, S., Sun, Y.Y., Kuan, C. Y. Creatine Transporter (CrT) Deficiency Impairs Brain Energetics Under Stress (Central Virginia Chapter of the Society for Neuroscience, poster, USA, 2019)


Chen, H. R., Mandhani, N., Chen, C. W., Sun, Y. Y., Kuan, C. Y. Monocytes as an Ectopic Source of Otx2 in Perineuronal Nets (PNNs) and Autism (University of Virginia Immunology Research Day, oral presentation, USA, 2019)


Chen, H. R., Sun, Y. Y., Kuan, C. Y. CCR2CreER mice for fate mapping monocytes during brain development and after ischemic stroke. Neuroimmune Communication in Health and Disease (GRS & GRC, poster, USA, 2019)


2018

Chen, H. R., Zhang-Brotzge, X. Z., DeGrauw, T. J., I., Lindquist, D., Wang, S., Sun, Y.Y., Kuan, C. Y. Creatine Transporter (CrT) Deficiency Impairs Brain Energetics Under Stress. (20th European Bioenergetics Conference (EBEC), poster, Hungary, 2018) https://doi.org/10.1016/j.bbabio.2018.09.222


Chen, H. R., Mandhani, N., Sun, Y. Y., Kuan, C. Y. Maternal immune activation sensitizes the neonatal immune responses to neonatal hypoxia-ischemia in offspring brains (Central Virginia Chapter of the Society for Neuroscience, poster, USA, 2018)


Kuan, C. Y., Chen, H. R. Prenatal Maternal Immune Activation Sensitizes the Neuroinflammatory Responses to Neonatal Hypoxic-Ischemic Brain Injury (The American Association of Immunologists, USA, 2018) https://www.jimmunol.org/content/200/1_Supplement/166.58/tab-article-info


2016

Chen, H. R., Juan, H. C., Wong, Y. H., Tsai, J. W., Fann, M. J. Cdk12 Regulates Neurogenesis and Late-Arising Neuronal Migration in the Developing Cerebral Cortex (The 46th Annual Conference of Neuroscience, poster, USA, 2016)


Chen, H. R., Huang, H., Chen, S., Lee, J., Sun, Y. Y., Rakic, P., Kuan, C. Y. Glast positive radial glia produce potnatal SVZ/RMS, but not prenatal neurons (Southern pediatric research innovation conference, poster, Atlanta, USA, 2016)

 

2015

Chen, H. R., Juan, H. C., Wong, Y. H., Tsai, J. W., and Fann, M. J. Cdk12 regulates neurogenesis and late-arising neuronal migration in the developing cerebral cortex. (International Conference on Stem Cells and Developmental Biology, oral presentation and poster (Session Number: 59), Taiwan, 2015)


2013

Chen, H. R. and Fann, M. J. Functions of Cdk12 and Cdk13 in axonal growth and neural development. (Israel-Taiwan Young Life Scientists Conference, poster (Session Number: P12), Taiwan, 2013)


Chen, H. R. and Fann, M. J. Cdk12 regulates neurogenesis and late-arising neuronal migration in the developing cerebral cortex. (The 43th Annual Conference of Neuroscience, poster (Session Number: 609), USA, 2013)


Chen, H. R. and Fann, M. J. Cdk12 and Cdk13 in axonal growth and neural development. (40th Annual Meeting of Taiwan Neuroscience Society, poster (Session Number: P6), 2013)


2012

Chen, H. R., Lin, G. T., Huang, C. K., and Fann, M. J. Cdk12 and Cdk13 regulate axonal elongation through a common signaling pathway that modulates Cdk5 expression. (The Asia-Pacific Developmental Biology Conference (APDBC), poster, Taiwan, 2012)


2010

Chen, H. R., Lin, G. T., and Fann, M. J. Cdk12 and Cdk13 regulate axonal elongation through a common signaling pathway that modulates Cdk5 expression. (The 40th Annual Conference of Neuroscience, poster (Session Number: 333), USA, 2010)


Chen, H. R. and Fann, M. J. Cdk12 and Cdk13 regulate axonal elongation through a common signaling pathway that modulates Cdk5 expression. (The Developmental Biology Retreat, poster, Taiwan, 2010)


2009

Chen, H. R. and Tsai, K. J. Zebrafish sod1 and sp1 expression are modulated by the copper ATPase gene atp7a in response to intracellular copper status. (The 24th Joint Annual Conference of Biomedical Science, poster (Session Number: P575), Taiwan, 2009)

† Invited talks (within five years):

#1 2023 The Center for Neuropsychiatric Research at National Health Research Institutes, invited speaker

#2 2023 The Neuroscience Society of Taiwan, invited speaker

Title: Monocyte activation and neurotoxicity of hyperphosphorylated tau oligomers

#3 2023 TIGP-INS (Interdisciplinary Neuroscience) Retreat, Taiwan, invited speaker

Title: Monocyte to Microglia Transition in Development and Neonatal Brain Injury

#4 2022 TIGP-MM & MMP Joint Retreat, Taiwan, invited speaker

Title: Monocyte to Microglia Transition in Neonatal Brain Injury

#5 2022 Brain Research Center, NYCU, BRC, Taiwan, invited speaker

Title: Assessing the neurotoxicity of hyperphosphorylated human Tau oligomers in mouse brains

#6 2022 生科有約, NYCU, Taiwan, invited speaker

Title: Two Vignettes: Monocyte-to-Microglia Transition in Neonatal Brain Injury and Neurotoxicity of Hyperphosphorylated Tau Oligomers in Neurodegenerative Disorder

#7 2022 CCDS Symposium, featured speaker, Utah, USA

Title: Creatine transporter deficiency impairs stress adaptation and brain energetics homeostasis.

#8 2022 Gastro-Hepato Congress, distinguished speaker, Paris, France

Title: Creatine transporter deficiency impairs stress adaptation and brain energetics homeostasis.

#9 2019 Angiogenesis Gordon Research Conference, oral presentation, USA

Title: CCR2CreER mice for fate mapping monocytes during brain development and after ischemic stroke

#10 2019 University of Virginia Immunology Research Day, oral presentation, USA

Title: Monocytes as an Ectopic Source of Otx2 in Perineuronal Nets (PNNs) and Autism