Peer-Reviewed Journal Articles

† These authors contributed equally. * Corresponding author.

• Selected Publications

29. Clinical Soma and Neurite Density Imaging (SANDI): Translational microstructure mapping on standard 3T MRI

Lee H, Chan KS, Ma Y, Sung D, Han S, Lee DK, Krijnen EA, Eskandarian L, Bhatt A, Gerold J, Cho HJ, Huang SY*, Lee HH*

Magnetic Resonance in Medicine 2026.

28. Visualizing Cortical Laminar Architecture in Living Human Brain Using Next-Generation Ultra-High-Gradient Diffusion MRI

Lee H†, Ma Y†, Chan KS, Krijnen EA, Eskandarian L, Bhatt A, Gerold J, Mahmutovic M, Puonti O, Zeng X, Binder LJD, Fischl B, Keil B, Ramos-Llordén G, Klawiter EC, Lee HH*, Huang SY*

Communications Biology, 2026; 9(1):651. (IF: 5.8 | JCR Top 8.0%)

27. Age-related alterations in human cortical microstructure across the lifespan: Insights from high-gradient diffusion MRI

Lee H†, Lee HH†, Ma Y, Eskandarian L, Gaudet K, Tian Q, Krijnen EA, Russo AW, Salat DH, Klawiter EC, Huang SY*

Aging Cell 2024; 23(11):e14267. (IF: 7.1 | JCR Top 6.2% | Featured on the Cover)

26. Differential effect of iron and myelin on susceptibility MRI in the subdivisions of substantia nigra

Lee H†, Cho HJ†, Lee MJ, Kim TH, Roh J, and Lee JH*

Radiology 2021; 301(3):682-691. (IF: 29.1 | JCR Rank in Radiology: #1)

25. Specific visualization of neuromelanin iron complex and ferric iron in the human post-mortem substantia nigra using MR relaxometry at 7T

Lee H, Baek SY, Chun SY, Lee JH*, and Cho H*

NeuroImage 2018; 172:874-885. (IF: 5.8 | JCR Top 3.6%)

• Other First-Author Publications

24. Age-related alterations in hippocampal microstructure quantified using high-gradient diffusion MRI in an unfolded hippocampal space

Ma Y†, Lee H†, Chan KS, Eskandarian L, Gaudet K, Tian Q, Bhatt A, Gerold J, Russo AW, Salat DH, Huang SY, Lee HH*

Aging Cell 2025; e70274. (IF: 7.7 | JCR Top 10.4%)

23. Aberrant Vascular Architecture in the Hippocampus Correlates with Tau Burden in Mild Cognitive Impairment and Alzheimer’s Disease

Lee H, Fu F, Gaudet K, Bryant AG, Price JC, Bennett RE, Johnson KA, Hyman BT, Hedden T, Salat DH, Yen YF*, and Huang SY*

Journal of Cerebral Blood Flow & Metabolism 2024; 44(5):787-800.

22. Automated Volumetric Determination of High R2* Regions in Substantia Nigra (SN): A Feasibility Study of Quantifying SN Atrophy in PSP

Tessema A†, Lee H†, Gong Y, Cho H, Adem HM, Lyu I*, Lee JH*, and Cho HJ*

NMR in Biomedicine 2022; 35(11):e4795.

21. Iron accumulation in the oculomotor nerve of the progressive supranuclear palsy brain

Lee H, Lee MJ, Kim EJ, Huh GY, Lee JH*, and Cho HJ*

Scientific Reports 2021; 11(1):1-9.

20. MRI T2 and T2* relaxometry to visualize neuromelanin in the dorsal substantia nigra pars compacta

Lee H, Baek SY, Kim EJ, Huh GY, Lee JH*, and Cho HJ*

NeuroImage 2020; 211:116625. (IF: 6.6 | JCR Top 3.6%)

19. Pathologic correlation of paramagnetic white matter lesions in adult-onset leukoencephalopathy with axonal spheroids and pigmented glia

Kim M†, Lee H†, Cho HJ, Chun SY, Shin JH, Kim EJ, Ahn JW, Huh GY, Baek SY, and Lee JH*

Journal of Neuropathology & Experimental Neurology 2017; 76(11):924-928. (Featured on the Cover)

• Co-Authored Publications

18. Microstructural Characterization of Functional Network-Based Neurodegeneration in Multiple Sclerosis Using High-Gradient Diffusion MRI

Chiang FL, Krijnen EA, Sierkerka DA, Lee H, Lee HH, Bhatt A, Fox PT, Klawiter EC, Huang SY*

American Journal of Neuroradiology 2026.

17. Substantia Nigra Volumetry Improves Differentiation of Atypical Parkinsonian Syndromes

Candan HE†, Jo S†, Myratgeldiyev N, Tessema A, Lee H, Lee JH, Lee HY, Lee GY, Suh CH, Ryu J, Chung SJ, Park K, Lee EJ, Cho HJ*

Journal of Magnetic Resonance Imaging 2026.

16. Comparative Systematic Analysis of Gray Matter Biophysical Models on a Public Dataset

Mezzano S, Uhl Q, Pavan T, Nguyen-Du JND, Lee H, Huang SY, Jelescu I*

Magnetic Resonance in Medicine 2026.

