Publications
Lab members are underlined; † and * denotes equal contribution and corresponding respectively.
Lab members are underlined; † and * denotes equal contribution and corresponding respectively.
Publications
S. A. Ali, Z. A. Ansari, R. Montalbo, H. Ayalew, Y.‐S. Hsiao, C.‐W. Chu, H.‐H. Yu, and H.‐L. Tu* A monolithic janus hydrogel pressure sensor for wearable motion and physiological monitoring. Advanced Science 2026, .
Noor Hidayat Abu Bakar and Hsiung‐Lin Tu* Integrating low‐voltage microfluidics with on‐chip electrospray ionization for miniaturized protein analysis. Small Methods 2026, .
Tsai-Fang Chou, Huan-Chi Chiu, Sofani T. Gebreyesus, Guan-Fu Chen, Yi-Ju Chen, Abigail R. Velasquez, Kuo-I Lin, Yu-Ju Chen* and Hsiung-Lin Tu* MiProChip: A scalable microfluidic platform for multiplexed single-cell proteomics via isobaric labeling. Analytical Chemistry 2026, 98(9),6874-6886.
Samuel Herianto and Hsiung-Lin Tu* Recent insights into bacterial ESCRT-III-mediated membrane remodeling. Critical Reviews in Biochemistry and Molecular Biology 2026, 61,1–19.
Meng-Jie Wu, Reynaldo Montalbo, Chun-Jen Su, Orion Shih and Hsiung-Lin Tu* One-step photochemical synthesis of gold-polymer nanohybrids with engineered morphologies and catalytic activity. Nanoscale 2026, 18 (8),4074–4084.
K.-H. Lyu, J.-W. Chen, D.-Y. Jin, Y.-J. Huang, H.-L. Tu, A. K Adak* and Chun-Cheng Lin* Boronate-mediated covalent and oriented immobilization of antibodies on the PDMS surface toward improved capture of circulating tumor cells. Lab on a Chip 2026, 26 (1),211-219.
S. Herianto, H.-M. Lee, C. Chen, J.-A. Ho, and H.-L. Tu* Functional reconstitution of bacterial ESCRT-III protein PspA identifies key regions in membrane binding and remodeling. Protein Science 2025, 34(10),e70309.
K. Devi, M. Ganesan, S.-M. Chen, Y. Li, H.-L. Tu, C.-M. Wang, Y.-F. Duann, G. Gopu Graphitic carbon nitride-embedded MXene tungsten carbide nanoflakes for sensitive detection of cytotoxic tinidazole in biological samples. Journal of the Taiwan Institute of Chemical Engineers 2025, 171,106072.
S. Ali, Y.-L. Chen, H.-S. Tseng, H. Ayalew, J.-W. She, B. Gautam, H.-L. Tu*, Y.-S. Hsiao*, and H.-H. Yu* Poly(3,4-ethylenedioxythiophene) Nanorod Arrays-Based Organic Electrochemical Transistor for SARS-CoV-2 Spike Protein Detection in Artificial Saliva. ACS Sensors 2025, 10(3),2007-2018.
J.-F. Xie, P.-C. Wei, Y. Li, C.-C. Chang, K.-C. Chang, C.-P. Lu, T. Hsu, D.-L. Tzou, H.-L. Tu*, and C.-M. Wang* Unique Organic–Inorganic Hybrid Copper(I) Phosphate with Ultralow Ractopamine Detection Limit and In Situ Sensing Ability. Inorganic Chemistry 2025, 64(9),4408-4414.
Gul Muneer, Sofani Gebreyesus, Ciao‐Syuan Chen, Tzu‐Tsung Lee, Fengchao Yu, Chih‐An Lin, M.‐S. Hsieh, A. I. Nesvizhskii, Chao‐Chi Ho, Sung‐Liang Yu, Hsiung‐Lin Tu*, and Yu‐Ju Chen* Mapping Nanoscale‐To‐Single‐Cell Phosphoproteomic Landscape by Chip‐DIA. Advanced Science 2025, 2025,12(1), 2402421.
