Publications

2024

•  Park, H., Kam, T. I., Dawson, V. L., & Dawson, T. M. (2024). α-Synuclein pathology as a target in neurodegenerative diseases. Nature Reviews Neurology, 1-16. (IF: 43.8)

2023

•  Kim Y, Park H, Kim Y, Kim SH, Lee JH, Yang H, Kim SJ, Li CM, Lee H, Na DH, Moon S, Shin Y, Kam TI, Lee HW, Kim S, Song JJ, Jung YK. (2022) Pathogenic Role of RAGE in Tau     Transmission and Memory Deficits. Biological Psychiatry.  S0006-3223(22): 01707-3. (IF: 12.810)

2022

•  Park H*, Kam TI*, Peng H, Chou SC, Mehrabani-Tabar AA, Song JJ, Yin X, Karuppagounder SS, Umanah GK, Rao S, Choi Y, Aggarwal A, Chang S, Kim H, Byun J, Liu JO, Dawson TM,              Dawson VL (2022) PAAN/MIF Nuclease Inhibition Prevents Neurodegeneration in Parkinson’s Disease. Cell. 185(11):1943-1959.e21 (*Co-first) (IF:66.85) 

•  Kam TI, Park H, Chou SC, Vranken JGV, Mittenbühler MJ, Kim H, A M, Choi YR, Biswas D, Wang J, Shin Y, Loder A, Karuppagounder SS, Wrann CD, Dawson VL, Spiegelman BM, 

   Dawson TM. (2022) Amelioration of pathologic α-synuclein-induced Parkinson’s disease by irisin. PNAS. 119(36): e2204835119 (IF:12.777)   

•  Sterling JK*, Kam TI*, Guttha S, Park H,  Baumann B, Mehrabani-Tabari AA, Schultz H, Anderson B, Alnemri A, Chou SC, Troncoso JC, Dawson VL, Dawson TM, Dunaief J. (2022) 

   Interleukin-6 triggers toxic neuronal iron sequestration in  response to pathological α-synuclein. Cell Reports. 38(7):110358 (IF:9.995) 

2021

•  Seo BA, Kim D, Hwang H, Kim MS, Ma SX, Kwon SH, Kweon SH, Wang H, Yoo JM, Choi S, Kwon SH, Kang SU, Kam TI, Kim K, Karuppagounder SS, Kang BG, Lee S, Park H, Kim S, 

   Yan W, Li YS, Kuo SH, Redding-Ochoa J, Pletnikova O, Troncoso JC, Lee G, Mao X, Dawson VL, Dawson TM, Ko HS. (2021) TRIP12 ubiquitination of glucocerebrosidase contributes to              neurodegeneration in Parkinson's disease. Neuron. 109(23):3758-3774.e11 (IF: 18.688) 

•  Jo A*, Lee Y*, Kam TI*, Kang SU, Neifert S, Karuppagounder SS, Khang R, Kang H, Park H, Chou SC, Oh S, Jian H, Swing DA, Ham S, Pirooznia S, Umanah GKE, Mao X, Kumar M, Ko HS,     Kang HC, Lee BD, Lee YI, Andrabi SA, Park CH, Lee JY, Kim H, Kim H, Kim H, Cho JW, Paek SH, Na CH, Tessarollo L, Dawson VL, Dawson TM, Shin JH. (2021) 

    PARIS farnesylation prevents neurodegeneration in models of Parkinson’s disease. Science Translational Medicine. 28;13(604):eaax8891 (IF:19.319)

•  Zhang L, Chen C, Fu J, Lilley B, Berlinicke C, Hansen B, Ding D, Wang G, Wang T, Shou D, Ye Y, Mulligan T, Emmerich K, Saxena MT, Hall KR, Sharrock AV, Brandon C, 

   Park H, Kam TI, Dawson VL, Dawson TM, Shim JS, Hanes J, Ji H, Liu JO, Qian J, Ackerley DF, Rohrer B, Zack DJ, Mumm JS. (2021) Large-scale phenotypic drug screen 

   identifies neuroprotectants in zebrafish and mouse models of retinitis pigmentosa. Elife 29;10:e57245. doi: 10.7554/eLife.57245 (IF: 8.140)

•  Park JS*, Kam TI*, Lee S, Park H, Oh Y, Kwon SH, Song JJ, Kim D, Kim H, Jhaldiyal A, Na DH, Lee KC, Park EJ, Pomper MG, Pletnikova O, Troncoso JC, Ko HS, 

   Dawson VL, Dawson TM, Lee S. (2021) Blocking microglial activation of reactive astrocytes is neuroprotective in models of Alzheimer's disease. 

   Acta Neuropathologica Communications. 9:78. doi: 10.1186/s40478-021-01180-z (IF:7.578)

2020

•  Park H, Kam TI, Dawson TM, Dawson VL. (2020) Poly (ADP-ribose) (PAR)-dependent cell death in neuro-degenerative diseases. 

   International Review of Cell and Molecular Biology. 353, 1-29. (IF:6.42)  

2018

•  Kam TI*, Mao X*, Park H*, Chou SC, Karuppagounder SS, Umanah GE, Yun SP, Brahmarchari S, Panicker N, Chen R,  Andrabi SA, Qi C, Poirier GG, Pletnikova O, Troncoso JC, Bekris LM,       Leverenz JB, Pantelyat A, Ko HS, Rosenthal LS, Dawson TM, Dawson VL. (2018) Poly (ADP-ribose) drives pathologic a-synuclein neurodegeneration in Parkinson’s disease. 

   Science 362(6414), doi: 10.1126/science. aat8407 (*Co-first) (IF: 63.714) 

•  Yun SP*, Kam TI*, Panicker N, Kim S, Oh Y, Park JS, Kwon SH, Park YJ, Karuppagounder SS, Park H, Kim S, Oh N, Kim NA, Lee S, Brahmachari S, Mao X, Lee JH, Kumar M, An D, 

   Kang SU, Lee Y, Lee KC, Na DH, Kim D, Lee SH, Roschke V, Liddelow SA, Mari Z, Barres BA, Dawson VL, Lee S, Dawson TM, Ko HS (2018)

   Block of A1 astrocyte conversion by microglia is neuroprotective in models of Parkinson’s disease. Nature Medicine 24(7), 931-938 (IF: 87.241) 

•  Gwon Y*, Kam TI*, Kim SH, Song S, Park H, Lim B, Lee H, Lee W, Jo DG, Jung YK(2018) TOM1 regulates neuronal accumulation of amyloid-β oligomers by FcγRIIb2 variant 

    in Alzheimer’s disease. Journal of Neuroscience pii:1996-17 (IF: 6.709) 

2016

•  Kam TI*, Park H*, Gwon Y*, Song S, Kim SH, Moon SW, Jo DG, Jung YK. (2016) FcγRIIb-SHIP2 axis links Aβ to tau pathology by disrupting phosphoinositide metabolism in Alzheimer's              disease model. Elife pii:e18691 (*Co-first) (IF: 8.140)

•  Wang Y, An R, Umanah GK, Park H, Nambiar K, Eacker SM, Kim B, Bao L, Harraz MM, Chang C, Chen R, Wang JE, Kam TI, Jeong JS, Xie Z, Neifert S, Qian J, Andrabi SA, Blackshaw S,           Zhu H, Song H, Ming GL, Dawson VL, Dawson TM. (2016) A nuclease that mediates cell death induced by DNA damage and poly(ADP-ribose) polymerase-1. 

   Science 354(6308) (IF: 63.714)

•  Mao X, Ou MT, Karuppagounder SS, Kam TI, Yin X, Xiong Y, Ge P, Umanah GE, Brahmachari S, Shin JH, Kang HC, Zhang J, Xu J, Chen R, Park H, Andrabi SA, Kang SU, 

   Gonçalves RA, Liang Y, Zhang S, Qi C, Lam S, Keiler JA, Tyson J,  Kim D, Panicker N, Yun SP, Workman CJ, Vignali DA, Dawson VL, Ko HS, Dawson TM. (2016) 

   Pathological α-synuclein transmission initiated by binding lymphocyte-activation gene 3. Science 353(6307). (IF: 63.714)

•  Kim Y, Choi H, Lee W, Park H, Kam TI, Hong SH, Nah J, Jung S, Shin B, Lee H, Choi TY, Choo H, Kim KK, Choi SY, Kayed R, Jung YK. (2016) 

   Caspase-cleaved tau exhibits rapid memory impairment associated with tau oligomers in a transgenic mouse model. Neurobiology of Disease 87,19-28. (IF: 7.046) 

2015

•  Choi S, Kim D, Kam TI, Yun S, Kim S, Park H, Hwang H, Pletnikova O, Troncoso JC, Dawson VL, Dawson TM, Ko HS. (2015) 

    Lysosomal Enzyme Glucocerebrosidase Protects against Aβ1-42 Oligomer-Induced Neurotoxicity. PLoS One 10(12) (IF: 3.752)

•  Kim Y, Park H, Nah J, Moon S, Lee W, Hong SH, Kam TI, Jung YK. (2015) Essential role of POLDIP2 in Tau aggregation and neurotoxicity via autophagy/proteasome inhibition. 

   Biochem Biophys Res Commun. 462(2), 112-118. (IF: 3.321)

2013

•  Kam TI*, Song S*, Gwon Y, Park H, Yan JJ, Im I, Choi JW, Choi TY, Kim J, Song DK, Takai T, Kim YC, Kim KS, Choi SY, Choi S, Klein WL, Yuan J, and Jung YK. (2013) 

   FcγRIIb mediates amyloid-β neurotoxicity and memory impairment in Alzheimer’s disease. Journal of Clinical Investigation 123(7), 2791-2802 (*Co-first) (IF: 19.456)

2012

•  Park H, Kam TI, Kim Y, Choi H, Gwon Y, Kim C, Koh JY, and Jung YK. (2012) Neuropathogenic role of adenylate kinase 1 in Aβ-mediated tau phosphorylation via AMPK and GSK3β. 

   Human Molecular Genetics 21(12), 2725-2737. (IF: 5.121)