Research
I am working at the interface between health and mathematics, using mathematical modelling and statistical methods to explain and better understand biological systems and processes, in particular in the case of hematopoiesis and blood cancers.
Research Topics:
Mathematics:
Bayesian analysis
- Hierarchical models
- Computational statistics (MCMC, ABC)
- Model selection
Mathematical models
- Deterministic models
- Stochastics processes (PDMP, CTMC, Branching Processes, Multi-agents systems)
Single-cell analysis
Biology & Health:
Hematopoiesis (normal and pathological)
Myeloproliferative Neoplasms (MPN)
- Predicting and optimizing the response of MPN patients to IFN alpha
- Modelling the disease initiation and its expansion
Hematopoietic Stem Cells (HSCs)
Phylogenetics
Publications
Hermange, G., Vainchenker, W., Plo, I., and Cournède, P.-H. (2024). Mathematical modelling, selection and hierarchical inference to determine the minimal dose in IFNα therapy against Myeloproliferative Neoplasms. Mathematical Medicine and Biology. Link (or on arXiv:2112.10688).
Hermange, G., Cournède, P. H., & Plo, I. (2023). Optimizing IFN alpha therapy against Myeloproliferative Neoplasms. Journal of Pharmacology and Experimental Therapeutics. Link.
Hermange, G., Rakotonirainy, A., Bentriou, M, ..., & Cournède, P.-H. (2022). Inferring the initiation and development of myeloproliferative neoplasms. PNAS. Link (or here on HAL, and here a vulgarized summary).
Hermange, G., Cournède, P.-H., and Plo, I. (2022). Modélisation mathématique de l'hématopoïèse et des hémopathies : développement, dynamique et traitement. Hématologie. Link.
Mosca, M.*, Hermange, G.*, Tisserand, A.*, Noble, R.*, Marzac, C., Marty, C., ... & Plo, I. (2021). Inferring the dynamics of mutated hematopoietic stem and progenitor cells induced by IFNα in myeloproliferative neoplasms. Blood. Link (or here on HAL, and here a vulgarized summary).
(* denotes equal contributions)
Scientific presentations:
Conferences
Congrès de la SFH - 27 march 2024
Intérêt de la modélisation mathématique dans les Syndromes MyéloprolifératifsFIM Scientific Day (France Intergroupe des syndromes Myéloprolifératifs) - Paris - 20 november 2023
Modèles mathématiques d’optimisation de la thérapie par InterféronCHO ( Club Hématopoïèse et Oncogenèse) annual congress at Presqu'Ile de Giens - 11-14 october 2023
Sister cells in Harmony: Experimental and Mathematical Evidence of Homogeneity in Human HSPCEuropean Control Conference (ECC23) - Bucharest (Romania) - 13-16 june 2023
Tutorial Session: Early screening for blood cancers
Journée AppliBUGS at CentraleSupélec- 15 december 2022
Inférence Bayésienne sur des modèles de Néoplasmes Myéloprolifératifs : de l'apparition au traitement
Rencontres MAMOVI at Ecole Polytechnique- 13-15 december 2021
Modélisation et inférence Bayésienne pour étudier l'apparition et le traitement des Néoplasmes Myéloprolifératifs
Posters
Congrès de la SFH - 29-31 march 2023
Poster Session - Modélisation mathématique du développement des Néoplasmes Myéloprolifératifs : application au dépistage précoce et à l’optimisation de traitement
ESH 9th Translational Research Conference: Myeloproliferative Neoplasms - 12-15 may 2022
Poster Session - Inferring the initiation and development of Myeloproliferative Neoplasms
IBOMAN at Institut Curie (Paris)- 25-27 october 2021
Poster Session - Mathematical modeling of stem cell dynamics in response to IFNα therapy in MPN
CHO ( Club Hématopoïèse et Oncogenèse) annual congress at Presqu'Ile de Giens - 29/09- 02/10/2021
Poster Session - Inferring the dynamics of mutated hematopoietic stem and progenitor cells induced by IFNα in MPN
Poster Award by the SFG (Société Française de Génétique)
2nd International Symposium on Mathematical and Computational Oncology (ISMCO'20) - 8-10 october 2020
Poster Session - Model of hematopoiesis dynamics under IFN alpha therapy in Myeloproliferative Neoplasms
Seminars & Talks
Computational Biology Meetings at Gustave Roussy Institute - 26 april 2024
Mathematical Modeling and Bayesian Inference methods in the study of development and treatment of MPNsResearch Unit Seminar at Gustave Roussy Institute - 30 november 2023
Sister cells in harmony : organising principles of human hematopoietic progenitors dynamics - with A. Donada (Curie Institute)
Biomathematics seminar at CentraleSupélec - 24 october 2023
Sister cells in Harmony
Team seminar at Institut Curie - 4 october 2023
Sister cells in HarmonySeminar at Rotskilde University (Denmark) - 14 August 2023
Mathematical modeling of Myeloproliferative Neoplasms: from their development to their treatment with Interferon alphaResearch Unit Seminar at Gustave Roussy Institute (Unit UMR 1287) - 26 january 2023
Mathematical methods for inferring the development of Myeloproliferative Neoplasms
Team seminar at Institut Curie - 25 january 2023
Mathematical modelling of Myeloproliferative Neoplasms: from their development to their treatment.
Ateliers du FIM - 24 january 2023
Etude du mécanisme d’action de l’IFN alpha (projet OPTIMYN)
Biomathematics seminar at CentraleSupélec - 10 january 2023
Inferring the initiation and development of Myeloproliferative Neoplasms
Team seminar at Institut Curie - 14 september 2022
Hematopoietic stem and progenitor cell dynamics
Team seminar at Institut Curie - 4 may 2022
How Hematopoietic Stem and Progenitor cells proliferate?
Team seminar at Gustave Roussy Institute - 28 june 2021
Inferring the initiation and development of Myeloproliferative Neoplasms
Biomathematics seminar at CentraleSupélec - 1st june 2021
Apparition and expansion of malignant clones in Myeloproliferative Neoplasms
Team seminar at Gustave Roussy Institute - 19 April 2021
CyTOF data processing : Issues & perspectives of solutions
Research Unit Seminar at Gustave Roussy Institute (Unit UMR 1287) - 17 march 2021
Mathematical Modeling of the response of MPN patients to IFNα
Biomathematics seminar at CentraleSupélec - 25 february 2020
Cellular proliferation and mathematical tools
Others:
First PhD price "Impact Science" - Fondation CentraleSupélec - 2023
Science popularization:
Café science at CentraleSupélec - 8 june, 2023
Comprendre les cancers du sang à l'aide de modèles mathématiques, du dépistage au traitement
Organisation of "Young Researcher Seminars" at MICS lab