Subburaj Srinithi, Naveen Karuppusamy, S.M. Chen*, S. Balaji Natarajan, Balakumar Vellaichamy*, Ying Li, Hsiung-Lin Tu*, Chih-Min Wang*, and Yeh-Fang Duann* Ultra-sensitive zinc cobaltate assembled on N-rich carbon nitride electrochemical sensor for the detection of paraquat in food samples. Journal of the Taiwan Institute of Chemical Engineers 2024, 165,105779.
Fei-Ting Hsu*, Ying-Tzu Chen, Yu-Cheng Chin, Li-Chan Chang, Shu-Chin Chiang, Li-Xing Yang, Hua-Shan Liu, Po-Fu Yueh, Hsiung-Lin Tu, Ruei-Yu He, Long-Bin Jeng, Woei-Cheang Shyu, Shang-Hsiu Hu, I-Tsang Chiang, Yu-Chang Liu, Yi-Chun Chiu, Guan-Chun Wu, Ching-Ching Yu, Wen-Pin Su*, and Chih-Chia Huang* Harnessing the Power of Sugar-Based Nanoparticles: A Drug-Free Approach to Enhance Immune Checkpoint Inhibition against Glioblastoma and Pancreatic Cancer. ACS Nano 2024, 18,28764-28781.
Reynaldo C. Montalbo, Meng-Jie Wu and Hsiung-Lin Tu* One-step flow synthesis of size-controlled polymer nanogels in a fluorocarbon microfluidic chip. RSC Advances 2024, 14(16),11258-11265.
Chieh-Teng Cheng, Jye-Chian Hsiao, Alexander Hoffmann and Hsiung-Lin Tu* TNFR1 mediates heterogeneity in single-cell NF-κB activation. iScience 2024, 27 (4),109486.
Mu-Chien Yin, Pi-Chen Wei, Ying Li, Todd Hsu, Jia-Yi Jian, Kai-Chi Chang, Ching-Ping Lu, Hsiung-Lin Tu*, Chih-Min Wang* Structural Variants and Ultralow Detection Ability for Tryptamine in Two Polymorphs of a Zincophosphite Framework. Inorganic Chemistry 2023, 62(44),18150-18156.
Narani Rakesh†, Hsiung‐Lin Tu†, Po‐Chun Chang, Sofani T. Gebreyesus, Che‐Jen Lin* Innovative real‐time flow sensor using detergent‐free complex emulsions with dual‐emissive semi‐perfluoroalkyl substituted <i>Α</i>‐cyanostilbene. Advanced Science 2023, 10(31),2304108.
Ying-Chi Chen, Ying Li, Ching-Cher S. Yan, Chao-Ping Hsu, Pei-Lin Cheng* and Hsiung-Lin Tu* DNA tension assays reveal that force-dependent integrin activation regulates neurite outgrowth in primary cortical neurons. Biomaterials Advances 2023, 150,213431.
Ying Li, Chiao-Chun Chang, Chu Wang, Wen-Ti Wu, Chih-Min Wang* and Hsiung-Lin Tu* Microfluidic biosensor decorated with an indium phosphate nanointerface for attomolar dopamine detection. ACS Sensors 2023, 8(6),2263-2270.
Reynaldo Carlos K. Montalbo and Hsiung-Lin Tu* Micropatterning of functional lipid bilayer assays for quantitative bioanalysis (Invited Perspective). Biomicrofluidics 2023, 17(3),031302.
Sofani Gebreyesus, Gul Muneer, Chih-Cheng Huang, Asad Siyal, Mihir Anand, Yu-Ju Chen and Hsiung-Lin Tu* Recent advances in microfluidics for single-cell functional proteomics. Lab on a Chip 2023, 23,1726-1751.
Samuel Herianto, Po-Jen Chien, Ja-an Annie Ho and Hsiung-Lin Tu* Liposome-based artificial cells: From gene expression to reconstitution of cellular functions and phenotypes. Biomaterials Advances 2022, 142,213156.
