Books

This monograph brings forth biomechanical research methods and outcomes on human tissue experiments such as those of the brain and the heart under a single umbrella. Different mechanical characterization techniques employed in human tissue property estimation are presented in detail. The contents also focus on a hyperelastic constitutive model (e.g., Mooney-Rivlin, Ogden) for both isotropic and anisotropic tissue characterization. It also discusses energy dissipation in soft tissues and associated viscoelasticity. Human tissues, including skin, muscles, connective tissues, and tissues in all functional organs are listed and their mechanical properties are presented in detail. These tissue properties are indispensable for computational modeling of biological systems, validation of biomechanical tissue testing, medical simulation through development of artificial phantoms and surrogates, and testing of medical devices and interventions. This book will serve as a key reference for research in tissue engineering & biomedical engineering, medical simulation, biomechanics, finite element modeling of biological systems, biomaterials, biotechnology, implant and medical device development, and healthcare wearables. 

The book provides an overview of prospective material simulants for hard tissues, such as knee joints, hip joint, and bones, and soft tissues, such as skin, muscles, and functional organs. These materials can repair, replace the functionality, or mimic the mechanical, structural, and biological properties of the parent tissue. This book discusses hard and soft human tissue simulating biomaterials under a single umbrella, covering a broad area of design and development of biomaterials, implants, and multi-functional materials along with their characterization. The progress in emerging biomaterials has increased manifold in the recent decades with the unprecedented focus on healthcare technologies. This book is dedicated to ground-breaking research in biomaterials and highlights the current trends and future roadmap of different materials for simulation of hard and soft tissues. Authored by prominent researchers around the globe, the chapters of this book emphasize recent advances in biomedical material simulation. This book brings together novel contributions to different aspects of hard and soft human tissue-based biomaterials, including recent advances and emerging developments in designing and developing simulants for tissue replacement alternatives. This book is anticipated to serve as a key reference textbook for research in tissue engineering & biomedical engineering, biomaterials, biomechanics, and implant & medical device development with contributed chapters solicited in the areas of  soft materials, such as elastomers, hydrogels, etc., for various applications; auxetic metamaterials; additive manufacturing of bio-implants; artificial tissues and organs; development of biomimetic materials; medical implants and biomedical device design; bioinspired and bio-tribological materials; advances in materials science for biomaterial applications; biomechanical characterization of hard and soft human tissues; bioprinting and nano-biomaterials.

Soft tissue simulants, essential for automotive and ballistic testing, medical, and surgical training, have traditionally relied on cadavers and animal tissues. However, their biomechanical properties change with time due to dehydration after death and the biomechanics of the animal models cannot be translated and compared with the human tissues. This book compiles various synthetic tissues used in these applications, addressing their characterization and industry-wide applications. While older simulants lack biofidelity, recent advancements in biofidelic soft tissue simulants offer promising alternatives, yet technology transfer remains limited. This book fills the gap by exploring each simulant's characteristics and current trends, facilitating their adoption in clinical and academic settings. These synthetic tissues have the potential to replace live tissues in surgical training, streamlining biosafety approvals. They also benefit academic researchers by reducing costs and time in biomechanical testing. Anticipated to be the first of its kind, this comprehensive reference book will showcase recent advancements in soft tissue simulant development, serving as a cornerstone text in tissue engineering & biomedical engineering, medical simulation, biomechanics, and related fields.