Research Aim

Our laboratory aims to elucidate the molecular mechanisms regulating human brain activity, with a primary focus on synaptic adhesion proteins. We are also dedicated to developing novel models of various brain disorders.

Research Background

Synapses are fundamental units where signal transmission occurs between neurons. Dysfunction of synaptic function has been implicated in a broad range of neurodevelopmental and neurodegenerative disorders. However, the exact pathogenic mechanisms remain to be fully understood.

Research Topics

• Investigating protein–protein interactions and brain function using genetically modified mouse models targeting synaptic adhesion proteins.

• Identifying new brain disease models by manipulating activity within complex neural circuits.

• Exploring the pathogenic mechanisms underlying disorders such as autism spectrum disorder and Parkinson’s disease.

Research Methods

• In vitro: Primary neuron culture, virus preparation (lentivirus, AAV), western blotting, protein purification, immunocytochemistry, immunohistochemistry, confocal and super-resolution microscopy, molecular cloning, RT-PCR, real-time PCR, and related techniques.

• In vivo: Stereotaxic injection, behavioral analysis, and additional experimental approaches.