Research

Current work: 

Surgery free injectable hydrogel for solid tumor immunotherapy

Herein, I am trying to develop an injectable hydrogel system made up of biocompatible and biodegradable polymers in order to deliver Chimeric antigen receptor (CAR)-T cells or CAR-directed nanovectors against specific solid tumor antigens. Solid tumor environemnt is complex and heterogenous therbey impeding the treatment efficacy by limiting the access of therapeutic to the tumor core. Alongside, the TME is extremely immunosuppressive which results in failure of immunotherapy and ultimately most of the patients show relapse. I am trying to overcome these problems by delivering cues through injectable biomaterials. This essentially overcomes the need for surgery and ensures patient compliance. Along with that, it improves the therapeutic efficacy of CAR-T cells as the gel is administered locally near the tumor site. Altogether, this work sims to develop an easy, cost-effective immunotherapeutic platform for CAR-T cell therapy in case of solid tumors. 

Previous Experience

M.Sc. Dissertation: In my Master's Dissertation, I have assessed the potential of Indian Mustard honey in inhibiting 5-Fluoro Uracil resistant Colon cancer stem cells through Inhibition of Lgr5, under the Supervision of Prof. Partha Roy, at Molecular Endocrinology Lab, BSBE,  Indian Institute of Technology Roorkee.

Internship: With the assistance of Shastri Research Student Fellowship (SRSF 2020) by Shastri Indo-Canadian Institute (SICI), I have pursued a research internship under the supervision of Prof. Marianna Foldvari of School of Pharmacy, University of Waterloo, Canada, along with Prof. Partha Roy, BSBE, IIT Roorkee. Here, I have evaluated the potential of functionalized Multi-Walled Carbon Nanotubes (CNTs) in microRNA delivery across Blood-Brain barrier in In vitro models.