Google Scholar: https://scholar.google.com/citations?user=iK_UKQsAAAAJ&hl=en

My NCBI Bibliography: https://www.ncbi.nlm.nih.gov/myncbi/ryan.hibbs.1/bibliography/public/ 

*Equal contributions; #Co-corresponding authors 

Peer-reviewed Publications

*Equal contributions; #Co-corresponding authors

1. Mazzaferro S*, Kang G*, Natarajan K, Hibbs RE#, Sine SM#. "Structural bases for stoichiometry-selective calcium potentiation of a neuronal nicotinic receptor." British Journal of Pharmacology 2024 March 7. PMID: 38454578.

2. Burke SM, Avstrikova M, Noviello CM, Mukhtasimova N, Changeux JP, Thakur GA, Sine SM#, Cecchini M#, Hibbs RE#. "Structural mechanisms of α7 nicotinic receptor allosteric modulation and activation." Cell 2024 Feb 20. PMID: 38382524.

3. Legesse DH, Fan C, Teng J, Zhuang Y, Howard RJ, Noviello CM, Lindahl E#, Hibbs RE#. "Structural insights into opposing actions of neurosteroids on GABAA receptors." Nature Communications 2023 Aug 22. PMID: 37607940.

4. Goswami U, Rahman MM, Teng J, Hibbs RE. "Structural interplay of anesthetics and paralytics on muscle nicotinic receptors." Nature Communications 2023 Jun 1;14(1):3169. PMID: 37264005.

5. Allard CAH*, Kang G*, Kim JJ*, Valencia-Montoya WA, Hibbs RE# and Bellono NW#. “Structural basis of sensory receptor evolution in octopus. Nature 12 April 2023. PMID: 37045920.

6. Kang G*, Allard CAH*, Valencia-Montoya WA*, van Giesen L, Kim JJ, Bai X, Bellono NW# and Hibbs RE#. “Sensory specializations drive octopus and squid behavior.” Nature 12 April 2023. PMID: 37045917.

*Two articles featured on the cover, with a film: https://www.nature.com/articles/d41586-023-01013-0 and news:

      https://www.nature.com/articles/d41586-023-01010-3.

7. Zhuang Y, Noviello CM, Hibbs RE, Howard RJ, Lindahl E. “Differential interactions of resting, activated, and desensitized states of the α7 nicotinic acetylcholine receptor with lipidic modulators.” PNAS 2022 Oct 25;119(43):e2208081119. PMID: 36251999

8. Zhu, S, Sridhar, A, Teng, J, Howard, RJ, Lindahl, E Hibbs, RE “Structural and dynamic mechanisms of GABAA receptor modulators with opposing activities.” Nature Communications 2022 Aug 6;13(1):4582. PMID: 35933426

9. Noviello, C.M., Kreye, J., Teng, J., Pruss, H.# and Hibbs, R.E.# “Structural mechanisms of GABAA receptor autoimmune encephalitis.” Cell 2022 Jul 7;185(14):2469-2477.e13. PMID: 35803245

10. Rahman, M.M., Basta, T., Teng, J., Lee, M., Worrell, B.T., Stowell, M.H.B.# and Hibbs, R.E.# “Structural mechanism of muscle nicotinic receptor desensitization and block by curare.” Nature Structural & Molecular Biology 2022 Apr;29(4):386-394. PMID: 35301478. Selected for cover.

11. Noviello, C.M., Gharpure, A., Mukhtasimova, N., Cabuco, R., Baxter, L., Borek, D., Sine, S.M. and Hibbs, R.E. “Structure and gating mechanism of the α7 nicotinic acetylcholine receptor.” Cell 2021 184(8):2121-2134. PMID: 33735609.

12. Kim, J.J., Gharpure, A., Teng, J., Zhuang, Y., Howard, R.J., Zhu, S., Noviello, C.M., Walsh, R.M. Jr., Lindahl, E., Hibbs, R.E. “Shared structural mechanisms of general anesthetics and benzodiazepines.” Nature 2020 585(7824):303-308. PMID: 32879488.

13. Rahman, M.M., Teng, J., Worrell, B.T., Noviello, C.M., Lee, M., Karlin, A., Stowell, M.H.B.# and Hibbs, R.E.# “Structure of the native muscle-type nicotinic receptor and inhibition by snake venom toxins.” Neuron 2020 106(6):952-962. PMID: 32275860.

*Featured in Neuron Spotlight: “Golden Anniversary of the Nicotinic Receptor” by Jean-Pierre Changeux. 8 July 2020. 

