Sunaga T, Miki S, Takahashi F, Aoshima K, Kim S, Okumura M. Progressive myelomalacia with spinal cord disorders along with severe intradural hemorrhage in a cat. J Vet Med Sci. 2025 Aug 1;87(8):954-959. doi: 10.1292/jvms.23-0493. Epub 2025 Jul 2. PMID: 40603069; PMCID: PMC12344301.
Sung K, Hosoya K, Deguchi T, Yamashita K, Kim S, Sunaga T, Yasui H, Inanami O, Okumura M. Glutathione-associated redox regulation alleviates radio-resistance of canine cancer stem-like cells with low proteasome activity. Sci Rep 15, 18017, 2025.
Owaki R, Hosoya K, Deguchi T, Konnai S, Maekawa N, Okagawa T, Yasui H, Kim S, Sunaga T, Okumura M. Enhancement of radio-sensitivity by inhibition of Janus kinase signaling with oclacitinib in canine tumor cell lines. Mol Ther Oncol 33, 200946, 2025.
Nakamura M, Matsumoto Y, Yasuda K, Nagata M, Nakaki R, Okumura M, Yamazaki J. Unraveling the DNA methylation landscape in dog blood across breeds. BMC Genomics 25,1089 2024.
Matsumoto S, Hosoya K, Kim S, Okumura M. Tensioning diaphragmoplasty for treating bilateral phrenic nerve paralysis in a dog. J Small Anim Pract 66, 424-431, 2025.
Nakamura M, Matsumoto Y, Yasuda K, Nagata M, Nakaki R, Okumura M, Yamazaki J. Unraveling the DNA methylation landscape in dog blood across breeds. BMC Genomics. 2024 Nov 15;25(1):1089. doi: 10.1186/s12864-024-10963-2. PMID: 39548380; PMCID: PMC11566899.
Mwale C, Sunaga T, Wang Y, Bwalya EC, H. M. Wijekoon S, Kim S, Okumura M. In vitro chondrotoxicity of bupivacaine at low concentrations in cultured canine articular chondrocytes. Jpn J Vet Res. 71(1): 1-11, 2023
Wang Y, Mwale C, Akaraphutiporn E, Kim S, Sunaga T, Okumura M, Sulfate level relied effects of pentosan polysulfate sodium on inhibiting the proliferation of canine articular chondrocytes by targeting PI3K/Akt pathway. Jpn J Vet Res. 71(2): 35-47. 2023
Wang Y, Sunaga T, Mwale C, Akaraphutiporn E, Kim S, Okumura M, Pentosan polysulfate sodium promotes redifferentiation to the original phenotype in micromass-cultured canine articular chondrocytes and exerts molecular weight-dependent effects. J Vet Med Sci. 85(6): 680-690, 2023
Owaki R, Deguchi T, Konnai S, Maekawa N, Okagawa T, Hosoya K, Kim S, Sunaga T, Okumura M.Regulation of programmed death ligand 1 expression by interferon-γ and tumour necrosis factor-α in canine tumour cell lines. Vet Comp Oncol. 21(2): 279-290. 2023
Mwale C, Sunaga T, Wang Y, Bwalya EC, Wijekoon S, Kim S, Okumura M. In vitro chondrotoxicity of bupivacaine, levobupivacaine and ropivacaine and their effects on caspase activity in cultured canine articular chondrocytes. J Vet Med Sci. 85(4):515-522, 2023
Wijekoon S, Tsogbadrakh M, Sunaga T, Wang Y, Mwale C, Kim S, Alimaa D, Okumura M. Pentosan polysulfate regulates hepcidin expression in native Mongolian horses. J Vet Med Sci. 2022 Oct 7;84(10):1437-1441. doi: 10.1292/jvms.22-0113. Epub 2022 Aug 30. PMID: 36047165; PMCID: PMC9586020.
Wijekoon S, Sunaga T, Wang Y, Mwale C, Kim S, Okumura M. Pentosan polysulfate regulates hepcidin 1-facilitated formation and function of osteoclast derived from canine bone marrow. PLoS One. 2022 Mar 17;17(3):e0265596. doi: 10.1371/journal.pone.0265596. PMID: 35299233; PMCID: PMC8929557.
Murase Y, Hosoya K, Sato T, Kim S, Okumura M. Antitumor activity of the dual PI3K/mTOR inhibitor gedatolisib and the involvement of ABCB1 in gedatolisib resistance in canine tumor cells. Oncol Rep. 2022 Apr;47(4):61. doi: 10.3892/or.2022.8272. Epub 2022 Jan 28. PMID: 35088890; PMCID: PMC8848474.
Sung K, Hosoya K, Murase Y, Deguchi T, Kim S, Sunaga T, Okumura M. Visualizing the cancer stem-like properties of canine tumour cells with low proteasome activity. Vet Comp Oncol. 2022 Mar;20(1):324-335. doi: 10.1111/vco.12779. Epub 2021 Nov 12. PMID: 34719098.
Akaraphutiporn E, Sunaga T, Bwalya EC, Yanlin W, Carol M, Okumura M. An Insight into the Role of Apoptosis and Autophagy in Nitric Oxide-Induced Articular Chondrocyte Cell Death. Cartilage. 2021 Dec;13(2_suppl):826S-838S. doi: 10.1177/1947603520976768. Epub 2020 Dec 14. PMID: 33307758; PMCID: PMC8804748.
Kim S, Hosoya K, Fukayama N, Deguchi T, Okumura M. Safety and efficacy of a nonmyeloablative pretransplant conditioning regimen using total lymphoid irradiation with volumetric modulated arc therapy in healthy dogs: A pilot study. Vet Med Sci. 2021 Jul;7(4):1120-1130. doi: 10.1002/vms3.470. Epub 2021 Mar 13. PMID: 33713574; PMCID: PMC8294366.
