Interdisciplinary Critical Review of Leech Therapy; Evolution, Indications, Salivary Glan…. 16 evaluated for both treatment capability and their particular secreted molecules.There is huge potential for the invent of novel substances and these could be future therapeutics.After the study of SGS it can be stated with élan that used judiciously, leeches can get blood flowing in regions that even a skilled surgeon cannot. Compared to other techniques of complementary and natural therapy, Leech therapy can be learned relatively quickly and can reduce the complications arising from the excessive use of synthetic drugs.This article is a sincere attempt to highlight the relatively important areas of leech therapy with more clinical areas to be covered under the research domain on this wonder parasite. Conflict of interest- The Author doesn‘t have any conflict of interest. REFERENCES [1]. Hirudotherapy / Leech therapy: Applications and Indications in Surgery;Swaid Abdullah m Latief M. Dar ,AdilRashid,AnitaTewari ,Jan 2012,cited on www.scopemed.org on dated 4/3/201 [2]. AsutkarSheetal G; A Conceptual overview on Inflammatory markers in patients of Vranashopha(Cellulitis) and its management with Leech Therapy - International Journal of Innovative Pharmaceutical Sciences and Research-IJIPSR;Vol-4,Issue-1,pg no :15-28 ,l2016 ISSN no2347-2154 [3]. 1 I.S. Whitaker, J. Rao, D. Izadi, P.E. Butler-Historical article: Hirudomedicinalis: ancient origins of, and trends in the use of medicinal leeches throughout history;Br J Oral MaxillofacSurg, 42 (2004), pp. 133- 137 [4]. Sushruta; SushrutaSamhita; with the Nibandhasangraha commentary of Sri Dalhanacharya; Reprint edition, Edited by JadavajiTrikamjiAcharya, Varanasi; Chaukhambhaorientalia publishers; 2003;Pp 824,Pg No- 56, (Su, Su 13/12). [5]. E.P. Cherniack-Bugs as drugs, part two: worms, leeches, scorpions, snails, ticks, centipedes, and spiders; Altern Med Rev, 16 (2011), pp. 50-58; [6]. J. Tanyolac, T. Tanyolac;GenelZooloji, 7‘nci Basım -HatipogluYayinevi, Ankara (2008) [In Turkish] [7]. O.S. Gileva, K.Y. Mumcuoglu;Hirudotherapy- M. Grassberger, R.A. Sherman, O.S. Gileva, C.M.H. Kim, K.Y. Mumcuoglu (Eds.), Biotherapy-history, principles and practice: a practical guide to the diagnosis and treatment of disease using living organisms, Springer Science & Business Media, London (2013), pp. 31-76; [8]. C. Herlin, N. Bertheuil, F. Bekara, F. Boissiere, R. Sinna, B. Chaput-Leech therapy in flap salvage: systematic review and practical recommendationsAnnChirPlastEsthet, 62 (2016), pp. 1-13 [9]. A.M. Abdualkader, A.M. Ghawi, M. Alaama, M. Awang, A. Merzouk; Leech therapeutic applications;Indian J Pharm Sci, 75 (2013), pp. 127-137 [10]. AMAZING ATTAI VIDAL (LEECH THERAPY) IN SIDDHA -*Manikandan.B, Jenefa Rose Priya.T;Siddha Consultants;Corresponding Author: drmani2gh@gmail.com /Siddha Journals,cited on dated 2/3/2019 [11]. Javed Ahmed Khan and Shabbir Ahmed Khan, Irsal-e-Haq(Leech Therapy) in classical Literature of Unani System of Medicine-A Review-Journal of blood research, Vol 1,no A written informed consent should be obtained from the patient before hirudotherapy is initiated. The patients should be treated each day of leech therapy with anti-Aeromonas antibiotics. Leeches should be applied on the darker spots of the reattached body parts or flaps. Usually 1–10 leeches are used for each treatment, while at the beginning, the patient might need two or more treatments per day. Leech therapy is used until venous capillary return is established across the wound border by angiogenesis. Usually the treatment with leeches lasts for 2–6 days. Hematologic evaluations should be performed every 4 hrs and the patient has to receive blood transfusions when the hemoglobin level is lower than 8 g/dL. Signs of regional lymphadenitis, slight swelling, and pain of regional lymph nodes on the side of leech application and subfebrile temperature can occur. Contraindications related to hirudotherapy include arterial insufficiency, hemophilia, hemorrhagic diathesis, hematological