Publications:
7: Michael X Wang,* Brandon E Mauch,* August F Williams, Tania Barazande-Pour, Filipe Araujo Hoffmann, Sophie H Harris, Cooper P Lathrop, Claire E Turkal, Bryan S Yung, Michelle H Paw, David A.G. Gervasio, Tiffany Tran, Anna E Stuhlfire, Theresa Guo, Gregory A Daniels, Soo J Park, J. Silvio Gutkind, Matthew J Hangauer. Antigenic cancer persister cells survive direct T cell attack. bioRxiv [Preprint]. 2025 Mar 17:2025.03.14.643359. doi: 10.1101/2025.03.14.643359. PMID: 40166148. *co-first authors
6: Masayoshi Higuchi,* August F. Williams,* Anna E. Stuhlfire,* Ariel H. Nguyen, David A. G. Gervasio, Claire E. Turkal, Suejean Chon, Matthew J. Hangauer. FSP1 and histone deacetylases suppress cancer persister cell ferroptosis. bioRxiv [Preprint]. 2025: Aug 25:2025.08.21.671520. doi: 10.1101/2025.08.21.671520. PMID: 40909720 *co-first authors
5: August F Williams, David A G Gervasio, Claire E Turkal, Anna E Stuhlfire, Michael X Wang, Brandon E Mauch, Rhea Plawat, Ariel H Nguyen, Michelle H Paw, Mehrshad Hairani, Cooper P Lathrop, Sophie H Harris, Jennifer L Page, Matthew J Hangauer. DFFB suppresses interferon to enable cancer persister cell regrowth. Nature Cell Biology 2025, in press.
4: Mariangela Russo, Mengnuo Chen, Elisa Mariella, Haoning Peng, Sumaiyah K. Rehman, Elena Sancho, Alberto Sogari, Tzen S. Toh, Nathalie Q. Balaban, Eduard Batlle, Rene Bernards, Mathew J. Garnett, Matthew Hangauer, Eleonora Leucci, Jean-Christophe Marine, Catherine A. O’Brien, Yaara Oren, E. Elizabeth Patton, Caroline Robert, Susan M. Rosenberg, Shensi Shen, Alberto Bardelli. Cancer drug-tolerant persister cells: from biological questions to clinical opportunities. Nature Reviews Cancer (2024). doi: 10.1038/s41568-024-00737-z. PMID 39223250
3: Matthew J Hangauer, Jorge Silvio Gutkind, Fleur M Ferguson. Pan-RAF:MEK Molecular Glues Take Center Stage. Cancer Discov. 2024 Jul 1;14(7):1143-1144. doi: 10.1158/2159-8290.CD-24-0539. PMID 38946324
2: Cancer Target Discovery and Development Network. An expanded universe of cancer targets. Cell. 2021 Mar 4;184(5):1142-1155. Doi: 10.1016/j.cell.2021.02.020. PMID: 33667368
1: Mues M, Karra L, Romero-Moya D, Wandler A, Hangauer MJ, Ksionda O, Thus Y, Lindenbergh M, Shannon K, McManus MT, Roose JP. High-Complexity shRNA Libraries and PI3 Kinase Inhibition in Cancer: High-Fidelity Synthetic Lethality Predictions. Cell Rep. 2019 Apr 9;27(2):631-647.e5. doi: 10.1016/j.celrep.2019.03.045. PMID: 30970263
Publications prior to UCSD:
20: Hangauer MJ, Viswanathan VS, Ryan MJ, Bole D, Eaton JK, Matov A, Galeas J, Dhruv HD, Berens ME, Schreiber SL, McCormick F&, McManus MT&. Drug-tolerant persister cancer cells are vulnerable to GPX4 inhibition. Nature. 2017 Nov 9;551(7679):247-250. doi: 10.1038/nature24297. Epub 2017 Nov 1. PMID: 29088702, PMCID: PMC5933935, &co-corresponding authors.
Press coverage: “The Ferrous Awakens”, Cell, 11/30/2017. “Fighting Resilient Cancers With Iron” Trends in Cell Biology, 12/6/2017. “Diverse Drug-Resistant Cancer Cells Share a Hidden Weakness”, UCSF News, 11/3/2017. “GPX4 Inhibition Selectively Targets Drug-Tolerant Persister Cells”, Cancer Discovery, 11/10/2017.