14. Brams M., Govaerts C., Kambara K., Price K.L., Spurny R., Gharpure A., Pardon E., Evans G.L., Bertrand D., Lummis S.C., Hibbs R.E., Steyaert J., Ulens C. “Modulation of the Erwinia ligand-gated ion channel (ELIC) and the 5-HT3 receptor via a common vestibule site.” Elife. 2020 Jan 28;9. pii: e51511. doi: 10.7554/eLife.51511. PMID: 31990273

15. Mann N., Kause F., Henze E.K., Gharpure A., Shril S., Connaughton D.M., Nakayama M., Klämbt V., Majmundar A.J., Wu C.W., Kolvenbach C.M., Dai R., Chen J., van der Ven A.T., Ityel H., Tooley M.J., Kari J.A., Bownass L, El Desoky S., De Franco E., Shalaby M., Tasic V., Bauer S.B., Lee R.S., Beckel J.M., Yu W., Mane S.M., Lifton R.P., Reutter H., Ellard S., Hibbs R.E., Kawate T., Hildebrandt F. “CAKUT and Autonomic Dysfunction Caused by Acetylcholine Receptor Mutations.” Am J Hum Genet 2019: 105(6):1286-1293. PMID: 31708116.

16. Gharpure, A., Teng, J., Zhuang, Y., Noviello, C.M., Walsh, R.M. Jr., Cabuco, R., Howard, R.J., Zaveri, N.T., Lindahl, E. and Hibbs, R.E. “Agonist selectivity and ion permeation in the α3β4 ganglionic nicotinic receptor.” Neuron 2019: 104(3)501-511. PMID: 31488329

*Featured in Neuron preview: “Nicotine Bound to Its Receptors: New Structures for a Vexing Pathopharmacological Problem” by Henry Lester and Dennis Dougherty. 6 November 2019.

17. Zoltowski B.D., Chelliah Y., Wickramaratne A., Jarocha L., Karki N., Xu W., Mouritsen H., Hore P.J., Hibbs R.E., Green C.B., Takahashi J.S. “Chemical and structural analysis of a photoactive vertebrate cryptochrome from pigeon.” PNAS. Online publication date Sept 4, 2019. PMID: 31484780.

18. Stokes, C., Garai, S., Kulkarni, A.R., Cantwell, L.N., Noviello, C.M., Hibbs, R.E., Horenstein, N.A., Abboud, K.A., Thakur, G.A., Papke, R.L. “Heteromeric Neuronal Nicotinic Acetylcholine 15. Receptors with Mutant β Subunits Acquire Sensitivity to α7-Selective Positive Allosteric Modulators.” J Pharmacol Exp Ther 2019: 370:252-268. PMID: 31175218.

19. Zhu, S., Noviello, C.M., Teng, J., Walsh, R.M. Jr., Kim, J.J. and Hibbs, R.E. “Structure of a human synaptic GABAA receptor.” Nature 2018: 559(7712):67-72. PMID: 29950725. Selected for cover.

*Featured in Nature editorial: “Brain-protein structure could point way to safer prescription drugs.” 27 June 2018.

*Featured in Nature News & Views: “Key receptor involved in neuronal signalling visualized.” Author: Erwin Sigel. 2 July 2018.

20. Walsh, R.M. Jr.#, Roh S.H.#, Gharpure, A., Morales-Perez, C.L., Teng, J. and Hibbs, R.E. “Structural principles of distinct assemblies of the human α4β2 nicotinic receptor.” Nature 2018: 557(7704):261-265. PMID: 29720657. #Equal contribution.

21. Morales-Perez, C.L., Noviello, C.M. and Hibbs, R.E. “X-ray structure of the human α4β2 nicotinic acetylcholine receptor.” Nature 2016: 538(7625):411-415. PMID: 27698419.

22. Morales-Perez, C.L., Noviello, C.M. and Hibbs, R.E. “Manipulation of subunit stoichiometry in heteromeric membrane proteins.” Structure 2016: 24(5):797-805. PMID: 27041595.

*Featured in Structure Preview: “Production of Heteromeric Transmembrane Receptors with Defined Subunit Stoichiometry.” Authors: Malinkauskas, T. and Furukawa, H. PMID: 27145073.

Postdoc and PhD

23. Althoff, T.*, Hibbs, R.E.*, Banerjee, S. and Gouaux E. “X-ray structures of GluCl in apo states illuminate gating mechanism of Cys-loop receptors.” Nature 2014: 512(7514)333-7. PMID: 25143115. *Equal contribution.

