Research

I am working at the interface between health and mathematics, using mathematical modelling and statistical methods to explain and better understand biological systems and processes, in particular in the case of hematopoiesis and blood cancers.

Publications

• Donada, A., Hermange, G., Tocci, T., Midoun, A., Prevedello, G., Hadj Abed, L., ... & Perie, L. (2025). Clonal memory of cell division in humans diverges between healthy haematopoiesis and acute myeloid leukaemia. bioRxiv, 2025-06.

• Hermange, G., Cournède, P.-H., Plo, I., Modèles mathématiques pour mieux comprendre la cellule souche hématopoïétique. In : Alessi MC, Leporrier M, Vainchenker W. Traité d’hématologie, Ed. 2025 Paris, TdM Éditions

• Hermange, G., Vainchenker, W., Plo, I., and Cournède, P.-H. (2024). Mathematical modelling, selection and hierarchical inference to determine the minimal dose in IFNα therapy against Myeloproliferative Neoplasms. Mathematical Medicine and Biology. Link (or on arXiv:2112.10688).

• Hermange, G., Cournède, P. H., & Plo, I. (2023). Optimizing IFN alpha therapy against Myeloproliferative Neoplasms. Journal of Pharmacology and Experimental Therapeutics. Link.

• Hermange, G., Rakotonirainy, A., Bentriou, M, ..., & Cournède, P.-H. (2022). Inferring the initiation and development of myeloproliferative neoplasms. PNAS. Link (or here on HAL, and here a vulgarized summary).

• Hermange, G., Cournède, P.-H., and Plo, I. (2022). Modélisation mathématique de l'hématopoïèse et des hémopathies : développement, dynamique et traitement. Hématologie. Link.  

• Mosca, M.*, Hermange, G.*, Tisserand, A.*, Noble, R.*, Marzac, C., Marty, C., ... & Plo, I. (2021). Inferring the dynamics of mutated hematopoietic stem and progenitor cells induced by IFNα in myeloproliferative neoplasms. Blood. Link (or here on HAL, and here a vulgarized summary). 

(* denotes equal contributions)

Scientific presentations:

Conferences

• Congrès de la SFH - 27 march 2024
  Intérêt de la modélisation mathématique dans les Syndromes Myéloprolifératifs

• FIM Scientific Day (France Intergroupe des syndromes Myéloprolifératifs) - Paris - 20 november 2023
  Modèles mathématiques d’optimisation de la thérapie par Interféron  

• CHO ( Club Hématopoïèse et Oncogenèse) annual congress at Presqu'Ile de Giens - 11-14 october 2023
  Sister cells in Harmony: Experimental and Mathematical Evidence of Homogeneity in Human HSPC 

• European Control Conference (ECC23) - Bucharest (Romania) - 13-16 june 2023

Tutorial Session: Early screening for blood cancers

• Journée AppliBUGS at CentraleSupélec- 15 december 2022

Inférence Bayésienne sur des modèles de Néoplasmes Myéloprolifératifs : de l'apparition au traitement

• Rencontres MAMOVI at Ecole Polytechnique- 13-15 december 2021

Modélisation et inférence Bayésienne pour étudier l'apparition et le traitement des Néoplasmes Myéloprolifératifs

Posters

• Congrès de la SFH - 29-31 march 2023

Poster Session - Modélisation mathématique du développement des Néoplasmes Myéloprolifératifs : application au dépistage précoce et à l’optimisation de traitement 

• ESH 9th Translational Research Conference: Myeloproliferative Neoplasms - 12-15 may 2022

Poster Session - Inferring the initiation and development of Myeloproliferative Neoplasms

• IBOMAN at Institut Curie (Paris)- 25-27 october 2021

Poster Session - Mathematical modeling of stem cell dynamics in response to IFNα therapy in MPN

• CHO ( Club Hématopoïèse et Oncogenèse) annual congress at Presqu'Ile de Giens - 29/09- 02/10/2021