Chen Chen, Chien-Hsin Chu, Ying Chu, Ting-Ya Chang, Sheng-Wen Chen, Shu-Yang Liang, Yun-Chi Tsai, Bi-Chang Chen, Hsiung-Lin Tu and Pei-Lin Cheng* Neuronal paxillin and Drebrin mediate BDNF-induced force transduction and growth cone turning in a soft tissue-like environment. Cell Reports 2022, 40 (7),111188.
Po-Jen Chien, Yi-Lun Shih, Chieh-Teng Cheng and Hsiung-Lin Tu* Chip assisted formation of phase-separated liposomes for reconstituting spatial protein–lipid interactions. Lab on a Chip 2022, 22,2540-2548.
Shih-Han Kao, Shu-Yang Liang, Pei-Lin Cheng and Hsiung-Lin Tu* Surface viscosity-dependent neurite initiation in cortical neurons. Advanced Biology 2022, 6 (6),2101325.
Sofani Gebreyesus, Asad Siyal, Reta Kitata, Eric Sheng-Wen Chen, Bayarmaa Enkhbayar, Takashi Angata, Kuo-I Lin, Yu-Ju Chen* and Hsiung-Lin Tu* Streamlined single-cell proteomics by an integrated microfluidic chip and data-independent acquisition mass spectrometry. Nature Communications 2022, 13,37.
Asad Siyal, Eric Sheng-Wen Chen, Hsin-Ju Chan, Reta Birhanu Kitata, Jhih-Ci Yang, Hsiung-Lin Tu and Yu-Ju Chen* Sample Size-Comparable Spectral Library Enhances Data-Independent Acquisition-Based Proteome Coverage of Low-Input Cells. Analytical Chemistry 2021, 93 (51),17003-17011.
Chu Wang , Jia-Rong Li, Ying Li, Hsiung-Lin Tu, Der-Lii M Tzou and Chih-Min Wang* Stable Crystalline Organic-Inorganic Hybrid Indium Phosphate with Dye Removal and Ractopamine Detection Applications. Inorganic Chemistry 2021, 60 (15),11655-11660.
Yu-Ting Ti, Hsiao-Chi Cheng, Ying Li and Hsiung-Lin Tu* Multiplexed patterning of hybrid lipid membrane and protein arrays for cell signaling study. Lab on a Chip 2021, 21,2711-2720.
Da-Wei Lin, Yang Liu, Yue-Qi Lee, Po-Jiun Yang, Chia-Tse Ho, Jui-Chung Hong, Jye-Chian Hsiao, Der-Chien Liao, An-Jou Liang, Tzu-Chiao Hung, Yu-Chuan Chen, Hsiung-Lin Tu, Chao-Ping Hsu and Hsiao-Chun Huang* Construction of intracellular asymmetry and asymmetric division in Escherichia coli. Nature Communications 2021, 12,888.
Minjun Son, Andrew Wang, Hsiung-Lin Tu, Marie Metzig, Parthiv Patel, Kabir Husain, Jing Lin, Arvind Murugan, Alexander Hoffmann and Savaş Tay* NF-κB responds to absolute differences in cytokine concentrations. Science Signaling 2021, 14 (666),eaaz4382.
Ying Li, Ji-Fang Xie, Chiao-Chun Chang, Chih-Min Wang * and Hsiung-Lin Tu* Highly Sensitive Detection of Mercury Ions Using Zincophosphite Framework Nanoparticle-Polyaniline Composites. ACS Applied Nano Materials 2020, 3 (10),9724-9730.
Jui Hsieh, Ju-Ying Chen, Han-Ying Li, Hsin-Kuan Liu, Hsiung-Lin Tu and Chih-Min Wang* A thio-functionalized zinc phosphite with a large-channel framework and enhanced removal ability of mercury ion from aqueous solutions. Dalton Transactions 2020, 49 (32),11085-11089.
