Selected Publications
2023
Masschelin PM, Saha PK, Ochsner SA, Cox AR, Kim KH, Felix JB, Sharp R, Li X, Tan L, Park JH, Wang L, Putluri V, Lorenzi PL, Nuotio-Antar A, Sun Z, Kaipparettu BA, Putluri N, Moore DD, Summers SA, McKenna NJ, Hartig SM. “Vitamin B2 Enables Regulation of Fasting Glucose Availability,” eLife, 12:e84077, 2023. PMID: 37417957
Heo MJ, Suh JH, Lee SH, Poulsen KL, An YA, Moorthy B, Hartig SM, Moore DD, Kim KH. “Aryl Hydrocarbon Receptor Maintains Hepatic Mitochondrial Homeostasis in Mice,” Molecular Metabolism, 72:101717, 2023. PMID: 37004989
2022
He Y, Brouwers B, Liu H, Liu H, Lawler K, de Oliveira EM, Lee DK, Yang Y, Cox AR, Keogh J, Henning E, Bounds R, Perdikari A, Ayinampudi V, Wang C, Yu M, Tu L, Zhang N, Yin N, Han J, Scarcelli NA, Yan Z, Conde KM, Potts C, Bean JC, Wang M, Hartig SM, Liao L, Xu J, Barroso I, Mokrosinski J, Elmquist JK, Xu Y, Farooqi IS. “Human Loss-of-Function Variants in the Serotonin 2C Receptor Associated with Obesity and Maladaptive Behavior,” Nature Medicine, 28:2537-2546, 2022. PMID: 36536256
Cox AR, Masschelin PM, Saha PK, Felix JB, Sharp R, Lian Z, Xia Y, Chernis N, Bader DA, Kim KH, Li X, Yoshino J, Li X, Sun Z, Wu H, Coarfa C, Moore DD, Klein S, Sun K, Hartig SM. “The Rheumatoid Arthritis Drug Auranofin Lowers Leptin Levels and Exerts Anti-Diabetic Effects in Obese Mice,” Cell Metabolism, 34:1932-1946, 2022. PMID: 36243005
Agarwal N, Ramirez-Bustamante CE, Wu H, Armamento-Villareal R, Lake JE, Balasubramanyam A, Hartig SM. “Heightened Levels of Plasma Growth Differentiation Factor 15 in Men Living with HIV,” Physiological Reports, 10:e15293, 2022. PMID: 35510313
Kim KH, Hartig SM. “Contributions of microRNAs to Insulin Sensitivity,” Endocrinology, 163:bqab250, 2022. PMID: 34882766
2021
Agarwal N, Iyer D, Saha P, Cox AR, Xia Y, Utay NS, Somasundaram A, Schubert U, Lake JE, Hartig SM, Balasubramanyam A. “HIV Vpr Couples Metabolic Inflexibility with White Adipose Tissue Thermogenesis,” Diabetes, 70:2014-2025, 2021. PMID: 34233931
Mao H, Li L, Fan Q, Angelini A, Saha PK, Wu H, Ballantyne C, Hartig SM, Xie L, Pi X. “Loss of Bone Morphogenetic Protein-Binding Endothelial Regulator Causes Insulin Resistance,” Nature Communications, 12:1927, 2021. PMID: 33772019
Cox AR, Chernis N, Kim KH, Masschelin PM, Saha PK, Briley SM, Sharp R, Li X, Felix JB, Sun Z, Moore DD, Pangas SA, Hartig SM. “Ube2i Deletion Causes Lipoatrophy in Mice,” Molecular Metabolism, 48:101221, 2021. PMID: 33771728
Felix JB, Cox AR, Hartig SM. “Acetyl-CoA and Metabolite Fluxes Regulate White Adipose Tissue Expansion,” Trends in Endocrinology and Metabolism, 32:320-332, 2021. PMID: 33712368
Antony A, Lian Z, Perrard XD, Perrard J, Liu H, Cox AR, Saha P, Hennighausen L, Hartig S, Ballantyne CM, Wu H. “Deficiency of STAT1 in CD11c+ Cells Reduces Adipose Tissue Inflammation and Improves Metabolic Dysfunctions in Mice Fed High-Fat-Diet,” Diabetes, 70:720-732, 2021. PMID: 33323395
2020
Cox AR, Chernis N, Bader DA, Saha PK, Masschelin PM, Felix JB, Sharp R, Lian Z, Putluri V, Rajapakshe K, Kim KH, Villareal DT, Armamento-Villareal R, Wu H, Coarfa C, Putluri N, Hartig SM, “STAT1 Dissociates Adipose Tissue Inflammation from Insulin Sensitivity in Obesity,” Diabetes, 69:2642-2654, 2020. PMID: 32994273