19: Cancer Target Discovery and Development Network#. Transforming Big Data into cancer-relevant insight: An initial, multi-tier approach to assess reproducibility and relevance. Mol Cancer Res. 2016 Aug;14(8):675-82. doi: 10.1158/1541-7786.MCR-16-0090. Epub 2016 Jul 11. PMID: 27401613. PMCID: PMC4987219
#full author list: http://mcr.aacrjournals.org/content/early/2016/07/09/1541-7786.MCR-16-0090
18: Tetsu O, Hangauer MJ, Phuchareon J, Eisele DW, McCormick F. Drug resistance to EGFR inhibitors in lung cancer. Chemotherapy. 2016 Feb 25;61(5):223-235. Review. PMID: 2691073.
17: Tetsu O, Phuchareon J, Eisele DW, Hangauer MJ, McCormick F. AKT inactivation causes persistent drug tolerance to EGFR inhibitors. Pharmacol Res. 2015 Dec; 102:132-7. doi: 10.1016/j.phrs.2015.09.022. Epub 2015 Oct 22. Review. PMID: 26453958.
16: Roadmap Epigenomics Consortium#, Integrative analysis of 111 reference human epigenomes. Nature. 2015 Feb 19;518(7539):317-30. doi: 10.1038/nature14248. PMID: 25693563; PMCID: PMC4530010.
#full author list: http://www.nature.com/nature/journal/v518/n7539/full/nature14248.html#author-information
15: Gascard P, Bilenky M, Sigaroudinia M, Zhao J, Li L, Carles A, Delaney A, Tam A, Kamoh B, Cho S, Griffith M, Chu A, Robertson G, Cheung D, Li I, Heravi-Moussavi A, Moksa M, Mingay M, Hussainkhel A, Davis B, Nagarajan RP, Hong C, Echipare L, O'Geen H, Hangauer MJ, Cheng JB, Neel D, Hu D, McManus MT, Moore R, Mungall A, Ma Y, Plettner P, Ziv E, Wang T, Farnham PJ, Jones SJ, Marra MA, Tlsty TD, Costello JF, Hirst M. Epigenetic and transcriptional determinants of the human breast. Nat Commun. 2015 Feb 18; 6:6351. doi: 10.1038/ncomms7351. PMID: 25690954; PMCID: PMC4346612.
14: Hangauer MJ, Carpenter S, McManus MT. Discovering the complexity of the metazoan transcriptome. Genome Biol. 2014 Apr 29;15(4):112. doi: 10.1186/gb4172. PMID: 25001157; PMCID: PMC4054782.
13: Palaniappan KK, Hangauer MJ, Smith TJ, Smart BP, Pitcher AA, Cheng EH, Bertozzi CR, Boyce M. A chemical glycoproteomics platform reveals O-GlcNAcylation of mitochondrial voltage-dependent anion channel 2. Cell Rep. 2013 Oct 31;5(2):546-52. doi: 10.1016/j.celrep.2013.08.048. PMID: 24120863; PMCID: PMC3869705.
12: Hangauer MJ*, Vaughn IW*, McManus MT. Pervasive transcription of the human genome produces thousands of previously unidentified long intergenic noncoding RNAs. PLoS Genet. 2013 Jun;9(6):e1003569. doi: 10.1371/journal.pgen.1003569. PMID: 23818866; PMCID: PMC3688513. *co-first authors.
Press coverage: “Finding function in mystery transcripts” Nature 2016, 529, 423. “Listening to the Genome: Music or Noise?”, National Geographic website, 6/21/2013. “Corroboration for ENCODE?”, Science Translational Medicine “In The Pipeline”, 7/1/2013. “DNA Found Outside Genes Plays Largely Unknown, Potentially Vital Roles: UCSF Study Identifies Thousands of Previously Unknown RNA Molecules”, UCSF News, 6/27/2013. Thomson Reuters Web of Science “Highly Cited Paper” (top 1%).