Udesh Dhawan, Wei‐Li Wang, Bhaskarchand Gautam, Jayakrishnan Janardhanan, Po‐Chiang Hsiao, Hsiung‐Lin Tu and Hsiao‐Hua Yu* Mechanotactic Activation of TGF‐β by PEDOT Artificial Microenvironments Triggers Epithelial to Mesenchymal Transition. Advanced Biosystems 2020, 4 (2),1900165.
Jing Lin, Christian Jordi, Minjun Son, Hoang Van Phan, Nir Drayman, Mustafa Abasiyanik, Luke Vistain, Hsiung-Lin Tu and Savaş Tay* Ultra-sensitive digital quantification of proteins and mRNA in single cells. Nature Communications 2019, 10(1),3544.
Ce Zhang, Hsiung-Lin Tu, Gengjie Jia, Tanzila Mukhtar, Verdon Taylor, Andrey Rzhetsky and Savaş Tay* Ultra-multiplexed analysis of single-cell dynamics reveals logic rules in differentiation. Science Advances 2019, 5(4),eaav7959.
S. Christensen, H.-L. Tu, J. Jun, S. Alvarez, M. Triplet, J. Iwig, K. Yadav, D. Bar-Sagi, J. Roose and J. Groves One-way Membrane Trafficking of SOS in Receptor-Triggered Ras Activation. Nature Structural & Molecular Biology 2016, 23,838-846.
W. Y.-C. Huang, Q. Yan, W.-C. Lin, J. Chung, S. Hansen, S. Christensen, H.-L. Tu, J. Kuriyan and J. Groves Phosphotyrosine-mediated LAT Assembly on Membranes Drives Kinetic Bifurcation in Recruitment Dynamics of The Ras Activator SOS. Proceedings of the National Academy of Sciences USA 2016, 113,8218-8223.
S. Christensen, M. Triplet, C. Rhodes, J. Iwig, H.-L. Tu, D. Stamou and J. Groves Monitoring The Waiting Time Sequence of Single Ras GTPase Activation Events Using Liposome Functionalized Zero Mode Waveguides. Nano Letters 2016, 16,2890-2895.
L. Iversen, H.-L. Tu, W.-C. Lin, S. Christensen, S. Abel, J. Iwig, H.-J. Wu, J. Gureasko, C. Rhodes, R. Petit, S. Hansen, P. Thill, C.-H. Yu, D. Stamou, A. Chakraborty, J. Kuriyan and J. T. Groves Ras Activation by SOS: Allosteric Regulation by Altered Fluctuation Dynamics. Science 2014, 345,50-54.
W.-C. Lin, L. Iversen, H.-L. Tu, C. Rhodes, S. Christensen, J. Iwig, S. Hansen, W. Huang and J. Groves H-Ras Forms Dimers on Membrane Surfaces via A Protein-Protein Interface. Proceedings of the National Academy of Sciences USA 2014, 111,2996-3001.
T. Lohmüller, L. Iversen, M. Schmidt, C. Rhodes, H.-L. Tu, W.-C. Lin and J. T. Groves Single Molecule Tracking on Supported Membranes with Arrays of Optical Nanoantennas. Nano Letters 2012, 12,1717-1721.
H.-L. Tu, Y.-S. Lin, H.-Y. Lin, Y. Hung, L.-W. Lo, Y.-F. Chen and C.-Y. Mou In-vitro Studies of Functionalized Mesoporous Silica Nanoparticles for Photodynamic Therapy. Advanced materials 2009, 21,172-177.
H.-L. Tu, F.-Y. Tsai and C.-Y. Mou One Step Synthesis of Ordered Mesostructural Organic/silica Nanocomposite with Tunable Fluorescence Surfactants. Journal of materials chemistry 2008, 18,1771-1778.
F.-Y. Tsai, H.-L. Tu and C.-Y. Mou. Nonionic Fluorescent Oligomeric Surfactant for Ordered Mesoporous Silica Structure. Journal of materials chemistry 2006, 16,348-350.