Dong B, Zhou Y, Wang W, Scott J, Kim KH, Sun Z, Guo Q, Lu Y, Gonzales NM, Wu H, Hartig S, York RB, Yang F, Moore DD. “Vitamin D Receptor Activation in Liver Macrophages Ameliorates Hepatic Inflammation, Steatosis, and Insulin Resistance in Mice,” Hepatology, 71:1559-1574, 2020. PMID: 31506976
Saha PK, Hamilton MP, Rajapakshe K, Putluri V, Felix JB, Masschelin P, Cox AR, Bajaj M, Putluri N, Coarfa C, Hartig SM. “miR-30a Targets Gene Networks that Promote Browning of Human and Mouse Adipocytes,” American Journal of Physiology-Endocrinology and Metabolism, 319:E667-E677, 2020. PMID: 32799658
Trevino LS, Dong J, Kaushal A, Katz TA, Jangid RK, Robertson MJ, Grimm S, Ambati CR, Putluri V, Cox AR, Kim KH, May TD, Gallo M, Moore DD, Hartig SM, Foulds CE, Putluri N, Coarfa C, Walker CL. “Epigenome-Environment Interactions Accelerate Epigenomic Aging and Drive Metabolic Dysfunction in the Liver,” Nature Communications, 11:2316, 2020. PMID: 32385268
Masschelin PM, Cox AR, Chernis N, Hartig SM. “The Impact of Oxidative Stress on Adipose Tissue Energy Balance,” Frontiers in Physiology, Jan 22; 10:1638, 2020. PMID: 32038305
Chernis N, Masschelin P, Cox AR, Hartig SM. “Bisphenol AF Promotes Inflammation in Human Adipocytes,” American Journal of Physiology-Cell Physiology, 318:C63-C72, 2020. PMID: 31596606
2019
Bader DA, Hartig SM, Putluri V, Foley C, Hamilton MP, Smith EA, Saha P, Panigrahi A, Walker C, Zong L, Martini-Stoica H, Chen R, Rajapakshe K, Coarfa C, Sreekumar A, Mitsiades N, Bankson JA, Ittmann MM, Putluri N, McGuire SE. “Mitochondrial Pyruvate Import is a Metabolic Vulnerability in Prostate Adenocarcinoma,” Nature Metabolism, 1:70-85, 2019. PMID: 31198906
Cox AR, Chernis N, Masschelin PM, Hartig SM. “Immune Cells Gate White Adipose Tissue Expansion,” Endocrinology, 160:1645-1658, 2019. PMID: 31107528
2018
Kim KH, Choi JM, Li F, Dong B, Wooton-Kee, CR, Arizpe A, Anakk, S, Jung SY, Hartig SM, Moore DD. “CAR Differentially Regulates Bile Acid Homeostasis in Mouse Models of Intrahepatic Cholestasis,” Hepatology Communications, 3:147-159, 2018. PMID: 30620001
Zhao N, Cao J, Xu L, Tang Q, Dobrolecki LE, Lyu X, Talukdar M, Lu Y, Wang X, Hu D, Shi Q, Xiang Y, Wang Y, Liu X, Bu W, Jiang Y, Li M, Gong Y, Sun Z, Ying H, Yuan B, Lin X, Feng XH, Hartig SM, Li F, Shen H, Chen Y, Han L, Zeng Q, Patterson J, Kaipparettu BA, Putluri N, Sicheri F, Rosen JM, Lewis MT, Chen X. “Pharmacological Targeting of MYC-Regulated IRE1a/XBP1 Pathway Suppresses MYC-Driven Breast Cancer,” The Journal of Clinical Investigation, 128:1283-1299, 2018. PMID: 29480818
Koh EH, Chernis N, Saha PK, Xiao L, Bader DA, Zhu B, Rajapakshe K, Hamilton MP, Liu X, Perera D, Chen X, York B, Trauner M, Coarfa C, Bajaj M, Moore DD, Deng T, McGuire SE, Hartig SM*. “miR-30a Remodels Subcutaneous Adipose Tissue Inflammation to Improve Insulin Sensitivity in Obesity,” Diabetes, 67:2541-2553, 2018. PMID: 30002134
2016
Koh EH, Chen Y, Bader DA, Hamilton MP, He B, York B, Kajimura S, McGuire SE, Hartig SM. “Mitochondrial Activity in Human White Adipocytes is Regulated by the Ubiquitin Carrier Protein 9/microRNA-30a Axis,” The Journal of Biological Chemistry, 291:24747-24755, 2016. PMID: 27758866