15. Dependence of extra-cellular diffusion coefficient on the fractions of neurites and cell bodies in gray matter

Lee HH, Abdollahzadeh A, Lee H, Corondano-Leija R, Fieremans E, Novikov DS, Huang SY*

Magnetic Resonance in Medicine 2026.

14. Axon diameter mapping in the living human brain with ultra-high gradient diffusion MRI at 500 mT/m gradient strength

Ma Y†, Eskandarian L†, Chan KS, Lee H, Ramos-Llordén G, Bhatt A, Gerold J, Mahmutovic M, Keil B, Lee HH*, Huang SY*

Human Brain Mapping 2026 47(8):e70553.

13. Elevated Cerebral Oxygen Extraction Fraction in Parkinson’s Disease Correlates with Motor Impairment Severity

Candan HE, Lee DK, Lee H, Lee JH, Cho J*, Cho HJ*

Scientific Reports 2026.

12. Ultra-high gradient connectomics and microstructure MRI scanner for imaging of human brain circuits across scales

Ramos-Llordén G†, Lee HH†, Davids M, Dietz P, Krug A, Kirsch JE, Mahmutovic M, Scholz A, Ma Y, Lee H, Maffei C, Yendiki A, Bilgic B, Park DJ, Tian Q, Clifford B, Lo WC, Stocker S, Fischer J, Ruyters G, Roesler M, Potthast A, Benner T, Rummert E, Ramb R, Basser PJ, Witzel T, Wald LL, Rosen BR, Keil B, and Huang SY

Nature Biomedical Engineering 2026; 10(2):309-324. (IF: 26.3 | JCR Top 1.2%)

11. Automated Synthetic Contrast-Enhanced MRI Improves Choroid Plexus Segmentation in Parkinsonian Syndromes

Ambaye D†, Jo S†, Candan H, Tessema A, Myratgeldiyev N, Suh CH, Ryu JH, Chung SJ, Lee H, Lee JH, Lee EJ, and Cho H*

Radiology Advances 2025; umaf042.

10. Longitudinal changes in cortical cell body and neurite density in people with multiple sclerosis

Krijnen EA, Lee H, Ma Y, Lee HH, Schoonheim MM, Klawiter EC, Huang SY*

Neuroscience 2025.

9. In Vivo Cortical Microstructure Mapping Using High-Gradient Diffusion MRI Accounting for Intercompartmental Water Exchange Effects

Dong T, Lee HH, Zang H, Lee H, Tian Q, Wan L, Ming D, Fan Q*, Huang SY

NeuroImage 2025; 121258.

8. Interplay between MRI-based axon diameter and myelination estimates in macaque and human brain

Gong T*, Maffei C, Dann E, Lee HH, Lee H, Augustinack JC, Huang SY, Haber SN, Yendiki A

Imaging Neuroscience 2025; 3:imag_a_00576.

7. In vivo human neurite exchange imaging (NEXI) at 500 mT/m diffusion gradients

Chan KS, Ma Y, Lee H, Marques JP, Olesen J, Coelho S, Novikov DS, Jespersen S, Huang SY, Lee HH*

Imaging Neuroscience 2025; 3:imag_a_00544.

6. In vivo evidence for cell body loss in cortical lesions in people with multiple sclerosis

Krijnen EA, Lee H, Noteboom S, Chiang FL, Steenwijk MD, Schoonheim MM, Klawiter EC, Huang SY*

Annals of Clinical and Translational Neurology 2025; 12(1):4-16.

5. Intrinsic and extrinsic contributors to subregional thalamic volume loss in multiple sclerosis

Krijnen EA, Salim Karam E, Russo AW, Lee H, Chiang FL, Schoonheim MM, Huang SY*, and Klawiter EC*

Annals of Clinical and Translational Neurology 2024.

4. Detection of grey matter microstructural substrates of neurodegeneration in multiple sclerosis

Krijnen EA, Russo AW, Salim Karam E, Lee H, Chuang FL, Schoonheim MM, Huang SY*, and Klawiter EC*

Brain Communications 2023; fcad153.

3. Quantitative susceptibility mapping (QSM) and R1 measurement: as determination of myelin volume fraction in aging ex vivo rat corpus callosum

Cho H, Lee H, Gong Y, Kim YR, Cho J*, and Cho HJ*

NMR in Biomedicine 2022; 35(3):e4645.

2. Automation of pattern recognition analysis of dynamic contrast‐enhanced MRI data to characterize intratumoral vascular heterogeneity

Han S, Stoyanova R, Lee H, Carlin SD, Koutcher JA, Cho HJ, and Ackerstaff E*

Magnetic Resonance in Medicine 2018; 79(3):1736-1744.

1. The Neuromelanin-related T2* Contrast in Postmortem Human Substantia Nigra with 7T MRI

Lee JH, Baek SY, Song Y, Lim S, Lee H, Nguyen MP, Kim EJ, Huh GY, Chun SY*, and Cho HJ*

Scientific Reports 2016; 6:32647.

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