Organelle Homeostasis &
Aging-Related Disease Lab
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세포소기관 항상성 및 노화연관질환 연구실 (Organelle Homeostasis & Aging Disease Lab)
Research interest
Our laboratory investigates how mitochondrial homeostasis governs cellular fate decisions in aging-related diseases. We focus on the molecular mechanisms that integrate mitochondrial protein quality control, metabolism, and calcium signaling to maintain cellular integrity under stress.
Mitochondria are central hubs for energy production, metabolite signaling, and apoptotic regulation. Dysregulation of these processes is a key driver of neurodegeneration, including Parkinson’s disease, as well as metabolic disorders such as diabetes. Our research aims to uncover how mitochondrial stress is sensed and resolved through coordinated pathways involving mitophagy, chaperone systems, and metabolite-mediated signaling.
We are particularly interested in:
Mechanistic regulation of mitophagy and mitochondrial quality control (e.g., PINK1–Parkin pathway)
Metabolic rewiring and signaling metabolites (such as fumarate) in disease contexts
ER–mitochondria crosstalk and calcium signaling in cell survival and degeneration
The role of mitochondrial dysfunction in neurodegenerative and metabolic diseases, including Parkinson’s disease and diabetic neuropathy
By integrating molecular biology, genetics, and in vivo disease models, we aim to define fundamental principles of mitochondrial regulation and translate these findings into therapeutic strategies for aging-associated diseases.
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