2015
Lin JZ, Martagon AJ, Cimini SL, Gonzalez DD, Tinkey DW, Biter A, Baxter JD, Webb P, Gustafsson JA, Hartig SM, Phillips KJ. “Pharmacological Activation of Thyroid Hormone Receptors Elicits a Functional Conversion of White to Brown Fat,” Cell Reports, 13:1528-1537, 2015. PMID: 26586443
Hartig SM, Bader DA, Abadie KV, Motamed M, Hamilton MP, Long W, York B, Mueller M, Wagner M, Trauner M, Chan L, Bajaj M, Moore DD, Mancini MA, McGuire SE. “Ubc9 Impairs Activation of the Brown Fat Energy Metabolism Program in Human White Adipocytes,” Molecular Endocrinology, 29:1320-1333, 2015. PMID: 26192107
Hartig SM, Hamilton MP, Bader DA, McGuire SE. “The miRNA Interactome in Metabolic Homeostasis,” Trends in Endocrinology and Metabolism, 26:733-745, 2015. PMID: 26492831
2013
Hamilton MP, Rajapakshe K, Hartig SM, Reva B, McLellan MD, Kandoth C, Ding L, Zack TI, Gunaratne PH, Wheeler DA, Coarfa C, McGuire SE, The Cancer Genome Atlas Network. “Identification of a Pan-Cancer Oncogenic microRNA Superfamily Anchored by a Central Core Seed Motif,” Nature Communications, 4:2730, 2013. PMID: 24220575
Hartig SM, Feng Q, Ochsner SA, Xiao R, McKenna NJ, McGuire SE, He B. “Androgen Receptor Agonism Promotes an Osteogenic Gene Program in Preadipocytes,” Biochemical and Biophysical Research Communications, 434:357-362, 2013. PMID: 23567971
Hartig SM. “Basic Image Analysis and Manipulation in ImageJ,” Current Protocols in Molecular Biology, Unit 14.15, 2013. PMID: 23547012
2012
Hartig SM, He B, Newberg JY, Sun H, Ochsner SA, Loose DS, Lanz RB, McKenna NJ, Buehrer BM, McGuire SE, Marcelli M, Mancini MA. “Feedforward Inhibition of Androgen Receptor During Human Adipocyte Differentiation,” Chemistry and Biology, 19:1126-1141, 2012. PMID: 22999881
2011
Hartig SM, Newberg JY, Bolt MJ, Szafran AT, Marcelli M, Mancini MA. “Automated Microscopy and Image Analysis for Androgen Receptor Function,” Methods in Molecular Biology, 776:313-331, 2011. PMID: 21796534
Hartig SM, He B, Long W, Buehrer BM, Mancini MA. “Homeostatic Levels of SRC-2 and SRC-3 Promote Early Human Adipogenesis,” The Journal of Cell Biology, 192:55-67, 2011. PMID: 21220509
2009
Hartig SM, Ishikura S, Hicklen RS, Feng Y, Blanchard EG, Voelker KA, Pichot CS, Grange RW, Raphael RM, Klip A, Corey SJ. “The F-BAR Protein CIP4 Promotes GLUT4 Endocytosis through Bidirectional Interactions with N-WASp and Dynamin-2,” Journal of Cell Science, 122:2283-2291, 2009. PMID: 19509061
2007
Hartig SM, Greene RR, Dikov MM, Prokop A, Davidson JM. “Multifunctional Polyelectrolyte Complexes,” Pharmaceutical Research, 12:2353-2369, 2007. PMID: 17932727
Hartig SM, Greene RR, Carlesso G, Higginbotham JN, Khan WN, Prokop A, Davidson JM. “Kinetic Analysis of Nanoparticulate Polyelectrolyte Complex Interactions with Endothelial Cells,” Biomaterials, 28:3843-3855, 2007. PMID: 17560645
Hartig SM, Carlesso, G, Davidson JM, Prokop A. “Development of Improved Nanoparticulate Polyelectrolyte Complex Physicochemistry by Non-Stoichiometric Mixing of Polyions with Similar Molecular Weights,” Biomacromolecules, 8:265-272, 2007. PMID: 17206816