11: Shieh P*, Hangauer MJ*, Bertozzi CR. Fluorogenic azidofluoresceins for biological imaging. J Am Chem Soc. 2012 Oct 24;134(42):17428-31. doi: 10.1021/ja308203h. PMID: 23025473; PMCID: PMC3596100. *co-first authors.
10: Ku GM, Kim H, Vaughn IW, Hangauer MJ, Myung Oh C, German MS, McManus MT. Research resource: RNA-Seq reveals unique features of the pancreatic β-cell transcriptome. Mol Endocrinol. 2012 Oct;26(10):1783-92. PMID: 22915829; PMCID: PMC3458219.
9: Boyce M, Carrico IS, Ganguli AS, Yu SH, Hangauer MJ, Hubbard SC, Kohler JJ, Bertozzi CR. Metabolic cross-talk allows labeling of O-linked beta-N-acetylglucosamine-modified proteins via the N acetylgalactosamine salvage pathway. Proc Natl Acad Sci U S A. 2011 Feb 22;108(8):3141-6. doi: 10.1073/pnas.1010045108. PMID: 21300897; PMCID: PMC3044403.
8: Beatty KE, Fisk JD, Smart BP, Lu YY, Szychowski J, Hangauer MJ, Baskin JM, Bertozzi CR, Tirrell DA. Live-cell imaging of cellular proteins by a strain-promoted azide-alkyne cycloaddition. Chembiochem. 2010 Oct 18;11(15):2092-5. doi: 10.1002/cbic.201000419. PMID: 20836119; PMCID: PMC3069858.
7: Barb AW, Leavy TM, Robins LI, Guan Z, Six DA, Zhou P, Hangauer MJ, Bertozzi CR, Raetz CR. Uridine-based inhibitors as new leads for antibiotics targeting Escherichia coli LpxC. Biochemistry. 2009 Apr 14;48(14):3068-77. doi: 10.1021/bi900167q. Erratum in: Biochemistry. 2009 Aug 18;48(32):7776. PMID: 19256534; PMCID: PMC2709817.
6: Hangauer MJ, Bertozzi CR. A FRET-based fluorogenic phosphine for live-cell imaging with the Staudinger ligation. Angew Chem Int Ed Engl. 2008;47(13):2394-7. doi: 10.1002/anie.200704847. PMID: 18306205; PMCID: PMC2446402.
Press coverage: "Cell Imaging: Sweet Glow of Success" Nature 2008, 452, 390. Angewandte Chemie Cover Article.
5: Kostiuk MA, Corvi MM, Keller BO, Plummer G, Prescher JA, Hangauer MJ, Bertozzi CR, Rajaiah G, Falck JR, Berthiaume LG. Identification of palmitoylated mitochondrial proteins using a bio-orthogonal azido-palmitate analogue. FASEB J. 2008 Mar;22(3):721-32. PMID: 17971398; PMCID: PMC2860959.
4: Chang PV, Prescher JA, Hangauer MJ, Bertozzi CR. Imaging cell surface glycans with bioorthogonal chemical reporters. J Am Chem Soc. 2007 Jul 11;129(27):8400-1. PMID: 17579403; PMCID: PMC2535820.
3: Laughlin ST, Agard NJ, Baskin JM, Carrico IS, Chang PV, Ganguli AS, Hangauer MJ, Lo A, Prescher JA, Bertozzi CR. Metabolic labeling of glycans with azido sugars for visualization and glycoproteomics. Methods Enzymol. 2006; 415:230-50. PMID: 17116478.
2: Norris JL, Hangauer MJ, Porter NA, Caprioli RM. Nonacid cleavable detergents applied to MALDI mass spectrometry profiling of whole cells. J Mass Spectrom. 2005 Oct;40(10):1319-26. PMID: 16220468.
1: Milkiewicz KL, Marsilje TH, Woodworth RP Jr, Bifulco N Jr, Hangauer MJ, Hangauer DG. The design, synthesis and activity of non-ATP competitive inhibitors of pp60(c-src) tyrosine kinase. Part 2: hydroxyindole derivatives. Bioorg Med Chem Lett. 2000 Mar 6;10(5):483-6. PMID: 10743953.
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