24. Hattori, M.*, Hibbs, R.E.* and Gouaux, E. "A fluorescence-detection size-exclusion chromatography-based thermostability assay for membrane protein precrystallization screening." Structure 2012: 20(8):1293-9. PMID: 22884106. *Equal contribution.

25. Hibbs, R.E. and Gouaux, E. “Principles of activation and permeation in an anion-selective Cys-loop receptor.” Nature 2011: 474(7349):54-60. PMID: 21572436

26. Hibbs, R.E.*, Sulzenbacher, G.*, Shi, J., Talley, T.T., Conrod, S., Kem, W.R., Taylor, P., Marchot, P., Bourne, Y. “Structural determinants for interaction of partial agonists with acetylcholine binding protein and neuronal alpha7 nicotinic acetylcholine receptor.” EMBO Journal 2009: 28(19):3040-3051. *Equal contribution. PMID: 19696737

27. Talley, T.T., Harel, M., Hibbs, R.E., Radić Z., Tomizawa, M., Casida, J.E., Taylor, P. “Atomic interactions of neonicotinoid agonists with AChBP: Molecular recognition of the distinctive electronegative pharmacophore.” PNAS 2008: 105(21)7606-7611. PMID: 18477694

28. Taylor, P., Talley, T.T., Radić, Z., Hansen, S.B., Hibbs, R.E., Shi, J. “Structure-guided drug design: conferring selectivity among neuronal nicotinic receptor and acetylcholine-binding protein subtypes.” Biochemical Pharmacology 2007: 74(8):1164-1171. PMID: 17826748

29. Hibbs, R.E., Radić, Z., Taylor, P., Johnson, D.A. “Influence of agonists and antagonists on the segmental motion of residues near the agonist binding pocket of the acetylcholine-binding protein.” Journal of Biological Chemistry 2006: 281(51)39708-39718. PMID: 17068341

30. Hibbs, R.E., Johnson, D.A., Shi, J., Hansen, S.B., Taylor, P. “Structural dynamics of the a-neurotoxin-acetylcholine binding protein complex: hydrodynamic and fluorescence anisotropy decay analyses.” Biochemistry 2005 (44)16602-16611. PMID: 16342951

31. Hibbs, R.E., Talley, T.T. and Taylor, P. “Acrylodan conjugated cysteine side chains reveal conformational state and ligand site locations of the acetylcholine binding protein.” Journal of Biological Chemistry 2004: 279(27):28483-28491. PMID: 15117947

32. Taylor P., Hansen S.B., Talley T.T., Hibbs R.E., Radić Z. “Contemporary paradigms for cholinergic ligand design guided by biological structure.” Bioorganic and Medicinal Chemistry Letters 2004: (14)1875-1877. PMID: 15050619

Reviews/Editorials

1. Kim, J.J. and Hibbs, R.E. “Direct structural insights into GABAA receptor pharmacology.” TiBS, online March 2021. PMID: 33674151

2. Gharpure, A., Noviello, C.M., Hibbs, R.E. “Progress in Nicotinic Receptor Structural Biology.” Neuropharmacology 2020: 171:108086. PMID: 32272141

3. Kim, J.J. and Hibbs, R.E. “Bridges between antimalarials and synaptic transmission.” Neuron 2019: 101(4)546-547. PMID: 30790532

Book Chapters

1. Rahman, M.M., Worrell, B.T., Stowell M.H.B., and Hibbs, R.E. “Purification of a native nicotinic receptor.” Methods in Enzymology. Volume 654: Ion Channels: Channel Chemical Biology, Engineering, and Physiological Function. Eds: Daniel L. Minor Jr. and Henry M. Colecraft. 2021 653:189-206.

2. Hibbs, R.E., Zambon, A. “Nicotine and agents acting at the neuromuscular junction and autonomic ganglia.” Goodman and Gilman’s The Pharmacological Basis of Therapeutics. 13th Edition. Eds. Laurence Brunton, Randa Hilal-Dandan and Bjorn Knollman. McGraw-Hill Publishing, 2018.

3. Hibbs, R.E., Zambon, A. “Agents acting at the neuromuscular junction and autonomic ganglia.” Goodman and Gilman’s The Pharmacological Basis of Therapeutics. 12th Edition. Eds. Laurence Brunton, Bruce Chabner and Bjorn Knollman. McGraw-Hill Publishing, 2011.