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RNAs: regulators of bacterial virulence
The Laboratory of Molecular Microbiology investigates how RNA-based pathways regulate gene and protein expression in pathogenic bacteria. Our research focuses on regulatory RNAs, including untranslated regions (UTRs), cis-acting antisense RNAs, and trans-acting small non-coding RNAs, which respond to environmental cues such as temperature, pH, and metabolite levels. We aim to understand how these RNAs and associated proteins, such as RNases, coordinate mRNA stability and translation, ultimately influencing bacterial virulence and adaptation to host environments.
Why is an RNA stability control study important for microbial pathogens?
Regulation of RNA stability is directly related to the stability of virulence factors.
Regulation of RNA stability is directly related to the stability of virulence factors.
The regulation of RNA stability is the interaction of various factors involved.
The regulation of RNA stability is the interaction of various factors involved.
Recently, studies on the regulation of RNA stability have gained prominence.
Recently, studies on the regulation of RNA stability have gained prominence.
Antimicrobial peptides (AMPs)
The Laboratory of Molecular Microbiology focuses on developing novel therapeutic strategies to combat antimicrobial resistance in human and animal pathogens. We particularly investigate antimicrobial peptides (AMPs) as next-generation therapeutics, exploring their diverse structural features, mechanisms of action, and molecular targets. Our studies aim to elucidate the resistance and cross-resistance mechanisms and design optimized AMP structures with enhanced efficacy and stability. Through a multidisciplinary approach combining structural biology, microbiology, and bioinformatics, we aim to contribute to the development of innovative antimicrobial therapies with translational potential in clinical and veterinary medicine.
Direction of the research
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