Our research idea is based on "material tetrahedron" concept which signifies holistic relationship of material preparation with its characteristics and attributes which can lead to performance in the areas of healthcare and environmental applications. Overall the research in our group is structured around four interrelated research themes.
Theme 1: Engineered Carbon based nanostructure and their composites
Preparation of chiral engineered carbon-based nanostructures and composites through controlled surface functionalization, heteroatom doping, and supramolecular assembly to unlock enantiomeric dependent sensing and therapeutic delivery.
Theme 2: Nanotherapeutics
Enantiomeric-dependent nanotherapeutics harness the power of chirality i.e. the “handedness” of molecules to design smarter, more selective treatments. By engineering chirality into nanomaterials, we are creating therapies that interact differently with left- and right-handed biological molecules, leading to greater precision, improved efficacy, and reduced side effects. This approach opens exciting opportunities in personalized medicine, targeted drug delivery, and advanced nanomedicine.
Theme 3: Optical biosensing
By exploiting differences in circular dichroism, fluorescence, and plasmonic responses, these systems enable precise enantioselective detection of amino acids, proteins, drugs, and metabolites. Such technologies hold strong potential for early disease diagnostics, pharmaceutical quality control, and personalized healthcare.
Theme 4: In vitro & In vivo disease mimicked conditions
Enantiomeric-dependent studies under in vitro and in vivo disease-mimicked conditions provide critical insights into how chiral nanomaterials interact with complex biological environments. By simulating pathological states such as oxidative stress, inflammation, or tumor microenvironments, we can evaluate enantioselective responses in cellular uptake, biodistribution, therapeutic action, and biosafety. These studies bridge the gap between fundamental chirality-driven mechanisms and their translational potential in real-world disease models, paving the way for precision nanomedicine.
Chirality & Biological system: A mystique affair