Les Houches-TSRC Workshop on Protein Dynamics
Online workshop on May 18+19, 2021.
In-person meeting in Spring/Summer 2022 in the French Alps
This workshop is a forum for presenting, teaching and discussing results from the application of state-of-the-art experimental (including, but not limited to, optical spectroscopy, NMR spectroscopy, X-ray crystallography, XFELs, electron microscopy, AFM and scattering methods), and theoretical and computational approaches to studying protein dynamics.
The Les Houches – TSRC Protein Dynamics Workshop complements the long-standing TSRC Protein Dynamics Workshop, held every other year in the odd calendar years at the Telluride Science Research Center in Telluride, Colorado.
The workshop, originally planned in May 2020, was postponed to spring/summer 2022 and an online-version, to be held on May 18+19, 2021.
Online Workshop on May 18+19, 2021
Due to the special situation in 2020 and 2021, we have decided to bring the community together to exchange ideas and keep the spirit active. Thus, we are proud to have a great set of speakers for the 2021 online workshop.
Speakers: (click on title to see abstracts)
James Fraser: "Targeting COVID-19 Viral Enzymes in an Evolving Landscape of Publishing and Peer Review"
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) macrodomain within the nonstructural protein 3 counteracts host-mediated antiviral adenosine diphosphate-ribosylation signaling. This enzyme is a promising antiviral target because catalytic mutations render viruses nonpathogenic. We conducted a massive crystallographic screening and computational docking effort, identifying new chemical matter primarily targeting the active site of the macrodomain. X-ray data collection to ultra-high resolution and at physiological temperature enabled assessment of the conformational heterogeneity around the active site. Neutron diffraction data is guiding hydrogen placement to improve docking calculations. Several hits have promising activity in solution and provide starting points for development of potent SARS-CoV-2 macrodomain inhibitors. The role of entropy in modulating binding affinity will also be discussed.
to be announced soon
Dorothee Kern: "Time travel to the past and future – evolution of energy landscapes for enzymes catalysis"
Claus Seidel: "Integrative dynamic structural biology of proteins with multi-modal fluorescence spectroscopy "
to be announced soon
Information about our speakers:
"Poster-session" during online workshop.
We think that excellent science is stimulated by exchange - even in times of travel restrictions. Therefore, we plan to have a virtual poster session in virtual breakout rooms, and hopefully the same stimulating setting as the one we usually have. Except for the view on the mountains and the beer. The latter will be back in the 2022 version only (and we are looking forward to it!).
Enrica Bordignon (Ruhr University Bochum, Germany)
Matthias Heyden (Arizona State University, USA)
Paul Schanda (IBS, Grenoble, France / Institute of Science and Technology Austria)
Ben Schuler (University of Zurich, Switzerland)
Martin Weik (Institut de Biologie Structurale, Grenoble, France)
The Ecole de Physique des Houches is supported by: