Histology Guide ~UPD~

Histology Guide teaches the visual art of recognizing the structure of cells and tissues and understanding how this is determined by their function. Rather than reproducing the information found in a histology textbook, a user is shown how to apply this knowledge to interpret cells and tissues as viewed through a microscope.

Because of the high cost of purchasing (and maintaining) microscopes and preparing (or purchasing) slide collections, histology is often taught today without laboratories. A histology atlas is frequently used as a replacement. This is unfortunate because no matter how good the few images in a textbook or histology atlas are, they cannot replace the experience of viewing a specimen through a microscope.

Histology Guide

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Histology is the science of the microscopic structure of cells, tissues and organs. It also helps us understand the relationship between structure and function. By examining a thin slice of bone tissue under a microscope, colorized with special staining techniques, you see that these seemingly simple bones are actually a complex microworld containing an array of structures with various different functions. In this article, we will introduce you to the microscopic world of histology.

Each organ of the digestive system has properties that make it specialized for its role in the digestion, absorption and excretion of food. For example, the simple columnar epithelium of the stomach fundus contains special parietal cells which secrete HCl to break down meat proteins. Pancreatic serous acini secrete digestive enzymes which break down fat, carbohydrates and proteins. Everything absorbed through the alimentary tract passes through the special discontinued capillaries of the liver before going anywhere else. This is because the liver, among many other things, is the major detoxifying machine of the body. Did you know that chronic alcoholics have a lot more smooth endoplasmic reticulum concentrations in their hepatocytes? This is why doctors must take extra caution when prescribing medication to these people. Learn more about the histology of the upper and lower digestive tract.

The tools for studying histology are becoming more diverse everyday. The most used tool today for examining cells, tissues and organs is optic (light) microscopy. For an even more detailed view, an electron microscopy can be used. Other methods include histochemistry, immunocytochemistry, hybridization techniques, tissue culture and many others.

The 2007 Multiple Primary and Histology Coding Rules present the first site-specific multiple primary and histology rules developed to promote consistent and standardized coding by cancer registrars. These rules should be used for cases diagnosed from 2007 to 2017. See Registrar Training to view documents and transcripts from the MP/H Rules training sessions.

The 2007 Multiple Primary and Histology Coding Rules contain site-specific rules for lung, breast, colon, melanoma of the skin, head and neck, kidney, renal pelvis/ureter/bladder, benign brain, and malignant brain. A separate set of rules addresses the specific and general rules for all other sites. The multiple primary rules guide and standardize the process of determining the number of primaries. The histology rules contain detailed histology coding instructions. For example, grouping histologic terms, differentiating between general (NOS) terms and specific histologic types and subtypes, and identifying mixed and combination codes are covered. The MP/H Task Force also developed three new data items that complement these rules.

There are an overwhelming number of stains for histology. In this section, we provide details on some of the most commonly used stains, how and when to use them, and tips for getting your staining just right.

Didn't find what you were looking for? Or perhaps you have some tips and tricks on histology basics that we haven't covered here? Get in touch and let us know so we can continue to improve the information we share!

From patient to pathologist, preparing tissue specimens for histological examination requires care, skill and sound procedures. This straightforward guide to good histology practice provides practical advice on best-practice techniques and simple ways to avoid common errors. Each aspect of the histology process is covered:

Each chapter begins with introductory text that is essential information for understanding and learning the histology slides. This is followed by an Observe and Note section which serves as a check list of the essential features of the tissue specimens for that chapter. Illustrations are included where needed to facilitate understanding the content and context of the microscope sections. All specimens are fully labeled. The atlas serves as a reference as well as a guide to promote and enhance virtual microscope experience in Histology Guide. Although the Atlas was designed for use with Histology Guide, it can be used independent of the website.

Anatomy refers to the internal and external structures of the body and their physical relationships. Physiology refers to the study of the functions of those structures. Histology is the study of tissues and their structure. The structure of tissues is directly related to its function therefore histology, physiology, and anatomy are all interrelated. The understanding of one leads to the greater understanding of the others.

The Banff Classification of Allograft Pathology is an international consensus classification for the reporting of biopsies from solid organ transplants. Since its initial conception in 1991 for renal transplants, it has undergone review every 2 years, with attendant updated publications. The rapid expansion of knowledge in the field has led to numerous revisions of the classification. The resultant dispersal of relevant content makes it difficult for novices and experienced pathologists to faithfully apply the classification in routine diagnostic work and in clinical trials. This review shall provide a complete and simple illustrated reference guide of the Banff Classification of Kidney Allograft Pathology based on all publications including the 2017 update. It is intended as a concise desktop reference for pathologists and clinicians, providing definitions, Banff Lesion Scores and Banff Diagnostic Categories. An online website reference guide hosted by the Banff Foundation for Allograft Pathology (www.banfffoundation.org) is being developed, which will be updated with future refinement of the Banff Classification from 2019 onward.

The Banff classification is the gold standard in kidney transplantation for both pathologists and clinicians. As this classification is evolving quickly, the authors provide a complete and simple illustrated reference guide to help everyone taking advantage of this growing piece of knowledge.

For more on "Gut-Associated Lymphoid Tissues" (GALT, or MALT for Mucosa-Associated Lymphoid Tissues), consult your histology text. For a recent research perspective, see "Immunity, Inflammation, and Allergy in the Gut," Science 307:1920 (2005).

THIS little book provides an excellent guide to practical work for first-year students in histology and vertebrate embryology. Dr. Eales is an experienced and successful teacher and knows well the pitfalls that lie in the way of the beginner. The simplest methods and a small number of fixatives and stains have been chosen out of the bewildering variety that are at the disposal of the more advanced worker. Directions are given for preparing simple histological injections and for the elementary technique of mammalian embryology, both of which are usually omitted from the first-year course. It may perhaps be suggested that the simplification of methods might perhaps have been carried a little further with advantage; that rough hand-cut sections might have been substituted oftener for the more elegant products of the microtome. Many beginners, and even some more advanced students, have great difficulty in relating the two-dimensional picture presented by a microtome section to the three-dimensional structure of a tissue or an embryo. Sections cut, however inexpertly, by the student himself, do help him over this difficulty.

Treatment (TRE): Protocol designed to evaluate one or more interventions for treating a disease, syndrome, or condition. Note: This equates to therapeutic trials in previous versions of the guidelines.

The Histology Guide gives the student a virtual experience of using a microscope rather than trawling through text and figures or a set of powerpoint slides. The aim of this site is to give students the opportunity to study high quality digital images in histology. The site is interactive and is divided into topics that the students must work through. While students are watching histological slides, they can turn labels on or off to help them identify features. In some cases, students can see a section through a "virtual microscope", and they can scan around a large picture using the mouse and try to identify features. Students can also zoom in on a slide, having identified an area of interest. A Self Test Option is provided with each topic. Content: What is Histology; The Cell; Basic Tissue Types; Blood; Circulatory System; Skin; Respiratory System; Oral Tissues; Digestive System; Cartilage, Bone & Ossification; Lymphoid Tissue; Female Reproductive System; Male Reproductive System; Urinary System; Glandular Tissue. Other options: Search the Histology Guide. Most of the topics start with an introduction. e24fc04721