Takeuchi R, Takagi S, Hosoya K, Ohta H, Itami T, Okumura M. Postoperative improvement of megaesophagus and esophageal motility in a 19-day-old puppy with gastroesophageal intussusception. J Vet Med Sci. 2021 Nov 16;83(11):1740-1744. doi: 10.1292/jvms.21-0384. Epub 2021 Sep 21. PMID: 34544935; PMCID: PMC8636889.
Akaraphutiporn E, Sunaga T, Bwalya EC, Echigo R, Okumura M. Alterations in characteristics of canine articular chondrocytes in non-passaged long-term monolayer culture: Matter of differentiation, dedifferentiation and redifferentiation. J Vet Med Sci. 2020 Jun 24;82(6):793-803. doi: 10.1292/jvms.20-0118. Epub 2020 Apr 30. PMID: 32350166; PMCID: PMC7324834.
Akaraphutiporn E, Bwalya EC, Kim S, Sunaga T, Echigo R, Okumura M. Effects of pentosan polysulfate on cell proliferation, cell cycle progression and cyclin-dependent kinases expression in canine articular chondrocytes. J Vet Med Sci. 2020 Aug 28;82(8):1209-1218. doi: 10.1292/jvms.20-0091. Epub 2020 Jul 7. PMID: 32641601; PMCID: PMC7468060.
Kim S, Hosoya K, Takagi S, Okumura M. Outcomes following balloon dilation for management of urethral obstruction secondary to urothelial carcinoma in dogs: 12 cases (2010-2015). J Am Vet Med Assoc. 2019 Aug 1;255(3):330-335. doi: 10.2460/javma.255.3.330. PMID: 31298635.
Kim S, Hosoya K, Kobayashi A, Okumura M. Comparison of three mobilization protocols for peripheral blood stem cell apheresis with Spectra Optia continuous mononuclear cell protocol in healthy dogs. Vet Comp Oncol. 2019 Mar;17(1):61-68. doi: 10.1111/vco.12446. Epub 2018 Oct 11. PMID: 30221450.
Deguchi T, Hosoya K, Murase Y, Koangyong S, Kim S, Okumura M. Analysis of radiosensitivity of cancer stem-like cells derived from canine cancer cell lines. Vet Comp Oncol. 2019 Jun;17(2):119-129. doi: 10.1111/vco.12452. Epub 2019 Jan 20. PMID: 30549190.
Suranji Wijekoon HM, Kim S, Bwalya EC, Fang J, Aoshima K, Hosoya K, Okumura M. Anti-arthritic effect of pentosan polysulfate in rats with collagen-induced arthritis. Res Vet Sci. 2019 Feb;122:179-185. doi: 10.1016/j.rvsc.2018.11.028. Epub 2018 Dec 1. PMID: 30529273.
Wijekoon HMS, Bwalya EC, Fang J, Kim S, Hosoya K, Okumura M. Inhibitory effects of sodium pentosan polysulfate on formation and function of osteoclasts derived from canine bone marrow. BMC Vet Res. 2018 May 2;14(1):152. doi: 10.1186/s12917-018-1466-4. PMID: 29720166; PMCID: PMC5930774.
Takagi S, Kagawa Y, Hanazono K, Murakami S, Deguchi T, Izumi Y, Hosoya K, Kim S, Okumura M. Mandibular vascular hamartoma in a cat. J Vet Med Sci. 2018 Sep 26;80(9):1456-1458. doi: 10.1292/jvms.18-0148. Epub 2018 Jul 13. PMID: 30012929; PMCID: PMC6160891.
Bwalya EC, Wijekoon HS, Fang J, Kim S, Hosoya K, Okumura M. Independent chondrogenic potential of canine bone marrow-derived mesenchymal stem cells in monolayer expansion cultures decreases in a passage-dependent pattern. J Vet Med Sci. 2018 Nov 9;80(11):1681-1687. doi: 10.1292/jvms.18-0202. Epub 2018 Sep 11. PMID: 30210068; PMCID: PMC6261819.
Wijekoon S, Bwalya EC, Fang J, Kim S, Hosoya K, Okumura M. Chronological differential effects of pro-inflammatory cytokines on RANKL-induced osteoclast differentiation of canine bone marrow-derived macrophages. J Vet Med Sci. 2017 Dec 22;79(12):2030-2035. doi: 10.1292/jvms.17-0393. Epub 2017 Nov 3. PMID: 29109351; PMCID: PMC5745185.
Wijekoon HMS, Toyota K, Kim S, Fang J, Bwalya EC, Hosoya K, Okumura M. Differentiation potential of synoviocytes derived from joints with cranial cruciate ligament rupture and medial patella luxation in dogs. Res Vet Sci. 2017 Oct;114:370-377. doi: 10.1016/j.rvsc.2017.07.004. Epub 2017 Jul 9. PMID: 28711819.
Bwalya EC, Kim S, Fang J, Wijekoon HMS, Hosoya K, Okumura M. Pentosan polysulfate inhibits IL-1β-induced iNOS, c-Jun and HIF-1α upregulation in canine articular chondrocytes. PLoS One. 2017 May 4;12(5):e0177144. doi: 10.1371/journal.pone.0177144. PMID: 28472120; PMCID: PMC5417682.
Bwalya EC, Kim S, Fang J, Wijekoon HMS, Hosoya K, Okumura M. Effects of pentosan polysulfate and polysulfated glycosaminoglycan on chondrogenesis of canine bone marrow-derived mesenchymal stem cells in alginate and micromass culture. J Vet Med Sci. 2017 Jul 7;79(7):1182-1190. doi: 10.1292/jvms.17-0084. Epub 2017 May 27. PMID: 28552861; PMCID: PMC5559361.