Poster Session - Inferring the dynamics of mutated hematopoietic stem and progenitor cells induced by IFNα in MPN

Poster Award by the SFG (Société Française de Génétique)

• 2nd International Symposium on Mathematical and Computational Oncology (ISMCO'20) - 8-10 october 2020

Poster Session - Model of hematopoiesis dynamics under IFN alpha therapy in Myeloproliferative Neoplasms

Seminars & Talks

• SaMMBA Seminar at Institut Pasteur - 10 September 2025
  Mathematical Modelling and Bayesian Inference for Studying MPN Blood Cancers

• Paris Health AI Workshop at Owkin HQ - 3rd July 2025
  Knowledge- and Data-Driven Methods  in Blood Cancers

• MICS/CVN Summer Fest at CentraleSupélec - 19 June 2025
  Presentation of a pedagogical project: an epidemiological challenge

• Biomathematics seminar  at CentraleSupélec - 8 october 2024

Hierarchical Approximate Bayesian Computation and a new model of MPN development

• Seminar at Rotskilde University (Denmark) - 23 August 2024
  Mathematical modeling of Myeloproliferative Neoplasms

• Computational Biology Meetings  at Gustave Roussy Institute - 26 april 2024
  Mathematical Modeling and Bayesian Inference methods in the study of development and treatment of MPNs

• Research Unit Seminar at Gustave Roussy Institute - 30 november 2023

Sister cells in harmony : organising principles of human hematopoietic progenitors dynamics - with A. Donada (Curie Institute)

• Biomathematics seminar  at CentraleSupélec - 24 october 2023

Sister cells in Harmony

• Team seminar at Institut Curie - 4 october 2023
  Sister cells in Harmony

• Seminar at Rotskilde University (Denmark) - 14 August 2023
  Mathematical modeling of Myeloproliferative Neoplasms: from their development to their treatment with Interferon alpha

• Research Unit Seminar at Gustave Roussy Institute (Unit UMR 1287) - 26 january 2023

Mathematical methods for inferring the development of Myeloproliferative Neoplasms

• Team seminar at Institut Curie - 25 january 2023

Mathematical modelling of Myeloproliferative Neoplasms: from their development to their treatment.

• Ateliers du FIM - 24 january 2023

Etude du mécanisme d’action de l’IFN alpha (projet OPTIMYN) 

• Biomathematics seminar  at CentraleSupélec - 10 january 2023

Inferring the initiation and development of Myeloproliferative Neoplasms

• Team seminar at Institut Curie - 14 september 2022

Hematopoietic stem and progenitor cell dynamics

• Team seminar at Institut Curie - 4 may 2022

How Hematopoietic Stem and Progenitor cells proliferate?

• Team seminar  at Gustave Roussy Institute - 28 june 2021

Inferring the initiation and development of Myeloproliferative Neoplasms

• Biomathematics seminar  at CentraleSupélec - 1st june 2021

Apparition and expansion of malignant clones in Myeloproliferative Neoplasms

• Team seminar  at Gustave Roussy Institute - 19 April 2021

CyTOF data processing : Issues & perspectives of solutions

• Research Unit Seminar at Gustave Roussy Institute (Unit UMR 1287) - 17 march 2021

Mathematical Modeling of the response of MPN patients to IFNα

• Biomathematics seminar  at CentraleSupélec - 25 february 2020

Cellular proliferation and mathematical tools

Others:

• Member of the organisation committee of a research school in "Mathematical Fundations for Spatial Omics in Oncology" (2026)

• Member of the scientific committee of the AI & Oncology conference by IHU Prism (2025)

• First PhD price "Impact Science" - Fondation CentraleSupélec - 2023

• Science popularization:

  • Café science at CentraleSupélec - 8 june, 2023
    Comprendre les cancers du sang à l'aide de modèles mathématiques,  du dépistage au traitement  

• Organisation of "Young Researcher Seminars" at MICS lab - 2021