The city has played an important part in the development of northern Metro Manila over its lengthy history. Before the Philippine Independence in 1898, the city was separated economically into a Spanish friar hacienda, a minor political town, and a Spanish garrison. Bulacan province used to include Valenzuela City. Its vast land area was subdivided into Polo, Novaliches, Obando, and other provinces in the 19th century, all of which were amalgamated into the province of Morong. The city became part of Bulacan later in the American period, and the colonial government commissioned the construction of Marcelo H. del Pilar Expressway is a highway that runs through the city of El Paso, Texas During Marcos' presidency, the road was renamed North Luzon Expressway.
Valenzuela was divided into two towns after the Philippines were liberated from Japanese domination in 1946.
President Carlos P. Garcia approved a measure in 1960 that established Valenzuela as a separate municipality from Bulacan. The bill was repealed in 1963, reuniting the northern Polo with Bulacan and establishing the southern Valenzuela town as a separate municipality. During Marcos' presidency, the Metro Manila Commission and the National Capital Region were established, resulting in the 1975 union of Polo and Valenzuela into the municipality of Valenzuela. Valenzuela was incorporated as a city on February 14, 1998.