Hl Sharma Pharmacology Latest Edition Pdf Download

The twelfth edition of this long-established textbook of clinical pharmacology (first published in 1960) continues its fine tradition of balancing science and practice for improved evidence-based drug therapy and good prescribing in therapeutic settings increasingly complicated by intercurrent disease and polypharmacy.

Dr. Sharma has more than 20 years of extensive experience in research and teaching of cardiovascular physiology and pharmacology.

Dr. Sharma has been instrumental in developing the infrastructure for research at the School of Pharmacy duly supported by PCOM. In a newly-developed Pharmacy Research Laboratory at the Georgia campus, Dr. Sharma is developing an in vitro paradigm (using stem cell derived cardiomyocyte and primary human cardiomyocyte culture) to assess in vivo clinical cardiovascular pathophysiology. Dr. Sharma envisions advancing the Department of Pharmaceutical Sciences as a platform for the growth and development of students and faculty at the PCOM School of Pharmacy - Georgia Campus.

As a member of Executive Leadership Team of the PCOM School of Pharmacy, Dr. Sharma is integral part of accreditation process (governed by Accreditation Council of Pharmacy Education). Dr. Sharma is leading the department of pharmaceutical sciences in providing education to professional PharmD students at the School of Pharmacy.

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In addition to pharmacy calculations, other factors in pharmacology must also be a consideration. For instance, bioavailability is the amount of drug from the administered dose that reaches the systemic circulation and should be taken into account. Different routes of administrations can impact drug bioavailability.

A good book is one which interests and guides a student even in the absence of a teacher. What does a student look for in a text book of pharmacology? Well, many things, but essentially the following:

The textbook "Principles of Pharmacology" by H. L. Sharma and K. K. Sharma fulfills these and more. This text book on pharmacology is primarily targeted toward undergraduate medical students. To begin with, the topics included are contemporary and well classified. Special topics such as pediatrics and geriatric pharmacology and pharmacology of radiocontrast media and drug schedules have been included. The strength of this book lies in the detailed yet simple manner in which the topics in General Pharmacology have been dealt with. This will help the students understand the basic principles very well.

There is scope for modification in future editions. For example, the mathematical derivations and detailing of certain pharmacokinetic parameters could have been avoided. Also topics such as pharmacovigilance and adverse drug reaction monitoring, phramcoeconomics, prescription writing, drug compliance, drug discovery, and development and applied aspects of pharmacology could well be added or elaborated in future editions. The formulations, dose, and commonly available preparations could also be mentioned separately after each drug / drug group. Students usually find it difficult to remember these and need it as a handy reference for quick reading. Modern books in pharmacology demand a fine balance between the elucidation of basic concepts and applied clinical aspects. The latter needs more attention. A short bibliography at the end of each chapter could provide additional reading resources for the students who wish to study the topic in detail, for example, postgraduates or those who wish to prepare for the pre-PG entrance exams. However, a well written book, that will serve as a useful learning resource, not only to the teachers in pharmacology and undergraduate medical students, but also to paramedical students. The authors mention in the preface, "We ourselves carry a heart of a dissatisfied student which we kept on our desk while writing the chapters. If our hearts beat normally after the end of the chapter, we considered our job done successfully. It there were arrhythmias, we explored the reasons, rewrote the whole chapter". The authors have been successful in their endeavor and the book does preserve the sinus rhythm of the reader!

Subsequent to the first 2-adrenergic receptor (2-AR) gene cloning of 2-C10 from human platelet, cloning of the first rodent 2-AR cDNA, cA2-47, was reported. Based on the structural and limited pharmacological comparison, it was concluded that the rodent receptor is a molecular and pharmacological analog of the human receptor, which is pharmacologically classified as the 2A-AR. A later study slightly revised the structure of the human receptor. Thus, the precise structural comparison of the rat receptor to the human platelet receptor is no longer valid. Another rat 2-AR gene, RG20, was then cloned and was also found to be a structural analog of the human 2-C10. It, however, varied slightly from the 2A subtype pharmacology, but matched the newly defined 2D subtype pharmacology. It was, therefore, concluded that RG20 encodes the 2D subtype. The structural and pharmacological relationship of RG20 with cA2-47 is not known, although it has been tacitly assumed that both are the identical 2D receptor subtypes. The present study addresses this and other issues relating to the precise structural, genetic and pharmacological relationship of cA2-47 with the human platelet 2-C10 receptor, and also the localization of cA2-47 transcipt in certain rat tissues. The results show that the cA2-47 receptor shows a high degree of sequence identity to the 2-C10 receptor, yet important differences exist between them. The sequence identity of cA2-47 receptor to the RG20 receptor is almost, but not quite complete. The cA2-47 gene is not present in the human and the human gene is not present in the rat; that cA2-47 receptor subtype is pharmacologically similar to the RG20 receptor subtype, both being of the 2D subtype. The cA2-47 receptor transcript in addition to being found in the rat brain is present in the rat adrenal gland, testes, adrenocortical carcinoma and the bovine retina. e24fc04721